Strohfeldt -Venables, Katja - University of Reading

研究领域

Metal-based Anti-cancer Drugs This aspect of my research is based on the synthesis, analysis and biological testing of metal-based anti-cancer drugs. The search for effective anti-cancer drugs is still a very important task in modern research, especially in chemistry, as a result of the wide variety of tumor types and problems of toxicity associated with conventional cancer therapies. Metals of interest for incorporation within organometallic anti-cancer agents are germanium and titanium. The advantage of organogermanium compounds is that they combine cytotoxic activity with a stimulation of the immune system with almost no detectable sign of toxicity. Research in the area of titanium-based complexes as potential anti-cancer drugs showed impressive results over the last 5 years and we believe there is still scope for further improvements. The idea of this research area is to devise and evaluate new organic and organometallic synthetic routes to allow access to biologically interesting anti-cancer agents. Traditional Chinese Medicine (TCM) Quality Assessment Traditional Chinese Medicine refers to a range of medical concepts developed in China and based of tradition more than 2000 years ago. It includes herbal medicine, acupuncture, massage and exercise. Unfortunately, there are some herbal TCM products on the UK market that may be of questionable quality, which may impose a risk to the public. These products may be adulterated with toxic or illegal ingredients or simply produced to a low standard. It may be very difficult to distinguish between those products posing a health risk to the public and herbal TCM products made to an acceptable quality standard. Currently we are working in collaboration with the MHRA in order to develop analytical standards to identify TCM herbs of acceptable quality. Within the same project we are developing Monographs for the British Pharmacopeia to ensure quality standards being introduced in the commercial market.

近期论文

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Strohfeldt, K. and Khutoryanskaya, O. (2015) Using problem-based learning in a chemistry practical class for pharmacy students and engaging them with feedback. American Journal of Pharmaceutical Education, 79 (9). 141. ISSN 1553-6467 doi: 10.5688/ajpe799141 Sarsam, S. W., Nutt, D. R., Strohfeldt, K. and Watson, K. A. (2011) Titanocene anticancer complexes and their binding mode of action to human serum albumin: a computational study. Metallomics, 3 (2). pp. 152-161. ISSN 1756-5901 doi: 10.1039/c0mt00041h Bauer, J., Stiller, J., Marques-Lopez, E., Strohfeldt, K. A., Christmann, M. and Strohmann , C. (2010) Silyl-Modified Analogues of 2-Tritylpyrrolidine: Synthesis and Applications in Asymmetric Organocatalysis. Chemistry - A European Journal, 16 (42). pp. 12553-12558. ISSN 0947-6539 doi: 10.1002/chem.201002166 Strohfeldt, K. and Grant, D. T. (2010) A model for self-directed problem-based learning for renal therapeutics. American Journal of Pharmaceutical Education , 74 (9). Article 173. Vessieres, A., Plamont, M.-A., Cabestaing, C., Claffey, J., Dieckmann, S., Hogan, M., Mueller-Bunz, H., Strohfeldt, K. A. and Tacke, M. (2009) Proliferative and anti-proliferative effects of titanium- and iron-based metallocene anti-cancer drugs. Journal of Organometallic Chemistry , 694 (6). pp. 874-879. ISSN 0022-328X doi: 10.1016/j.jorganchem.2008.11.071