Lau, Wing-Man - University of Reading

研究领域

Transdermal and topical drug delivery: Delivery of drugs via the skin is advantageous because it avoids first-pass metabolism and minimises systemic side effects. However, the outer skin barrier prevents effective drug uptake. The focus of this work is on the use of sophisticated drug design and delivery systems (e.g. pro-drugs/co-drugs; biologically/mechanically triggered, site-specific drug release from polymers) to overcome the outer skin barrier. Drug toxicity testing: Our work focuses on the impact of the drug system at the cellular level using a range of tissue culture and molecular biology techniques including immunocytochemistry, flow cytometry and Western Blot analysis. The ultimate aim is to improve drug formulation, bioavailability, safety and patient acceptability. Wound healing: In this work, we study the cellular effects of different wound healing treatments (including hyperbaric oxygen therapy) using monolayer cell cultures and to understand the cellular mechanisms underpinning the wound healing process. Other research interests are: Clinical practice research: This work involves promoting the effective use of drugs in the primary and secondary care settings, by enhancing the roles of various healthcare professionals in patient education. This is done by identifying the current barriers to effective drug use and raising public awareness on avoiding adverse effects and improving dosing accuracy. Pharmacy Education: I also have interest in the use of technology in pharmacy education, investigating the benefit of various teaching methods and their impact in enhancing teaching and learning environment.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Filippov, S. K., Bogomolova, A. , Kaberov, L. , Velychkivska, N., Starovoytova, L., Cernochova, Z., Rogers, S. E., Lau, W. M., Khutoryanskiy, V. V. and Cook, M. T. (2016) Internal nanoparticle structure of temperature-responsive self-assembled PNIPAM-b-PEG-b-PNIPAM triblock copolymers in aqueous solutions: NMR, SANS and light scattering studies. Langmuir, 32 (21). pp. 5314-5323. ISSN 1520-5827 doi: 10.1021/acs.langmuir.6b00284 Khateb, K. A., Ozhmukhametova, E. K., Mussin, M. N., Seilkhanov, S. K., Rakhypbekov, T. K., Lau, W. M. and Khutoryanskiy, V. V. (2016) In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery. International Journal of Pharmaceutics, 502 (1-2). pp. 70-79. ISSN 0378-5173 doi: 10.1016/j.ijpharm.2016.02.027 Ng, K. W., Lau, W. M. and Williams, A. C. (2015) Towards pain-free diagnosis of skin diseases through multiplexed microneedles: biomarker extraction and detection using a highly sensitive blotting method. Drug Delivery and Translational Research, 5 (4). pp. 387-396. ISSN 2190-393X doi: 10.1007/s13346-015-0231-5 Lau, W. M., Heard, C. M. and White, A. W. (2013) Design, synthesis and in vitro degradation of a novel co-drug for the treatment of psoriasis. Pharmaceutics, 5 (2). pp. 232-245. ISSN 1999-4923 doi: 10.3390/pharmaceutics5020232 Lau, W. M., Ng, K. W., Sakenyte, K. and Charles, M. H. (2012) Distribution of esterase activity in porcine ear skin, and the effects of freezing and heat separation. International Journal of Pharmaceutics, 433 (1-2). pp. 10-15. ISSN 0378-5173 doi: 10.1016/j.ijpharm.2012.04.079 Lau, W. M., Ng, K. W., White, A. W. and Heard, C. M. (2011) Therapeutic and cytotoxic effects of the novel antipsoriasis codrug, naproxyl-dithranol, on HaCaT cells. Molecular Pharmaceutics, 8 (6). pp. 2398-2407. ISSN 1543-8392 doi: 10.1021/mp200327k