王献兵 - 中国农业大学

个人简介

王献兵中国农业大学生物学院微生物系与免疫学系，植物抗逆高效全国重点实验室教授，博士生导师。主要从事植物病毒与寄主植物以及昆虫介体之间复杂性互作关系研究。2013年获得国家自然科学基金优秀青年科学基金，2017年入选北京市科技新星计划。近年来以第一作者或者通讯作者在Nature Communications（2023a,2023b），The EMBO Journal (2021), PNAS (2010)、The Plant Cell (2011, 2020, 2022)、eLife (2020, 2022)、New Phytologist (2019)、PLoS Pathogens (2017)、Plant Physiology (2017, 2022)、Journal of Experimental Botany (2019, 2020), Molecular Plant Pathology (2016)等期刊上发表多篇研究论文。学习与工作经历 1999/09－2003/06，中国农业大学，生物科学专业，理学学士学位 2003/09－2009/06，中国农业大学，生物化学与分子生物学，理学博士学位 2007/10－2009/12，美国加州大学河滨分校，植物病理系，访问博士生 2009/12－2012/07，美国加州大学河滨分校，植物病理系，博士后 2012/12－至今，中国农业大学生物学院教授获奖情况 2016年度中国植物病理学会青年植物病理学家奖承担项目及课题 2024.01-2027.12 国家自然科学基金面上项目，主持 2019.01-2022.12 国家自然科学基金面上项目，主持 2017.01-2019.12 北京市科技新星，主持 2016.07-2018.12 重点研发计划子课题，主持 2016.01-2019.12 国家自然科学基金面上项目，主持 2014.01-2017.12 国家自然科学基金面上项目，主持 2014.01-2016.12 国家自然科学基金优秀青年科学基金，主持 2014.01-2016.12 教育部博士点基金，主持社会兼职中国植物病理学会理事中国植物病理学会植物与病原物互作专业委员会副主任委员中国昆虫学会媒介昆虫于病原互作专委会委员中国微生物学会病毒学专业委员会委员

研究领域

重大虫传植物病毒病害是制约我国粮食等作物高产稳产的重要因素，严重威胁着我国粮食安全和农业可持续发展。本课题组主要从事植物病毒与植物寄主或昆虫介体的互作机理等应用基础研究。具体研究主要包括：(1) 细胞质弹状病毒大麦黄条点花叶病毒（BYSMV)——小麦、玉米等农作物——灰飞虱介体三者的复杂性互作关系；(2) 黄瓜花叶病毒(CMV)——模式植物拟南芥之间侵染与防御的分子机制；(3) 从抗感性品种材料分离鉴定抗感病相关基因；(4) 以CMV和BYSMV为基础的病毒载体及相关生物反应器

