Green, Rebecca - University of Reading

研究领域

Rebecca's scientific interests lie in the study of protein behaviour, and in linking their structural features to functional properties. Most recently, her research has focused on the lipid (cell membrane) binding behaviour of antimicrobial and anticancer peptides and proteins. Within the area of food security, Rebecca's recent research has focused on seed defence proteins and peptides, particularly the functional properties of puroindolines and purothionins. These proteins also have potential, with antifungal and antimicrobial activity, pharmaceutically. From the point of view of lipid biophysics, her research has focused on defining the role of different lipid constituents within biological membranes and how these provide potential binding sites for polymers, peptides and proteins. Rebecca also has broader research interests in the areas of biomaterials and biophysical chemistry, and works on a number of related projects, including protein-polyphenol interactions, formulation solutions for poorly-water soluble drugs and polymer binding to lipid surfaces in advanced drug delivery. Her research regularly utilises STFC and other central facilities; neutron (ISIS, ILL) and X-ray (Diamond) reflectivity and scattering methods.

近期论文

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Sanders, M. R., Clifton, L. A., Frazier, R. A. and Green, R. J. (2016) The role of lipid composition on the interaction between a tryptophan-rich protein and model bacterial membranes. Langmuir, 38 (8). pp. 2050-2057. ISSN 0743-7463 doi: 10.1021/acs.langmuir.5b04628 Karonen, M., Oraviita, M., Mueller-Harvey, I., Salminen, J.-P. and Green, R. J. (2015) Binding of an oligomeric ellagitannin series to bovine serum albumin (BSA): analysis by isothermal titration calorimetry (ITC). Journal of Agricultural and Food Chemistry, 63 (49). pp. 10647-10654. ISSN 0021-8561 doi: 10.1021/acs.jafc.5b04843 Albarkah, Y. R., Green, R. J. and Khutoryanskiy, V. V. (2015) Probing the mucoadhesive interactions between porcine gastric mucin and some water-soluble polymers. Macromolecular Bioscience, 15 (11). pp. 1546-1553. ISSN 1616-5187 doi: 10.1002/mabi.201500158 Ravishankar, D., Watson, K. A., Boateng, S. Y., Green, R. J., Greco, F. and Osborn, H. M.I. (2015) Exploring quercetin and luteolin derivatives as antiangiogenic agents. European Journal of Medicinal Chemistry, 97. pp. 259-274. ISSN 0223-5234 doi: 10.1016/j.ejmech.2015.04.056 Dobreva, M., Green, R.J., Mueller-Harvey, I., Salminen, J.-P., