Widera, Darius - University of Reading

研究领域

I'm interested in adult stem cell research as well as in the influence of injury and inflammation on somatic cells (injury-induced cellular reprogramming). I want to understand how inflammatory signalling pathways (especially TNFR and TLR-mediated signalling) influence differentiation, proliferation and migration of stem cells.

近期论文

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Zeuner, M.-T., Krueger, C. L., Volk, K., Bieback, K., Cottrell, G. S., Heilemann, M. and Widera, D. (2016) Biased signalling is an essential feature of TLR4 in glioma cells. Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research, 1863 (12). pp. 3084-3095. ISSN 0167-4889 doi: 10.1016/j.bbamcr.2016.09.016 Müller, J., Greiner, J. F. W., Zeuner, M., Brotzmann, V., Schäfermann, J., Wieters, F., Widera, D., Sudhoff, H., Kaltschmidt, B. and Kaltschmidt, C. (2016) 1,8-cineol potentiates IRF3-mediated antiviral response in human stem cells and an ex vivo model of rhinosinusitis. Clinical Science. ISSN 0143-5221 doi: 10.1042/CS20160218 Widera, D., Klenke, C., Nair, D., Heidbreder, M., Malkusch, S., Sibarita, J.-B., Choquet, D., Kaltschmidt, B., Heilemann, M. and Kaltschmidt, C. (2016) Single-particle tracking uncovers dynamics of glutamate-induced retrograde transport of NF-κB p65 in living neurons. Neurophotonics, 3 (4). 041804. ISSN 2329-4248 doi: 10.1117/1.NPh.3.4.041804 Zeuner, M.-T., Patel, K., Denecke, B., Giebel, B. and Widera, D. (2016) Paracrine effects of TLR4-polarised mesenchymal stromal cells are mediated by extracellular vesicles. Journal of Translational Medicine, 14. 34. ISSN 1479-5876 doi: 10.1186/s12967-016-0794-z