Barnes, Rebecca - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

Career History 2013 - present: University Teacher, Department of Molecular Biology and Biotechnology, University of Sheffield 2012 - 2013: Associate Research Scientist and Postdoctoral Teaching Scholar, Department of Internal Medicine, Yale University 2012 - 2013: Teaching Affiliate, Gateway Community College, New Haven, CT, USA 2006 - 2012: Postdoctoral Research Associate, Department of Internal Medicine, Yale University 2002 - 2006: PhD Student, Wellcome Centre for Molecular Parasitology, University of Glasgow About I completed a BSc (Hons) in Biochemistry and Genetics at the University of Nottingham in 2002. I then did my PhD in the lab of Dr Richard McCulloch at the Wellcome Centre for Molecular Parasitology, University of Glasgow, where I studied DNA repair systems in the African trypanosome and their role in antigenic variation of the parasite. In 2006 I moved to the USA, joining Prof Elisabetta Ullu’s group at Yale University. There I continued my work on trypanosome molecular biology, examining the molecular mechanisms of RNA interference, as well as being heavily involved in teaching at Yale and in the wider community. I have been working as a teaching specialist in MBB since 2013.

近期论文

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Rodenko B, Wanner MJ, Alkhaldi AAM, Ebiloma GU, Barnes RL, Kaiser M, Brun R, McCulloch R, Koomen G-J & de Koning HP (2015) Targeting the Parasite's DNA with Methyltriazenyl Purine Analogs Is a Safe, Selective, and Efficacious Antitrypanosomal Strategy. Antimicrobial Agents and Chemotherapy, 59(11), 6708-6716. Shi H, Barnes RL, Carriero N, Atayde VD, Tschudi C & Ullu E (2014) Role of the Trypanosoma brucei HEN1 Family Methyltransferase in Small Interfering RNA Modification. Eukaryotic Cell, 13(1), 77-86. Barnes RL, Shi H, Kolev NG, Tschudi C & Ullu E (2012) Comparative Genomics Reveals Two Novel RNAi Factors in Trypanosoma brucei and Provides Insight into the Core Machinery. PLoS Pathogens, 8(5), e1002678-e1002678. Campos PC, Silva VG, Furtado C, Machado-Silva A, DaRocha WD, Peloso EF, Gadelha FR, Medeiros MHG, Lana GDC, Chen Y, Barnes RL, Passos-Silva DG, McCulloch R, Machado CR & Teixeira SMR (2011) Trypanosoma cruzi MSH2: Functional analyses on different parasite strains provide evidences for a role on the oxidative stress response. Molecular and Biochemical Parasitology, 176(1), 8-16. Barnes RL & McCulloch R (2007) Trypanosoma brucei homologous recombination is dependent on substrate length and homology, though displays a differential dependence on mismatch repair as substrate length decreases. Nucleic Acids Research, 35(10), 3478-3493.