Podmore, Ian - University of Salford - Biomedical Research Centre

个人简介

I joined the University of Salford in 2001 as a lecturer in Analytical Chemistry, having previously been a Post-Doctoral Research Associate for 7 years at the University of Leicester. Overall, I have spent 27 years in research mainly involving the measurement and detection of free radicals or free radical damage in biological systems. During the period 2007-2011, I was programme leader for the MSc in Analytical Bioscience & Drug Design and in 2008 I was promoted to Senior Lecturer in Analytical Bioscience. My current roles and responsibilities include programme lead for a number of programmes within the Biomedicine discipline group, teaching at all levels of the programmes and supervision of two PhD students.

研究领域

My current research interests are focused upon the development of analytical methods (mainly based upon chromatography and mass spectrometry techniques such as GC-MS, LC-MS and MALDI-TOF) to measure biomarkers of disease, in particular those associated with free radical damage. In recent studies, we have used MALDI-TOF MS and GC-MS to detect and identify hydroxyl free radicals that have been trapped using nitrone derivatives. Future studies will focus upon expanding this work to develop a rapid assay for measuring free radicals.

近期论文

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Podmore, I., Cunliffe, L., Heshmati, M. (2013). Rapid detection of free radicals using MALDI-TOF mass spectrometry. Journal of Chemical Research, 37, p45-47. Najim, N., Podmore, I., McGown, A., Estlin, E. (2009). Methionine restriction reduces the chemosensitivity of central nervous system tumour cell lines. Anticancer Research, 29(8), p3101-3108. Najim, N., Podmore, I., McGown, A., Estlin, E. (2009). Biochemical changes and cytotoxicity associated with methionine depletion in paediatric central nervous system tumour cell lines. Anticancer Research, 29(8), p2971-2976. Mistry, P., Nigar, N., Purdie, A., Podmore, I., (2008). Indirect detection of hydroxyl radicals using spin trapping and gas chromatography-mass spectrometry, Journal of Chemical Research p395-397. Bevan R.J., Durand M.F., Hickenbotham P.T., et al. (2003). Validation of a novel ELISA for measurement of MDA-LDL in human plasma. Free Radical Biology and Medicine 35, 517. Cooke M.S., Podmore I.D., Mistry N., et al. (2003).Immunochemical detection of UV-induced DNA damage and repair. Journal of Immunological Methods 280, p125.