张然 - 中国农业大学

个人简介

1999.09-2003.07 沈阳农业大学生物技术专业理学学士学位 2003.09-2009.06 中国农业大学生化与分子生物学专业理学博士学位 2007.09-2008.09 瑞典卡罗林斯卡医学院临床免疫系博士联合培养 2009.07-至今中国农业大学生物学院讲师，副教授

研究领域

基因修饰疾病动物模型制备及其分子机制研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Han Q, Chen H, Wang L, An Y, Hu X, Zhao Y, Zhang H, Zhang R*. Systemic Deficiency of GHR in Pigs leads to Hepatic Steatosis via Negative Regulation of AHR Signaling. Int J Biol Sci. 2021 Oct 3;17(15):4108-4121. Xue Z, Han Q, Huang P, Jiang X, Tan M, Zhao Y, Li N, Zhang R*. Characterization of Functional Components in Bovine Colostrum That Inhibit Norovirus Capsid Protruding Domains Interacting with HBGA Ligands. Pathogens. 2021 Jul 7;10(7):857. Zhang R, Tang C, Guo H, Tang B, Chen Z, Dai Y, Li N. A novel glycosylated anti-CD20 monoclonal antibody from transgenic cattle. Sci Rep. 2018 Sep 4;8(1):13208. Zheng Y, Song Y, Han Q, Liu W, Xu J, Yu Z, Zhang R*, Li N. IEC-specific IGF1 promotes the expansion of intestinal stem cells during epithelial regeneration and functions on the intestinal immune homeostasis. Am J Physiol Endocrinol Metab, 2018 Oct 1;315(4):E638-E649. Cui D, Li F, Li Q, Li J, Zhao Y, Hu X, Zhang R*, Li N*. Generation of a iniature pig disease model for human Laron syndrome. Sci Rep. 2015 Oct 29;5:15603. Cui D, Zhang L, Li J, Zhao Y, Hu X, Dai Y, Zhang R*, Li N*. Bovine FcRn-mediated human immunoglobulin G transfer across the milk-blood barrier in transgenic mice. PLoS One. 2014 Dec 29;9(12):e115972. Günayd?n G, Zhang R, Hammarstr?m L, Marcotte H. Engineered Lactobacillus rhamnosus GG expressing IgG-binding domains of protein G: Capture of hyperimmune bovine colostrum antibodies and protection against diarrhea in a mouse pup rotavirus infection model. Vaccine. 2014 Jan 16;32(4):470-7. Zhang R, Yin Y, Zhang Y, Li K, Zhu H, Gong Q, Wang J, Hu X, Li N. Molecular characterization of transgene integration by next-generation sequencing in transgenic cattle. PLoS One. 2012;7(11):e50348. Zhang R, Guo C, Sui S, Yu T, Wang J, Li N. Comprehensive assessment of milk composition in transgenic cloned cattle. PLoS One. 2012;7(11):e49697. Zhang R, Cui D, Wang H, Li C, Yao X, Zhao Y, Liang M, Li N. Functional recombinant human anti-HBV antibody expressed in milk of transgenic mice. Transgenic Res. 2012 Oct;21(5):1085-91. Zhang R, Zhao Z, Zhao Y, Kacskovics I, Eijk Mv, Groot Nd, Li N, Hammarstrom L. Association of FcRn Heavy Chain Encoding Gene (FCGRT) Polymorphisms with IgG Content in Bovine Colostrum. Anim Biotechnol. 2009;20(4):242-6. Zhang R, Rao M, Li C, Cao J, Meng Q, Zheng M, Wang M, Dai Y, Liang M, Li N. Functional recombinant human anti-HAV antibody expressed in milk of transgenic mice. Transgenic Res. 2009 Jun;18(3):445-53.