近期论文

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Gao, D.M., Qiao, J.H., Gao, Q., Zhang, J., Zang, Y., Xie, L., Zhang, Y., Wang, Y., Fu, J., Zhang, H., Han, C., and Wang, X.B.* (2023). A plant cytorhabdovirus modulates locomotor activity of insect vectors to enhance virus transmission. Nature communications 14, 5754. Tong, X.#, Zhao, J.J.#, Feng, Y.L., Zou, J.Z., Ye, J., Liu, J., Han, C., Li, D., and Wang, X.B.* (2023). A selective autophagy receptor VISP1 induces symptom recovery by targeting viral silencing suppressors. Nature Communications 14, 3852. Tong, X., Zhao, J.J., Feng, Y.L., and Wang, X.B.* (2023). The small peptide VISP1 acts as a selective autophagy receptor regulating plant-virus interactions. Autophagy. DOI: 10.1080/15548627.2023.2246858 (Autophagic punctum). Ding Z.H., Gao, Q, Tong, X., Xu, W.Y., Ma, L., Zhang, Z.J., Wang, Y., Wang, X.B.* (2022). MAPKs trigger antiviral immunity by directly phosphorylating a rhabdovirus nucleoprotein in plants and insect vectors. The Plant Cell, 34(8): 3110-3127. Fang X.D., Gao Q., Zang Y., Qiao J.H., Gao D.M., Xu W.Y., Wang Y., Li D., Wang, X.B. * (2022). Host casein kinase 1-mediated phosphorylation modulates phase separation of a rhabdovirus phosphoprotein and virus infection. eLife. 11: e74884. Gao, D.M, Zhang, Z.J., Qiao J.H., Gao, Q, Zang, Y, Xu, W. Y., Xie, L., Fang, X.D., Ding, Z.H., Yang, Y.Z., Wang Y, Wang, X.B.* (2022) A rhabdovirus accessory protein inhibits jasmonic acid signaling in plants to attract insect vectors. Plant Physiology, 190: 1349-1364. Tong, X., Liu, S.Y., Zou, J.Z., Zhao, J.J., Zhu, F.F., Chai, L.X., Wang, Y., Han, C., Wang, X.B.* (2021). A small peptide inhibits siRNA amplification in plants by mediating autophagic degradation of SGS3/RDR6-bodies. The EMBO Journal, 40: e108050. Gao, Q.#, Yan, T.#, Zhang, Z.-J.#, Liu, S.-Y., Fang, X.D., Gao, D.-M., Yang, Y.Z., Xu, W.-Y., Qiao, J.-H., Cao, Q., Ding, Z.H., Wang,Y., Yu, J.L., Wang, X.B.* (2020). Casein Kinase 1 regulates cytorhabdovirus replication and transcription by phosphorylating a phosphoprotein serine-rich motif. The Plant Cell, 32(9): 2878-2897. Zhang, Z.J., Gao, Q., Fang, X.D., Ding, Z.H., Gao, D.M., Xu, W.Y., Cao, Q., Qiao, J.H., Yang, Y.Z., Han, C., Wang,Y., Yuan, X., Li, D., Wang, X.B.* (2020). CCR4, a RNA decay factor, is hijacked by a plant cytorhabdovirus phosphoprotein to facilitate virus replication. eLife, 9: e53753. Chai, L.X., Dong, K., Liu, S.Y., Zhang, Z., Zhang, X.P., Tong, X., Zhu, F.F., Zou, J.Z., Wang, X.B.* (2020). A putative nuclear copper chaperone promotes plant immunity in Arabidopsis. Journal of Experimental Botany, 71(20): 6684-6696. Gao, Q#, Xu, W.Y#, Yan, T, Fang, X.D., Cao, Q, Zhang, Z-J, Ding, Z-H, Wang, Y, Wang, X.B.* (2019). Rescue of a plant cytorhabdovirus as versatile expression platforms for planthopper and cereal genomic studies. New Phytologist, 223: 2120-2133. 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The 21-nucleotide, but not 22-nucleotide, viral secondary small interfering RNAs direct potent antiviral defense by two cooperative argonautes in Arabidopsis thaliana. The Plant Cell 23: 1625-1638. 其他主要作者文章(#共同第一作者, *通讯作者) Fang, X.D., Qiao, J.H., Zang, Y., Gao, Q., Xu, W.Y., Gao, D.M., Yang, Y.Z., Xie, L., Wang, Y., and Wang, X.B.* (2022). Developing reverse genetics systems of northern cereal mosaic virus to reveal superinfection exclusion of two cytorhabdoviruses in barley plants. Mol Plant Pathol. 23: 749-756. Xu, W.Y., Fang, X.D., Cao, Q., Gao, Q., Gao, D.M., Qiao, J.H., Zang, Y., Xie, L., Ding, Z.H., Yang, Y.Z., Wang, Y., and Wang, X.B.* (2022). A cytorhabdovirus-based expression vector in Nilaparvata lugens, Laodelphax striatellus, and Sogatella furcifera. Insect Biochem Mol Biol 140: 103703. Qiao, J.H., Gao, Q., Zang, Y., Fang, X.D., and Wang, X.B.