Di Leva, Gianpiero - University of Salford - Biomedical Research Centre

个人简介

I started my research training as an undergraduate student in Italy at the University of Rome “La Sapienza”, where I worked as volunteer for two years in Dr. Bozzoni laboratory learning about RNA and its multiple functions and extraordinary plasticity. I graduated cum laude in 2004 and with the support of the Italia-USA Program Fellowship, I moved to USA to join Dr. Croce laboratory where I completed in 2009 my PhD, based both at University of Ferrara and Ohio State University., In Dr. Carlo M. Croce’s laboratory, I had the opportunity to see how simple biomolecular ideas and experimental approaches can acquire a therapeutic dimension and a bedside perspective. During this time, I acquired an interest in the role of small non-coding RNAs and their involvement in cancer by showing how they reprogramme gene expression to confer proliferative advantage to cancer cells and induce resistance to therapeutic agents. In 2014, I decided to move with my family to Manchester where I joined Dr. Richard Marais group at CRUK-Manchester Institute and had the opportunity to work in drug discovery for the development of new drugs targeting cancer stem cells. Last December, I started my position at Salford as Lecturer in Biomedical Sciences. I will focus on my long-standing interest in exploring the molecular roles of non-coding RNAs in determining cell fate changes and gene regulation. I really believe that discovering how non-coding RNAs regulate gene expression will improve our understanding of development and disease and it will allow the development of novel therapeutic strategies

研究领域

Non-coding RNAs, Cancer, Hypoxia,

近期论文

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Drusco A, Nuovo GJ, Zanesi N, Di Leva G, Pichiorri F, Volinia S, Fernandez C, Antenucci A,Costinean S, Bottoni A, Rosito IA, Liu CG, Burch A, Acunzo M, Pekarsky Y, Alder H, CiardiA, Croce CM, MicroRNA profiles discriminate among colon cancer metastasis. PLoS One. 2014; 9:e96670. Volinia S, Nuovo G, Drusco A, Costinean S, Abujarour R, Desponts C, Garofalo M, Baffa R, Aeqilan R, Maharry K, Sana ME, Di Leva G, Gasparini P, Dama P, Marchesini J, Galasso M, Manfrini M, Zerbinati C, Corrà F, Wise T, Wojcik SE, Previati M, Pichiorri F, Zanesi N, Alder H, Palatini J, Huebner KF, Shapiro CL, Negrini M, Vecchione A, Rosenberg AL, Croce CM, Garzon R, Pluripotent stem cell miRNAs and metastasis in invasive breast cancer. J Natl Cancer Inst. 2014; 106: pii: dju324. Folcik VA, Garofalo M, Coleman J, Donegan JJ, Rabbani E, Suster S, Nuovo A, Magro CM, Di Leva G, Nuovo GJ, Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri. Mod Pathol. 2014; 27:851-62.