个人简介
侯云鹏 博士，副教授，博士生导师。2008年12月至今，任中国农业大学生物学院副教授，主要研究哺乳动物（猪、牛和鼠）卵母细胞成熟和发育的钙稳态调节机理，环境与药物对生殖生理的干扰影响。
学习与工作经历
2006/07－至今，中国农业大学生物学院，讲师、副教授
2001/09－2006/06，中国农业大学动物科技学院，农学博士学位
1994/09－1998/06，中国农业大学动物科技学院，农学学士学位
主讲课程
《探索生命的奥秘》（一年级本科生）、《生物学方法论》（二/三年级本科生）和《生物产业与就业》（四年级本科生）
获奖情况
2007年获得北京市青年科技论文一等奖
2013年获得北京市高等教育教学成果奖二等奖（3/6）
承担项目及课题
国家科技重大专项，30972101，MSTN敲除肉牛营养与饲养管理，2016/01-2020/12，已结题，主持
国家科技重大专项，2013ZX08007002-002，MSTN敲除肉牛生产及生物安全评价，2013/01-2013/12，已结题，主持
国家自然科学基金面上项目，30972101，牛卵母细胞冷冻前后CD9表达量对精卵结合的影响，2010/01-2012/12，已结题，主持
研究领域
大量研究证实[Ca2+]i在卵母细胞减数分裂，激活，受精及早期胚胎发育过程中起着重要的调控作用，其稳态的维持对于卵母细胞正常机能至关重要。本人主要通过分子生物学、细胞生物学和生物化学等手段，研究哺乳动物（猪、牛和鼠）卵母细胞钙稳态调节机理，为生殖生物学提供理论支撑，为动物生物技术研究提供充足的卵母细胞资源。（一）以卵母细胞膜为研究材料，系统研究膜上蛋白识别调控钙离子出入的生理及分子机制；（二）以胞质、内质网和线粒体为研究材料，通过调节钙库中钙离子释放和收集研究卵母细胞生理变化机制，及其对未来胚胎重编程及发育的影响；（三）以雌性小鼠为研究材料，通过体内饲喂或体外培养体系中添加药物或环境中有毒有害物质，研究药物和环境对雌性生殖生理干扰及机制。
近期论文
查看导师新发文章
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The Role of Ca2+ in Maturation and Reprogramming of Bovine Oocytes: A System Study of Low-Calcium Model Authors (9): Meng, Lin#; Hu, Hongmei#...Hou, Yunpeng* Published: Oct 2021in Frontiers in Cell and Developmental Biology DOI: 10.3389/FCELL.2021.746237
Polystyrene Microplastics Induced Female Reproductive Toxicity in Mice Authors (6): Zhiqiang Liu; Qingrui Zhuan ... Yunpeng Hou* Published: Oct 2021in Journal of Hazardous Materials DOI: 10.1016/J.JHAZMAT.2021.127629
Mitochondrial Calcium uniporters are essential for meiotic progression in mouse oocytes by controlling Ca2+ entry Authors (8): Lu Yao Zhang#; Meng Lin#... Hou, Yunpeng* Published: Sep 2021in Cell Proliferation DOI: 10.1111/CPR.13127
The Calcium-Sensing Receptor Is Involved in Follicle-Stimulating HormoneInduced Cumulus Expansion in in vitro Cultured Porcine Cumulus-Oocyte Complexes Authors (8): Liu, Huage#; Zhou, Dan#... Hou, Yunpeng* Published: May 2021in Frontiers in Cell and Developmental Biology DOI: 10.3389/FCELL.2021.625036
Mitochondrial Ca2+ Overload Leads to Mitochondrial Oxidative Stress and Delayed Meiotic Resumption in Mouse Oocytes Authors (7): Zhang, Luyao; Wang, Zichuan ... Hou, Yunpeng* Published: Dec 2020in Frontiers in Cell and Developmental Biology DOI: 10.3389/FCELL.2020.580876
Dihydroartemisinin exposure impairs porcine ovarian granulosa cells by activating PERK-eIF2 alpha-ATF4 through endoplasmic reticulum stress Authors (7): Luo, Yan; Guo, Qing ... Hou, Yunpeng* Published: Sep 2020in Toxicology and Applied Pharmacology DOI: 10.1016/J.TAAP.2020.115159
The extracellular calcium-sensing receptor promotes porcine egg activation via calcium/calmodulin-dependent protein kinase II Authors (8): Liu, Cong; Liu, Huage ... Hou, Yunpeng* Published: May 2020in Molecular Reproduction & Development DOI: 10.1002/MRD.23322
