Bullough, Per - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2001 - present: Professor, Dept. of Molecular Biology and Biotechnology, University of Sheffield 2002 - 2005: BBSRC Research Development Fellow 1995 - 2001: Lecturer, Dept. of Molecular Biology and Biotechnology, University of Sheffield 1994 - 1995: Staff scientist, MRC Laboratory of Molecular Biology, Cambridge 1990 - 1994: Associate, Department of Biochemistry and Molecular Biology, Harvard University, USA 1989 - 1990: Associate, Howard Hughes Medical Institute, Harvard University, USA 1988 - 1989: Staff scientist, MRC Laboratory of Molecular Biology, Cambridge 1985 - 1988: Ph.D. student, MRC Laboratory of Molecular Biology and Darwin College, University of Cambridge 1982 - 1985: B.Sc. Physics and Biology, King's College, University of London

研究领域

Solving the assembly and structure of large and challenging protein assemblies by high resolution electron microscopy (cryoEM) and X-ray crystallography, in particular bacterial endospores, cell surfaces and membrane protein complexes.

近期论文

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Janganan TK, Mullin N, Tzokov SB, Stringer S, Fagan RP, Hobbs JK, Moir A & Bullough PA (2016) Characterization of the spore surface and exosporium proteins of Clostridium sporogenes; implications for C. botulinum Group I strains. Food Microbiology, 59, 205-212. View this article in WRRO Ma C, Hao Z, Huysmans G, Lesiuk A, Bullough P, Wang Y, Bartlam M, Phillips SE, Young JD, Goldman A, Baldwin SA & Postis VLG (2015) A Versatile Strategy for Production of Membrane Proteins with Diverse Topologies: Application to Investigation of Bacterial Homologues of Human Divalent Metal Ion and Nucleoside Transporters. PLOS ONE, 10(11), e0143010-e0143010. View this article in WRRO Jiang S, Wan Q, Krajcikova D, Tang J, Tzokov SB, Barak I & Bullough PA (2015) Diverse supramolecular structures formed by self-assembling proteins of the Bacillus subtilis spore coat. Molecular Microbiology, 97(2), 347-359. View this article in WRRO Jiang S, Wan Q, Krajcikova D, Tang J, Tzokov SB, Barak I & Bullough PA (2015) Diverse supramolecular structures formed by self-assembling proteins of the B acillus subtilis spore coat. Molecular Microbiology, 97(2), 347-359. View this article in WRRO Adams NBP, Marklew CJ, Qian P, Brindley AA, Davison PA, Bullough PA & Hunter CN (2014) Structural and functional consequences of removing the N-terminal domain from the magnesium chelatase ChlH subunit of Thermosynechococcus elongatus. Biochemical Journal, 464(3), 315-322. View this article in WRRO Yamashita M, Shepherd M, Booth WI, Xie H, Postis V, Nyathi Y, Tzokov SB, Poole RK, Baldwin SA & Bullough PA (2014) Structure and function of the bacterial heterodimeric ABC transporter CydDC: stimulation of ATPase activity by thiol and heme compounds.. J Biol Chem, 289(33), 23177-23188. View this article in WRRO Qian P, Papiz MZ, Jackson PJ, Brindley AA, Ng IW, Olsen JD, Dickman MJ, Bullough PA & Hunter CN (2013) Three-dimensional structure of the Rhodobacter sphaeroides RC-LH1-PufX complex: dimerization and quinone channels promoted by PufX.. Biochemistry, 52(43), 7575-7585.