Hide, Geoff - University of Salford - Biomedical Research Centre

个人简介

I was educated at Edinburgh University gaining a BSc in Biological Sciences with Honours in Genetics and went on to study for a PhD in the Institute of Animal Genetics at Edinburgh with Professor Andy Tait. Here I became interested in molecular approaches to the epidemiology of parasites. I went on to do postdoctoral research at the Wellcome Unit (now Centre) of Molecular Parasitology at the University of Glasgow to work on both molecular epidemiology and cell signaling in parasites. I was appointed Lecturer, University of Salford in 1998, Reader in 2001 and Professor in August 2004 where I have been able to develop an exciting research portfolio. Over this time I have held several posts in the leadership of research at the University of Salford including Director of the Centre of Parasitology and Disease, 2000 -2007, Director Biomedical Research Institute, 2006 - 2009, Member of the University Management Group and Senate, 2006-2010, and Associate head of School (Research), 2006- 2011. I am on the Editorial Boards of a number of journals including: "Parasitology" (2003 onwards), "Parasites and Vectors" (2008 onwards ), "Clinical Epidemiology" (2008 onwards). I am a keen scuba diver and a BSAC National Instructor and First Class Diver. In 2008 I was awarded the BSAC Scubapro Cousteau Award. I am author of "The Expedition Manual" (BSAC, 2010) and a BSAC Council Member and Director. In 2014, I was awarded “Best Teacher” in the Student Led Teaching Awards 2014 run by the University of Salford Student’s Union.

研究领域

My main research interests are in molecular epidemiology of parasites where I have major projects including a long term interest in trypanosomes .In this research, we have developed molecular tools for tracking trypanosomes and shown the importance of cattle reservoir hosts on the generation of human sleeping sickness epidemics. More recently we have been developing and evaluating tools for determining prevalences of trypanosomiasis in African cattle. My current projects in this area based around developing a detailed understanding of mobile genetic elements as tools for epidemiology and on using molecular approaches to investigate host-parasite interactions in relation to the health of African cattle. I conduct this work in collaboration with scientists at the University of Edinburgh. Another principal area of my research has been to investigate the role of vertical transmission as a means by which the parasite Toxoplasma gondii is spread. This parasite is a parasite specifically of the cat but is highly successful. It infects all warm blooded animals, including infecting some 30% of the human population globally! My interest is in understanding how this parasite can be so successful. We have been principally interested in the role of mother to offspring (congenital/vertical transmission) as a mode of parasite spread. We have undertaken studies in mice and demonstrated frequent vertical transmission in natural populations. One of the key effects of this parasite is in causing abortion in domestic animals and miscarriage in humans. Our studies over a number of years have shown that vertical transmission in sheep may be very high and the impact of this is that our sheep husbandry practices maybe increasing the spread of this economically important parasite. We have ongoing studies investigating this same question in humans through collaborations with hospitals in Manchester and Libya. I have other ongoing projects which are focused around the epidemiology of Toxoplasma, the related parasite Neospora and other parasites in natural populations such as woodmice, rabbits, rats, british bats and urban pests. As part of this, I was included in a Salford team that discovered a new species of parasite, Notocotylus malhamensis. Recently, I have developed research collaborations with Professor Zhao-Rong Lun in Sun Yat-Sen University in Guangzhou in China. We are interested in the cellular mechanisms that determine the virulence of Toxoplasma gondii in mammalian hosts. We have recently published some exciting research that shows that the balance of expression of two enzymes, Arginase 1 (Arg) and inducible Nitric Oxide Synthase (iNOS), can determine virulence. We have shown that in mice, a species highly susceptible to Toxoplasma infection, have high Arg and low iNOS levels, while rats, that are resistant to the parasite, have low Arg and high iNOS. As part of this collaboration, we have also been collating data on the prevalence of the parasite in China and we recently published on infection prevalence in pregnant women in China.

近期论文

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Gao, XJ, Zhao, JZ, He, ZH, Wang, T, Yang, TB, Chen XG, Shen, JL, Wang, Y, Lu, FL, Hide, G, Lun, ZR (2012). Toxoplasma gondii infection in pregnant women in China. Parasitology, 139, 139-147. Li Z, Zhao,Z-J, Zhu X-Q, Ren Q-S, Nie F-F, Gao J-M, Gao X-J, Yang T-B, Zhou W-L, Shen J-L, Wang Y, Lu F-L, Chen X-G, Hide G, Ayala F-J, Lun Z-R. (2012). Differences in iNOS and arginase expression and activity in the macrophages of rats are responsible for the resistance against T. gondii infection. PLOS One, 7, e35834. Boyce, K, Hide, G, Craig, PS, Harris, PD, Reynolds, C, Pickles, A and Rogan, MT. (2012). Identification of a new species of digenean Notocotylus malhamensis n. sp. (Digenea: Notocotylidae) from the bank vole (Myodes glareolus) and the field vole (Microtus agrestis). Parasitology, 139, 1630-1639 Y. Chen, T. Wen, D.-H. Lai, Y.-Z. Wen, Z.-D. Wu, T.-B. Yang, X.-B. Yu, G. Hide, Z.-R. Lun (2013). Development and evaluation of loop-mediated isothermal amplification (LAMP) for rapid detection of Clonorchis sinensis from its first intermediate hosts, freshwater snails. Parasitology 140: 1377-1383. Zhao, Z, Zhang, J, Wei, J, Li, Z, Wang, T, Yi, S, Shen, J, Yang, T., Hide, G & Lun, Z (2013), 'Lower Expression of Inducible Nitric Oxide Synthase and Higher Expression of Arginase in Rat Alveolar Macrophages Are Linked to Their Susceptibility to Toxoplasma gondii Infection', PLOS One, 8, pp.e63650 Boyce, K, Hide, G. Craig, P. Reynolds, C. Hussain, M. Bodell, A. Bradshaw, H. Pickles, A & Rogan, M (2014), 'A molecular and ecological analysis of the trematode Plagiorchis elegans in the wood mouse Apodemus sylvaticus from a periaquatic ecosystem in the UK ', Journal of Helminthology, 88: 310-320.