Toxic effects of 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal on the reproduction of female mice Authors (5): Liu, Huage; Liu, Zhiqiang ... Hou, Yunpeng* Published: Nov 2019in Ecotoxicology and Environmental Safety DOI: 10.1016/J.ECOENV.2019.109544
Toxic effects of 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal on the maturation and subsequent development of murine oocyte Authors (7): Liu, Huage; Liu, Zhiqiang ... Hou, Yunpeng* Published: Oct 2019in Ecotoxicology and Environmental Safety DOI: 10.1016/J.ECOENV.2019.06.006
Toxicity and related mechanisms of dihydroartemisinin on porcine oocyte maturation in vitro Authors (6): Luo, Yan; Che, Man-Ju ... Hou, Yunpeng* Published: Feb 2018in Toxicology and Applied Pharmacology DOI: 10.1016/J.TAAP.2018.01.002
BAPTA-AM dramatically improves maturation and development of bovine oocytes from grade-3 cumulus-oocyte complexes Authors (5): Hu, Hongmei; Mo, Xianhong ... Hou, Yunpeng* Published: Jan 2018in Molecular Reproduction & Development DOI: 10.1002/MRD.22936
Enriched endoplasmic reticulum-mitochondria interactions result in mitochondrial dysfunction and apoptosis in oocytes from obese mice Authors (6): Zhao, Lihong; Lu, Tengfei ... Hou, Yunpeng* Published: Aug 2017in Journal of Animal Science and Biotechnology DOI: 10.1186/S40104-017-0195-Z
The Extracellular Calcium-Sensing Receptor (CASR) Regulates GonadotropinsInduced Meiotic Maturation of Porcine Oocytes Authors (8): Liu, Cong; Wu, Guo-Quan ... Hou, Yunpeng* Published: Dec 2015in Biology of Reproduction DOI: 10.1095/BIOLREPROD.115.128579
Leukemia Inhibitory Factor Enhances Bovine Oocyte Maturation and Early Embryo Development Authors (7): Mo, Xianhong; Wu, Guoquan ... Hou, Yunpeng* Published: Jul 2014in Molecular Reproduction & Development DOI: 10.1002/MRD.22327
Nuclear maturation and embryo development of porcine oocytes vitrified by cryotop: Effect of different stages of in vitro maturation Authors (7): Wu, Guoquan; Jia, Baoyu ... Hou, Yunpeng* Published: Aug 2013in Cryobiology DOI: 10.1016/J.CRYOBIOL.2013.05.010
Decreased Expression of CD9 in Bovine Oocytes After Cryopreservation and the Relationship to Fertilization Capacity Authors (8): Zhou, Guang-Bin#*; Zeng, Yan#... Hou, Yun-Peng* Published: Jun 2013in Molecular Reproduction & Development DOI: 10.1002/MRD.22181
Improved parthenogenetic development of vitrified-warmed bovine oocytes activated with 9% ethanol plus 6-DMAP Authors (9): Hou, Y. -P.; Liu, Y. ... Zhu, S. -E. Published: Sep 2009in Theriogenology DOI: 10.1016/J.THERIOGENOLOGY.2009.04.020
Bovine oocytes vitrified by the open pulled straw method and used for somatic cell cloning supported development to term Authors (12): Hou, YP; Dai, YP ... Li, N Published: Oct 2005in Theriogenology DOI: 10.1016/J.THERIOGENOLOGY.2005.03.012
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