Cronshaw, Janet - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2016 – present: Teaching Assistant. Department of Molecular Biology and Biotechnology, University of Sheffield. 2014 – 2016: Daphne Jackson Fellow. Department of Molecular Biology and Biotechnology, University of Sheffield. 2004 – 2008: Post-doctoral research scientist. Nuclear Transport Laboratory and Mammalian Genetics Laboratory, CRUK London Research Institute. 2000 – 2004: Post-doctoral research scientist. Bloomberg School of Public Health, Johns Hopkins University, Baltimore, USA. 1996 – 1999: PhD student. Paterson Institute for Cancer Research, Manchester. 1993 – 1996: BA in Natural Sciences, University of Cambridge. About I completed my PhD at the Paterson Institute for Cancer Research in Manchester where my interests centred on nucleocytoplasmic transport and the Nuclear Pore Complex (NPC). Following this I moved to Johns Hopkins University in Baltimore, USA, where I expanded these interests by defining the protein composition of NPCs for the first time. Upon moving back to the UK to work at CRUK's London Research Institute, I studied the RNA-binding properties of proteins involved in epigenetic control of gene expression and the regulation of DNA damage signalling. Following a career break, I secured a Daphne Jackson Career Re-entry Fellowship, during which I investigated a novel pathway of mRNA export that bypasses the NPC.

研究领域

Teaching in practicals MBB165 and MBB265 and MBB110 Maths for Biomolecular Sciences

近期论文

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Kanu N, Zhang T, Burrell RA, Chakraborty A, Cronshaw J, Da Costa C, Grönroos E, Pemberton H, Anderton E, Gonzalez L, Sabbioneda S, Ulrich H, Swanton C, Behrens A (2015). RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress. Oncogene doi: 10.1038/onc.2015.427 Zhang T, Cronshaw JM, Behrens A (2014). UBR5-mediated ubiquitination of ATMIN is required for IR-induced ATM signalling and function. Proc Natl Acad Sci U S A 111 12091-12096 Cronshaw JM, Matunis MJ (2004). The nuclear pore complex: disease associations and functional correlations. Trends Endocrinol Metab. 15 34-39 Cronshaw JM, Matunis MJ (2003). The nuclear pore complex protein ALADIN is mislocalized in triple A syndrome. Proc Natl Acad Sci USA 100 5823-5827 Wells L, Vosseller K, Cole RN, Cronshaw JM, Matunis MJ, Hart GW (2002). Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications. Mol Cell Proteomics 1 791-804 Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ (2002). Proteomic Analysis of the Mammalian Nuclear Pore Complex. J Cell Biol 158 915-927 Bagley S, Goldberg MW, Cronshaw JM, Rutherford S, Allen TD (2000). The nuclear pore complex. J Cell Sci 113 3885-3886 Kiseleva E, Goldberg MW, Cronshaw J, Allen TD (2000). The nuclear pore complex: structure, function and dynamics. Crit Rev Eukaryot Gene Expr 10 101-112 Allen TD, Cronshaw JM, Bagley S, Kiseleva E, Goldberg MW (2000). The nuclear pore complex: mediator of translocation between nucleus and cytoplasm. J Cell Sci 113 1651 -1659 Goldberg MW, Cronshaw JM, Kiseleva E, Allen TD (1999). Nuclear pore complex dynamics and transport in higher eukaryotes. Protoplasma 209 144-156