Williams, Adrian - University of Reading

研究领域

Transdermal and topical drug delivery projects research formulation, bioavailability and distribution of topically applied medicaments. We have developed targeted delivery systems which release drugs in response to biological stimuli, in particular to exploit the changed physiology in many skin diseases (e.g. enzymes or pH) to trigger drug release at the specific diseased sites. Further research projects are exploring the penetration of large macromolecules into and through human skin and the use of polymeric carrier systems to retain drugs within the tissue. Other recent projects have investigated strategies to increase drug delivery to and through the skin using, for example, penetration enhancers, supersaturated systems or colloidal carriers. Skin repair projects use cellular markers to study the migration, differentiation and proliferation of skin cells and to understand the impact of oxygen treatment or infections on the wound healing process. To manage and alleviate dry skin conditions, we have synthesised, characterised, evaluated and patented a series of novel compounds which act as moisturisers and have developed these into peptides for long term efficacy. Point of care diagnostics for skin conditions have been developed using microneedle arrays, which are able to penetrate the outer barrier layer of human skin without reaching the lower pain receptors, and have been used to capture and analyse disease specific antibodies from the tissue. Nano-particulate diffusion projects develop nano-scale drug delivery systems for application to skin, but also to other biological membranes including the eye and mucosal surfaces. Current projects explore diffusion of nano-particulate systems in biological gels (such as mucus) and develop polymer-based mucoadhesive formulations to improve the residence time of drugs at biological membranes. Polymers are also used in designing and constructing ultrathin layer-by-layer deposited coatings to provide pH responsive control over drug dissolution within the GI tract.

近期论文

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Mansfield, E. D. H., de la Rosa, V. R., Kowalczyk, R. M., Grillo, I., Hoogenboom, R., Sillence, K., Hole, P., Williams, A. C. and Khutoryanskiy, V. V. (2016) Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier. Biomaterials Science. ISSN 2047-4830 doi: 10.1039/c6bm00375c Mun, E. A., Williams, A. C. and Khutoryanskiy, V. V. (2016) Adhesion of thiolated silica nanoparticles to urinary bladder mucosa: effects of PEGylation, thiol content and particle size. International Journal of Pharmaceutics, 512 (1). pp. 32-38. ISSN 0378-5173 doi: 10.1016/j.ijpharm.2016.08.026 Arezki, N. R., Williams, A. C., Cobb, A. J. A. and Brown, M. B. (2016) Design, synthesis and characterization of linear unnatural amino acids for skin moisturization. International Journal of Cosmetic Science. ISSN 1468-2494 doi: 10.1111/ics.12351 Arezki, N. R., Williams, A. C., Cobb, A. J. A. and Brown, M. B. (2016) Design, synthesis and characterisation of linear unnatural amino acids for skin moisturisation. International Journal of Cosmetic Science. ISSN 1468-2494 doi: 10.1111/ics.12351 Spillman, M. J., Shankland, K., Williams, A. C. and Cole, J. C. (2015) CDASH: a cloud-enabled program for structure solution from powder diffraction data. Journal of Applied Crystallography, 48 (6). pp. 2033-2039. ISSN 0021-8898 doi: 10.1107/S160057671502049X Ng, K. W., Lau, W. M. and Williams, A. C. (2015) Towards pain-free diagnosis of skin diseases through multiplexed microneedles: biomarker extraction and detection using a highly sensitive blotting method. Drug Delivery and Translational Research, 5 (4). pp. 387-396. ISSN 2190-393X doi: 10.1007/s13346-015-0231-5 Mansfield, E. D.H., Sillence, K., Hole, P., Williams, A. C. and Khutoryanskiy, V. V. (2015) POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers. Nanoscale, 7 (32). pp. 13671-13679. ISSN 2040-3364 doi: 10.1039/C5NR03178H