个人简介
主要从事生物催化与合成生物学、产学研相关的工作。针对传统植物提取方式存在资源匮乏、耕地依赖、周期长等问题,研究工作围绕植物天然产物及其衍生物的生物全合成、生物改性和工业化应用,建立合成植物天然产物微生物细胞工厂,发展代谢途径组装的高效工具,创建微生物合成植物天然产物的高效平台。目前主持并参与国家自然科学基金、国家863项目、企业横向课题和科技部重点研发计划等项目,发表SCI论文28篇,授权专利6项。
教育背景
2009.09-2015.07 北京理工大学,生物化工专业,工学博士
2006.09-2009.07 石河子大学,农产品加工及贮藏专业,工学硕士
2002.09-2006.07 北京理工大学,生物工程专业,工学学士
工作履历
2018.09-至今 北京理工大学化学与化工学院,预聘副教授
2015.10-2018.09 北京理工大学,化学,博士后
研究成果
承担项目
国家重点研发计划“绿色生物制造”重点专项,2021YFC2102800,可规模化应用的新型工业酶固定化技术,100万,2022/01-2024/12, 子课题负责人
国家重点研发计划“合成生物学”重点专项,2018YFA0901800,合成植物天然产物的微生物细胞工厂构建及应用示范,131万,2019/07-2024/06,子课题负责人
国家自然科学基金青年科学基金项目,21606019,β-葡萄糖醛酸苷酶水解与合成特性的转换机制,2017/01-2019/12,20万元,主持
企事业单位横向课题,生物制备甘草次酸和GAMG的中试研发,2016/10-2021/10, 500万元,主持
国家自然科学基金重点项目,21736002,微生物合成萜烯化合物过程中的跨膜转运与代谢传质强化,2019/01-2022/12, 320万元,参与
新疆自治区科学技术厅项目,生物酶法制备甘草次酸及其衍生物产品及其产业化,2017/1-2019/12,10万元,主持
北京理工大学青年教师学术启动项目,氧化鲨烯环化酶催化合成三萜骨架多样性的分子机制,2019/1-2021/12,60万元,主持
研究成果
主持国家自然科学基金项目1项、承担企业横向合作项目2项;参与国家自然科学基金项目等3项,承担国家重点研发计划“绿色生物制造”重点专项,国家重点研发计划“合成生物学”重点专项2项。迄今在国内外学术刊物及会议上发表学术论文40篇,授权专利5项。
研究领域
酶分子理性设计、分子进化、结构解析与催化机理研究
甘草次酸、薯蓣皂素、松果菊苷等高附加值植物源天然产物的生物全合成,植物天然产物细胞工厂构建
功能性微生物基因组学、转录组学等生物信息学分析
近期论文
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Sun Jiachen, Sun Wentao, Zhang Genlin*, Lv Bo*, Li Chun*. High efficient production of plant flavonoids by microbial cell factories: Challenges and opportunities. Metabolic Engineering. 2022, 70, 143-154.
Zhang Teng, Sun Yi, Ma, Zhidong, Zhang Jinwen, Lv Bo*, Li Chun*. Developing iterative and quantified transgenic manipulations of non-conventional filamentous fungus Talaromyces pinophilus Li-93. Biochemical Engineering Journal. 2022, 179, 108317.
Xu Ke, Zhao Yujia, Ahmad, Nadeem, Wang, Jinnan, Lv Bo*, Li Chun*. O-glycosyltransferases from homo sapiens contributes to the biosynthesis of glycyrrhetic acid 3-o-mono-β-d-glucuronide and glycyrrhizin in saccharomyces cerevisiae. Synthetic and Systems Biotechnology, 2021, 6(3), 173-179.
Chen L, Pang Y, Luo Y,Cheng X, Lv B*, Li C*, Separation and purification of plant terpenoids from biotransformation. Eng Life Sci. 2021;1-15.
Haoran Liu, Nadeem Ahmad, Bo Lv*, Chun Li*. Advances in production and structural derivatization of the promising molecule ursolic acid [J]. Biotechnology Journal. 2021,16(11).
Liu Mingzhu, Yu Jing, Lv Bo*, Hou Yuhui, Liu Xinhe, Feng Xudong*, & Li Chun. Improving the activity and thermostability of GH2 β‐glucuronidases via domain reassembly. Biotechnology and Bioengineering. 2021, 118(5): 1962-1972.
Jalees ul Hassan, Imdaad Kaleem , Aamir Rasool , Xu Ke, Rana Adnan Tahir,Lv Bo*, Li Chun*. Engineered Saccharomyces cerevisiae for the De Novo Synthesis of the Aroma Compound Longifolene [J]. Chemical Engineering Science, 2020: 115799.
Zhang Teng, Liu Hu, Lv Bo*, Li Chun*. Regulating strategies for producing carbohydrate active enzymes by filamentous fungal cell factories[J]. Frontiers in Bioengineering and Biotechnology, 2020, 8.
Lv Bo#, Sun Hanli#, Huang Shen, Feng Xudong, Jiang Tao, Li Chun*. Structure-guided engineering of the substrate specificity of a fungal β-glucuronidase toward triterpenoid saponins. Journal of Biological Chemistry,2018, 293(2), 433-443.
Liu xiaochen, Zhang Liang, Feng Xudong, Lv Bo*, Li Chun. Biosynthesis of Glycyrrhetinic Acid-3-O-monoglucose Using Glycosyltransferase UGT73C11 from Barbarea vulgaris[J]. Industrial & Engineering Chemistry Research, 2017, 56(51): 14949-14958.
Xu Ke, Yu Liping, Bai Wenxin, Xiao Bing, Liu Yueqin, Lv Bo*, Li Jun* , Li Chun. Construction of thermo-tolerant yeast based on an artificial protein quality control system (APQC) to improve the production of bio-ethanol. Chemical Engineering Science, 2018, 177: 410-416.
Zhang Teng, Liu Hu, Lv Bo*, Li Chun*. Regulating strategies for producing carbohydrate active enzymes by filamentous fungal cell factories[J]. Frontiers in Bioengineering and Biotechnology, 2020, 8.
Xu Ke#, Lv Bo#, Huo Yi-Xin*, Li Chun*. Toward the lowest energy consumption and emission in biofuel production: combination of ideal reactors and robust hosts. Current Opinion in Biotechnology, 2018, 50: 19-24.
Sun, Wentao, Xue Haijie, liu Hu, Lv Bo, Yu Yang, Wang Ying, Li Chun. Controlling Chemo- and Regio-selectivity of a plant P450 in yeast cell towards rare licorice triterpenoids biosynthesis. ACS Catalysis. 2020 doi:10.1021/acscatal.0c00128
Liu Hu, Cao Mingming, Wang Ying, Lv Bo, & Li Chun. Bioengineering oligomerization and monomerization of enzymes: learning from natural evolution to matching the demands for industrial applications. Critical Reviews in Biotechnology, 2020:1-16.
Xu Yinghua, Feng Xudong, Jia Jintong, Chen Xinyi, Jiang Tian, Rasool Aamir, Lv Bo, Qu Liangti, Li Chun*. A Novel β-Glucuronidase from Talaromyces pinophilus Li-93 Precisely Hydrolyzes Glycyrrhizin into Glycyrrhetinic Acid 3-O-Mono-β-d-Glucuronide. Applied and Environmental Microbiology, 2018,84(19):00755-18