Caravan, Peter - Harvard Medical School - Massachusetts General Hospital

个人简介

Peter Caravan, PhD, is co-director of the Institute for Innovation in Imaging (I3) at Massachusetts General Hospital and an Associate Professor of Radiology at Harvard Medical School. He leads a multidisciplinary and translational molecular imaging lab (the Caravan Lab) focused on the invention of novel molecular probes and their broad applications in cardiovascular, pulmonary, renal and hepatic diseases, as well as in cancers. His research spans novel chemistry technologies from advanced MRI and PET imaging in animal models to applications in patient populations. He holds Investigational New Drug (IND) applications for a fibrin-targeted PET tracer and a collagen-targeted PET tracer that are currently being evaluated in 6 clinical trials. He has invented molecular probes specific to fibrogenesis, acidosis, inflammation and thrombosis, as well as gadolinium-free MR contrast agents. Dr. Caravan received a PhD in Inorganic Chemistry from the University of British Columbia. Following postdoctoral work at the EPFL (Switzerland), he spent 9 years at Epix Pharmaceuticals developing tissue-specific and responsive MRI contrast agents, one of which, gadofosveset, was approved by the FDA and the EMA. He co-invented EP-2104R, which was the first molecularly targeted MRI contrast agent to enter clinical trials. Since joining MGH in 2007, he has been continuously funded by the NIH.

研究领域

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albumins; contrast media; coordination complexes; fibrin; fibrosis; gadolinium; magnetic resonance imaging; manganese; organometallic compounds; pulmonary fibrogenesis; serum albumin