Baker, Patrick - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

2015 - Present: Director Of Studies and Deputy Head of Department, Dept of Molecular Biology and Biotechnology, The University of Sheffield 2010 - Present: Senior Lecturer, Dept of Molecular Biology and Biotechnology, The University of Sheffield 2010: Visiting Lecturer, Dept Bioquimica, Faculdad Sciencias, The University of Alicante, Spain 2008 -2010: Lecturer, Dept. of Molecular Biology and Biotechnology, The University of Sheffield 1993 -2010: Senior Experimental Officer (X-ray facility manager) in the Krebs Institute, University of Sheffield 1987-1993: Postdoctoral Research Associate, Dept. of Biochemistry, The University of Sheffield 1984-1987: PhD. Student, Dept. of Biochemistry, The University of Sheffield 1982-1984: Research Assistant, Dept. of Clinical Haematology, University College, London.

研究领域

Use of protein crystallography to study the structure/function relationships in biological macromolecules, including substrate specificity and chiral synthesis in enzymes and the molecular basis of stability in proteins from extremophiles.

近期论文

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Bisson C, Britton KL, Sedelnikova SE, Rodgers HF, Eadsforth TC, Viner RC, Hawkes TR, Baker PJ & Rice DW (2016) Mirror-Image Packing Provides a Molecular Basis for the Nanomolar Equipotency of Enantiomers of an Experimental Herbicide.. Angew Chem Int Ed Engl. View this article in WRRO Denby KJ, Iwig J, Bisson C, Westwood J, Rolfe MD, Sedelnikova SE, Higgins K, Maroney MJ, Baker PJ, Chivers PT & Green J (2016) The mechanism of a formaldehyde-sensing transcriptional regulator.. Scientific Reports, 6. View this article in WRRO Bisson C, Britton KL, Sedelnikova SE, Rodgers HF, Eadsforth TC, Viner RC, Hawkes TR, Baker PJ & Rice DW (2015) Crystal Structures Reveal that the Reaction Mechanism of Imidazoleglycerol-Phosphate Dehydratase Is Controlled by Switching Mn(II) Coordination. Structure, 23(7), 1236-1245. View this article in WRRO Zhang R, Zeng X, Kim B, Bushby RJ, Shin K, Baker PJ, Percec V, Leowanawat P & Ungar G (2015) Columnar Liquid Crystals in Cylindrical Nanoconfinement. ACS Nano, 9(2), 1759-1766. View this article in WRRO Almourfi FM, Rodgers HF, Sedelnikova SE & Baker PJ (2015) Crystallization and preliminary crystallographic analysis of the putative sugar-binding protein Msmeg_0515 (AgaE) from Mycobacterium smegmatis. Acta Crystallographica Section F Structural Biology Communications, 71(2), 189-193. Ramly NZ, Rouzheinikov SN, Sedelnikova SE, Baker PJ, Chow YP, Wan KL, Nathan S & Rice DW (2013) Crystallization and preliminary crystallographic analysis of a surface antigen glycoprotein, SAG19, from Eimeria tenella.. Acta Crystallogr Sect F Struct Biol Cryst Commun, 69(Pt 12), 1380-1383. Abd Aziz AG, Sedelnikova SE, Ruzheinikov SN, Thorpe S, Mohamed R, Nathan S, Rafferty JB, Baker PJ & Rice DW (2012) Crystallization and preliminary X-ray analysis of the receiver domain of a putative response regulator, BPSL0128, from Burkholderia pseudomallei.. Acta Crystallogr Sect F Struct Biol Cryst Commun, 68(Pt 8), 917-922. Abd Aziz AG, Ruzheinikov SN, Sedelnikova SE, Mohamed R, Nathan S, Baker PJ & Rice DW (2012) Cloning, purification, crystallization and preliminary X-ray analysis of the Burkholderia pseudomallei L1 ribosomal protein.. Acta Crystallogr Sect F Struct Biol Cryst Commun, 68(Pt 3), 347-350. Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, Marshall LE, Mobbs GW, Mohamed R, Nathan S, Ngugi SA, Ong C, Ooi WF, Partridge LJ, Phillips HL, Raih MF, Ruzheinikov S, Sarkar-Tyson M, Sedelnikova SE, Smither SJ, Tan P, Titball RW, Wilson SA & Rice DW (2011) A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.. Science, 334(6057), 821-824.