陈芝 - 中国农业大学

个人简介

陈芝博士，微生物学与免疫学系副教授。主要从事抗生素生物合成调控和裂殖壶菌高产DHA的代谢工程育种等研究。学习与工作经历 2007/1-现在：中国农业大学，生物学院微生物学系，副教授 2004/04-2006/12：中国农业大学，生物学院微生物学系，讲师 2002/09-2003/10：德国Osnabruck University，博士后 1997/09-2002/07：中国农业大学，微生物学专业，博士 1993/09-1997/07：中国农业大学，微生物学专业，学士获奖情况中国农业大学教学成果二等奖（排名第二）（2012）中国农业大学优秀教师（2009）微生物农药发酵新技术新工艺及重要产品规模应用国家科技进步奖二等奖二级证书获得者（2006）

研究领域

次级代谢产物生物合成调控代谢工程育种

近期论文

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Yaqing Cheng, Renjun Yang, Mengya Lyu, Shiwei Wang, Xingchao Liu, Ying Wen, Yuan Song, Jilun Li, & Zhi Chen*. IdeR, a DtxR-family iron-response regulator, controls iron homeostasis, morphological differentiation, secondary metabolism, and oxidative stress response in Streptomyces avermitilis. 2018. Applied and Environmental Microbiology. In press. (通讯作者) Sun M, Lyu M, Wen Y, Song Y, Li J, Chen Z*. Organic Peroxide-Sensing Repressor OhrR Regulates Organic Hydroperoxide Stress Resistance and Avermectin Production in Streptomyces avermitilis. Front Microbiol. 2018 9:1398. （通讯作者） Anping Su, Shuang Chi, Ying Li, Siyuan Tan, Shan Qiang, Zhi Chen*, and Yonghong Meng*. Metabolic Redesign of Rhodobacter sphaeroides for Lycopene Production. Journal of Agricultural and Food Chemistry 2018 66 (23):5879-5885. (共同通讯作者) Xingchao Liu, Yaqing Cheng, Mengya Lyu, Ying Wen, Yuan Song, Zhi Chen*, & Jilun Li. Redox-sensing regulator Rex regulates aerobic metabolism, morphological differentiation, and avermectin production in Streptomyces avermitilis. Sci. Rep. 2017; 7, 44567; doi: 10.1038/srep44567. （通讯作者） Xingchao Liu，Meng Sun, Yaqing Cheng, Renjun Yang, Ying Wen, Zhi Chen*, Jilun Li. OxyR is a key regulator in response to oxidative stress in Streptomyces avermitilis. Microbiology-SGM. 2016. 162:707-716. （通讯作者） Yang Renjun, Xingchao Liu, Ying Wen, Yuan Song, Zhi Chen *, Jilun Li. The PhoP transcription factor negatively regulates avermectin biosynthesis in Streptomyces avermitilis. Appl Microbiol Biotechnol. 2015 Dec; 99(24):10547-57. （通讯作者） Yanping Liu, Tingting Yan, Libin Jiang, Ying Wen, Yuan Song, Zhi Chen*, Jilun Li. Characterization of SAV7471, a TetR-family transcriptional regulator involved in the regulation of coenzyme A metabolism in Streptomyces avermitilis. J Bacteriol. 2013 Oct; 195(19):4365-72. （通讯作者） Libin Jiang, Yanping Liu, Pan Wang, Ying Wen, Yuan Song, Zhi Chen*, Jilun Li. Inactivation of the extracytoplasmic function sigma factor Sig6 stimulates avermectin production in Streptomyces avermitilis. Biotechnol Lett. 2011. 33:1955–1961. （通讯作者） Zhi Chen, Wen Jia, Song Yuan*, Wen Ying and Li Jilun*. Enhancement and selective production of avermectin B by recombinants of Streptomyces avermitilis via intraspecific protoplast fusion. Chinese Science Bulletin. 2007. 52(5):616-622 Zhi Chen, Lin Wen, Yu Ping and Song Yuan*. Enhancement of Monacolin K production via intergenric protoplast fusion between Aspergillus terreus and Monascus anka. Progress in Natural Science. 2007. 17(6):703-707. 陈芝，宋渊，文莹，李季伦*.阿维链霉菌次级代谢研究进展与展望. 自然科学进展. 2007. 17(3):290-296.