毕国志 - 中国农业大学

个人简介

毕国志博士，教授，博士生导师，2022年以“杰出人才”引进中国农业大学。学习与工作经历 2022/4-至今，中国农业大学生物学院，教授 2020/11-2022/3，中国科学院遗传与发育生物学研究所，副研究员 2015/7-2020/11，中国科学院遗传与发育生物学研究所，博士后 2012/9-2015/4，Wageningen大学，联培博士 2011/9-2015/7，东北农业大学，农学博士学位 2008/9-2011/7，东北农业大学，农学硕士学位 2004/9-2008/7，东北农业大学，农学学士学位

研究领域

植物病害是制约农作物生产的重要因素之一。本实验室主要研究方向为植物与病原微生物互作。一方面以拟南芥为实验材料，综合运用分子生物学、遗传学和生物化学等手段，解析信号分子活性氧调控植物免疫的分子机制，深入理解免疫信号网络，为植物抗病的分子设计提供新靶标和新策略。另一方面以玉米为研究材料，通过正向、反向遗传学，分离及鉴定玉米抗病基因，并阐明分子机制，为培育抗病新品种提供重要的基因资源

近期论文

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Bi G#*, Hu M#, Fu L#, Zhang X, Zuo J, Li J, Yang J*, Zhou J-M*. (2022) The cytosolic thiol peroxidase PRXIIB is an intracellular sensor for H2O2 that regulates plant immunity through a redox relay, Nat Plants, 8: 1160–1175 Bi G#, Su M#, Li N#, Liang Y, Dang S, Xu J, Hu M, Wang J, Zou M, Deng Y, Li Q, Huang S, Li J, Chai J*, He K*, Chen Y-H*, Zhou J-M*. (2021) The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling, Cell, 184: 3528-3541 Bi G, Zhou J-M. (2021) Regulation of cell death and signaling by pore-forming resistosomes, Annu Rev Phytopathol, 59: 239-263 Hu M#, Qi J#, Bi G*, Zhou J-M*. (2020) Bacterial effectors induce oligomerization of immune receptor ZAR1 in vivo, Mol Plant, 13: 793-801 Bi G#, Zhou Z#, Wang W#, Li L, Rao S, Wu Y, Zhang X, Menke F, Chen S, Zhou J-M. (2018) Receptor-like cytoplasmic kinases directly link diverse pattern recognition receptors to the activation of mitogen-activated protein kinase cascades in Arabidopsis, Plant Cell, 30: 1543-1561 Bi G, Zhou J-M. (2017) MAP kinase signaling pathways: a hub of plant-microbe interactions, Cell Host Microbe, 21: 270-273 Bi G, Liebrand T, Bye R, Postma J, Burgh A, Robatzek S, Xu X*, Joosten M*. (2016) SOBIR1 requires the GxxxG dimerization motif in its transmembrane domain to form constitutive complexes with receptor-like proteins, Mol Plant Pathol, 17: 96-107 部分合作文章 Yuan M, Jiang Z, Bi G, Nomura K, Liu M, Wang Y, Cai B, Zhou J-M, He S, Xin X-F.(2021) Pattern-recognition receptors are required for NLR-mediated plant immunity, Nature, 592: 105-109 Zhou Z, Zhao Y, Bi G, Liang X, Zhou Jian-Min. (2019) Early signalling mechanisms underlying receptor kinase-mediated immunity in plants, Philos Trans R Soc Lond B Biol Sci, 374: 20180310 Zhou Z, Bi G, Zhou Jian-Min; Luciferase complementation assay for protein-protein interactions in plants, Curr Protoc plant Biol, 2018, 3(1): 42-50 Liang X, Ma M, Zhou Z, Wang J, Yang X, Rao S, Bi G, Li L, Zhang X, Chai J, Chen S, Zhou J-M. (2018) Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases, Cell Res, 28(5): 529-543 Wu J, Burgh A, Bi G, Zhang L, Alfano J, Martin G, Joosten M. (2018) The bacterial effector AvrPto targets the regulatory co-receptor SOBIR 1 and suppresses defence signalling mediated by the receptor-like protein Cf-4, Mol Plant Microbe Interact, 31(1): 75-85 Rao S, Zhou Z, Miao P, Bi G, Hu M, Wu Y, Feng F, Zhang X, Zhou J-M. (2018) Roles of receptor-like cytoplasmic kinase VII members in pattern-triggered immune signaling, Plant Physiol, 177: 1679-16903. Postma J, Liebrand T, Bi G, Evrard A, Bye R, Mbengue M, Kuhn H, Joosten M, Robatzek S. (2016) Avr4 promotes Cf-4 receptor-like protein association with the BAK1/SERK3 receptor-like kinase to initiate receptor endocytosis and plant immunity, New Phytol, 210: 627-642