Goldman, Alastair - University of Sheffield - Department of Molecular Biology and Biotechnology

个人简介

2012 - present: Professor Dept. of Molecular Biology and Biotechnology, The University of Sheffield 2002 - 2012: Senior Lecturer, Dept. of Molecular Biology and Biotechnology, The University of Sheffield 1997 - 2002:Lecturer, Dept. of Molecular Biology and Biotechnology, The University of Sheffield 1993 - 1997: Postdoctoral Fellow, National Institutes of Health, Bethesda, MD, USA. 1989 - 1993: Research Assistant (and postgraduate student), Regional Genetics Services, East Birmingham Hospital, England.

研究领域

Genetic and molecular analysis of DNA double-strand break (DSB) repair in meiosis, using yeast as a model organisation. Analysis of testis cancer antigens expression in cancer cells, and determination of its significance.

近期论文

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Medhi D, Goldman ASH & Lichten M (2016) Local chromosome context is a major determinant of crossover pathway biochemistry during budding yeast meiosis. eLife, 5. Penedos A, Johnson AL, Strong E, Goldman AS, Carballo JA & Cha RS (2015) Essential and Checkpoint Functions of Budding Yeast ATM and ATR during Meiotic Prophase Are Facilitated by Differential Phosphorylation of a Meiotic Adaptor Protein, Hop1. PLOS ONE, 10(7), e0134297-e0134297. Lafta IJ, Bryant HE & Goldman ASH (2014) ‘Sex’ in the cancer cell. Oncotarget, 5(18), 7984-7985. Gray S, Allison RM, Garcia V, Goldman ASH & Neale MJ (2013) Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR). Open Biology, 3(JUL). Penfold CA, Brown PE, Lawrence ND & Goldman AS (2012) Modeling meiotic chromosomes indicates a size dependent contribution of telomere clustering and chromosome rigidity to homologue juxtaposition.. PLoS Comput Biol, 8(5), e1002496. View this article in WRRO Keelagher RE, Cotton VE, Goldman ASH & Borts RH (2011) Separable roles for Exonuclease I in meiotic DNA double-strand break repair. DNA Repair, 10(2), 126-137. Hodgson A, Terentyev Y, Johnson RA, Bishop-Bailey A, Angevin T, Croucher A & Goldman AS (2011) Mre11 and Exo1 contribute to the initiation and processivity of resection at meiotic double-strand breaks made independently of Spo11.. DNA Repair (Amst), 10(2), 138-148. Blundred R, Myers K, Helleday T, Goldman AS & Bryant HE (2010) Human RECQL5 overcomes thymidine-induced replication stress.. DNA Repair (Amst), 9(9), 964-975. Terentyev Y, Johnson R, Neale MJ, Khisroon M, Bishop-Bailey A & Goldman AS (2010) Evidence that MEK1 positively promotes interhomologue double-strand break repair.. Nucleic Acids Res, 38(13), 4349-4360. Johnson R, Borde V, Neale MJ, Bishop-Bailey A, North M, Harris S, Nicolas A & Goldman ASH (2007) Excess single-stranded DNA inhibits meiotic double-strand break repair.. PLoS genetics, 3(11). View this article in WRRO Lundin C, North M, Erixon K, Walters K, Jenssen D, Goldman ASH & Helleday T (2005) Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks. NUCLEIC ACIDS RES, 33(12), 3799-3811. View this article in WRRO