个人简介
动物医学院预防兽医学系教授、博士生导师，2020校引进“杰出人才”。1998年本科毕业于中国农业大学动物医学院兽医专业，2001年获中国农业大学预防兽医学硕士学位，2005获美国北卡罗莱纳州立大学兽医免疫学方向博士学位，博士毕业后在杜克大学人类疫苗研究所工作。2014年至2018年, “青年英才”引进到中国农业科学院哈尔滨兽医研究所，研究员，博导师，猪消化道传染病创新团队助理首席科学家。2019年，在美国西南医学中心进行交流访问。目前承担的科研任务包括国家自然科学基金项目、中国农业大学启动基金，以及国家“十三五”计划子任务等。主要研究成果以第一作者或通讯作者的文章发表于在PLos Pathogens, Journal of Virology等杂志，并获得发明专利1项。 担任Journal of Virology, Virology, Virology, Archives of Virology, Veterinary Microbiology等国际期刊的同行评审人。
近期论文
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Yin L, Chen J, Li L, Guo S, Xue M, Zhang J, Liu X, Feng L#, Liu Pinghuang #. Aminopeptidase N Expression, Not Interferon Responses, Determines the Intestinal Segmental Tropism of Porcine Deltacoronavirus. J Virol. 2020 Jul 1;94(14).
Sun M, Zhang L, Cao Y, Wang J, Yu Z, Sun X, Liu F, Li Z, Liu Pinghuang#, Su J#. Basic Amino Acid Substitution at Residue 367 of the Envelope Protein of Tembusu Virus Plays a Critical Role in Pathogenesis. J Virol. 2020 Mar 31;94(8):e02011-19.
Wang C, Shan L, Qu S, Xue M, Wang K, Fu F, Wang L, Wang Z, Feng L, Xu W#, Liu Pinghuang#. The Coronavirus PEDV Evades Type III Interferon Response Through the miR-30c-5p/SOCS1 Axis. Front Microbiol. 2020 May 22;11:1180.
Li L, Xue M, Fu F, Yin L, Feng L#, Liu Pinghuang#. IFN-Lambda 3 Mediates Antiviral Protection Against Porcine Epidemic Diarrhea Virus by Inducing a Distinct Antiviral Transcript Profile in Porcine Intestinal Epithelia. Front Immunol. 2019 Oct 17;10:2394.
Shan L, Fu F, Xue M, Zhu X, Li L, Feng L#, Liu Pinghuang#. Interferon gamma inhibits transmissible gastroenteritis virus infection mediated by an IRF1 signaling pathway. Arch Virol. 2019 Nov;164(11):2659-2669.
Liang Li, Fang Fu, Shanshan Guo, Hongfeng Wang, Xijun He, Mei Xue, Lingdan Yin, Li Feng, Pinghuang Liu#. Porcine Intestinal Enteroids: a New Model for Studying Enteric Coronavirus PEDV Infection and the Host Innate Response. J Virol. 2018，Dec 12. JVI.01682-18.
Yanlong Ma, Changlin Wang, Mei Xue, Fang Fu, Xin Zhang, Liang Li, Lingdan Yin, Wanhai Xu, Li Feng#, Pinghuang Liu#. The Coronavirus Transmissible Gastroenteritis Virus Evades the Type I Interferon Response through IRE1α-Mediated Manipulation of the MicroRNA miR-30a-5p/SOCS1/3 Axis. Journal of virology. 2018，Nov. 92 (22).
Mei Xue, Fang Fu, YL Ma, Xin Zhang, Liang Li, Li Feng# , Pinghuang Liu#. The PERK Arm of the Unfolded Protein Response Negatively Regulates Transmissible Gastroenteritis Virus Replication by Suppressing Protein Translation and Promoting Type I IFN Production. J Virol. 2018，Aug. 92 (15).
Saintedym Wills*, Kwan Ki-Hwang*, Pinghuang Liu*, S. Moses Dennison, Matthew Zirui Tay, Xiaoying Shen, Justin Pollara, Judith Lucas, Robert Parks, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapan, Jaranit Kaewkungwal, Rasmi Thomas, Jerome Kim, Nelson Michael, Merlin Robb, Mike McRaven, David Montefiori, Thomas Hope, Hua-Xin Liao, M. Moody, Guido Ferrari, Barton Haynes, S. Alam, Mattia Bonsignori, Georgia Tomaras. HIV-1 specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galcer Blocking and Phagocytosis. J Virol. 2018, Mar 14;92(7).
Shucheng Chen, Su Li, Huimin Sun, Yongfeng Li, Shengwei Ji, Kun Song, Lingkai Zhang, Yuzi Luo,Yuan Sun, Jifei Ma, Pinghuang Liu#, Hua-Ji Qiu#. Expression and characterization of a recombinant porcinized antibody against the E2 protein of classical swine fever virus. Applied Microbiology and Biotechnology.2017 Nov 28,
Fang Fu, Lin Li, Lingling Shan, Beibei Yang, Hongyan Shi, Jiaoer Zhang, Hongfeng Wang, Li Feng#, Pinghuang Liu#. A Spike-specific Whole-porcine Antibody Isolated from a Porcine B cell That Neutralizes both Genogroup 1 and 2 PEDV strains. Vet. Microbiology. 2017 Jun; 205:99-105 .
Mei Xue*, Jing Zhao*, Lan Ying, Fang Fu, Lin Li, Yanlong Ma , Hongyan Shi , Jiaoer Zhang, Li Feng#, Pinghuang Liu# . IL-22 Suppresses the Infection of Porcine Enteric Coronaviruses and Rotavirus by activating STAT3 signal pathway. Antiviral Research. 2017 Jun; 142:68-75.
Lin Li*, Fang Fu*, Mei Xue, Weiye Chen, Jin Liu, Hongyan Shi, Jianfei Chen, Zhigao Bu, Li Feng#, Pinghuang Liu#. IFN-lambda Preferably Inhibits PEDV Infection of Porcine Intestinal Epithelial Cells Compared with IFN-alpha. Antiviral Research. 2017 Apr.140:76-82.
Tay MZ#, Liu PH#, Williams LD#, McRaven MD, Sawant S, Gurley TC, Xu TT, Dennison SM, Liao HX, Chenine AL, Alam SM, Moody MA, Hope TJ, Haynes BF, Tomaras GD*. Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses. PLOS Pathogens .2016. 12:e1005817. (Tay MZ, Liu PH, Williams LD are contributing equally)
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