* (2022). A Versatile Expression Platform in Insects and Cereals Based on a Cytorhabdovirus. Plant Virology. Humana, New York, 163-170. Zou, J. Z., Liu, D. S., Tong, X., Zhang, X. P., and Wang, X.B.* (2022). RNA In Situ Hybridization of Detecting Cucumber Mosaic Virus in Shoots of Nicotiana benthamiana Plants. Plant Virology. Humana, New York, 283-296. Gao, Q., Xuehelati, R., Wang, Y., Li, K.*, and Wang, X.B.* (2021). Identification of Alfalfa dwarf virus in Xinjiang Province, China. Plant Disease, PDIS-02-21-0379-PDN. Zang, Y., Fang, X.D., Qiao, J.H., Gao, Q., Wang, X.B.* (2020). Reverse genetics systems of plant negative-strand RNA viruses are difficult to be developed but powerful for virus-host interaction studies and virus-based vector applications. Phytopathology Research, 2: 29. Zhang Z, Tong X, Liu SY, Chai LX, Zhu FF, Zhang XP, Zou JZ, Wang, X.B.* (2019). Genetic analysis of a Piezo-like protein suppressing systemic movement of plant viruses in Arabidopsis thaliana. Scientific Report, 9(1): 3187. Cao, Q., Xu, W.-Y., Gao, Q., Jiang, Z.-H., Liu, S.-Y., Fang, X.-D., Gao, D.-M., Wang, Y., Wang, X.B.* (2018). Transmission characteristics of barley yellow striate mosaic virus in its planthopper vector Laodelphax striatellus. Frontiers in microbiology 9: 1419. Guo, Z.#, Wang, X.B.#*, Wang, Y., Li, W.-X., Gal-On, A., and Ding, S.-W.* (2017). Identification of a new host factor required for antiviral RNAi and amplification of viral siRNAs. Plant Physiology, 176: 1587-1597. Dong, K.#, Wang, Y.#, Zhang, Z., Chai, L.X., Tong, X., Xu, J., Li, D., and Wang, X.B.* (2016). Two amino acids near the N-terminus of Cucumber mosaic virus 2b play critical roles in the suppression of RNA silencing and viral infectivity. Molecular Plant Pathology, 17: 173-183. Yan, T., Zhu, J. R., Di, D., Gao, Q., Zhang, Y., Zhang, A,. Yan, C., Miao, H. and Wang, X.B.* 2015. Characterization of the complete genome of Barley yellow striate mosaic virus reveals a nested gene encoding a small hydrophobic protein. 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Interaction between Brassica yellows virus silencing suppressor P0 and plant SKP1 facilitates stability of P0 in vivo against degradation by proteasome and autophagy pathways. New Phytologist, 222(3): 1458-1473. Yang, M., Zhang, Y., Xie, X., Yue, N., Li, J., Wang, X. B., Han, C., Yu, J., Liu, Y., and Li, D. (2018). Barley stripe mosaic virus γb protein subverts autophagy to promote viral infection by disrupting the ATG7-ATG8 interaction. The Plant Cell, 30(7) : 1582-1595. Wu, D., Qi, T., Li, W.X., Tian, H., Gao, H., Wang, J., Ge, J., Yao, R., Ren, C., Wang, X.B., Liu, Y., Kang, L., Ding, S.W., Xie, D., (2017). Viral effector protein manipulates host hormone signaling to attract insect vectors. Cell Research, 27: 402-415. Zhang, K., Zhang, Y., Yang, M., Liu, S., Li, Z., Wang, X.B., Han, C., Yu, J., Li, D., (2017). The barley stripe mosaic virus gammab protein promotes chloroplast-targeted replication by enhancing unwinding of RNA duplexes. PLoS Pathogens, 13: e1006319. Cao M, Du P, Wang X.B., Yu YQ, Qiu YH, Li W, Gal-On A, Zhou C, Li Y, Ding SW. 2014. Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis. Proc Natl Acad Sci U S A 111: 14613-14618. Qiao, Q.L., Liu, L., Xiong, Q., Flores, C., Wong, J., Shi, J., Wang, X.B., Liu, X., Jiang, S., Zhang, F., Wang, Y.C., Judelson, H.S., Chen, X.M. and Ma, W.B. 2013. Oomycete pathogens encode RNA silencing suppressors. Nature genetics 38: 258-263. Xu, J., Wang, X.B., Shi, L., Zhou, Y., Li, D., Han, C., Zhang, Z., and Yu, J. 2012. Two distinct sites are essential for virulent infection and support of variant satellite RNA replication in spontaneous Beet black scorch virus variants. Journal of General Virology 93: 2718-2728. Wu, Q., Wang, X.B., and Ding, S.W. 2010. Viral suppressors of RNA-based viral immunity: host targets. Cell host & microbe 8: 12-15.