Whalley, Ben - University of Reading

研究领域

Prof. Whalley is a Professor of Neuropharmacology and has worked at the Reading School of Pharmacy, University of Reading since 2005. His research interests lie in neuronal hyperexcitability states, their consequential disorders (e.g. epilepsy) and the preclinical development of new treatments for such disorders. A significant component of this research has been the development of new disease models, including the refinement of animal models of disease and the replacement of animals in medical research, with a particular focus on the application of electrophysiological techniques. Prof. Whalley's work has identified cellular mechanisms underlying the effects of anticonvulsants in clinical use or currently in clinical trials (e.g. UCB Pharmaceuticals), discovered non-psychoactive, anticonvulsant components of cannabis (GW Pharmaceuticals, Otsuka Pharmaceuticals and University of Reading Endowment Trust Fund), investigated cannabinoid effects upon appetite and feeding behaviours (Reading Endowment Trust Fund), anti-ataxic actions of phytocannabinoids (Ataxia UK) and the development of novel electrophysiological screening methods for candidate PET ligands (GE Healthcare). Two components of cannabis that were identified and characterised by Prof. Whalley are now being developed in Phase II and Phase III human clinical trials as treatments for drug-resistant paediatric epilepsies.

近期论文

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Heath, F., Newman, A., Clementi, C., Pasut, G., Lin, H., Stephens, G. J., Whalley, B. J., Osborn, H. M. I. and Greco, F. (2016) A novel PEG–haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer–drug conjugates in a non-prodrug fashion. Polymer Chemistry, 7 (47). pp. 7204-7210. ISSN 1759-9954 doi: 10.1039/c6py01418f Ugbode, C., Yuhan, H., Whalley, B., Peers, C., Rattray, M. and Dallas, M. (2016) Astrocyte transporters in Alzheimer's disease. Biochemical Journal. ISSN 1470-8728 (In Press) Abbassian, H., Whalley, B. J., Sheibani, V. and Shabani, M. (2016) Cannabinoid type 1 receptor antagonism ameliorates harmaline-induced essential tremor in rat. British Journal of Pharmacology, 173 (22). pp. 3196-3207. ISSN 1476-5381 doi: 10.1111/bph.13581 de Carvalho, C., Hoeller, A., Franco, P., Martini, A., Soares, F., Lin, K., Prediger, R., Whalley, B. and Walz, R. (2016) The cannabinoid CB2 receptor-specific agonist AM1241 increases pentylenetetrazole-induced seizure severity in Wistar rats. Epilepsy Research, 127. pp. 160-167. ISSN 0920-1211 doi: 10.1016/j.eplepsyres.2016.08.011 Abbassian, H., Esmaeili, P., Tahamtan, M., Aghaei, I., Vaziri, Z., Sheibani, V., Whalley, B. J. and Shabani, M. (2016) Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor. Physiology & Behavior, 164 (Part A). pp. 314-320. ISSN 0031-9384 doi: 10.1016/j.physbeh.2016.06.013 Bruyns-Haylett, M., Luo, J., Bruyns-Haylett, A. J. , Harris, S., Boorman, L., Milne, E., Vautrelle, N., Hayashi, Y., Whalley, B. J., Jones, M., Berwick, J., Riera, J. and Zheng, Y. (2016) The neurogenesis of P1 and N1: a concurrent EEG/LFP study. NeuroImage. ISSN 1053-8119 doi: 10.1016/j.neuroimage.2016.09.034 (In Press)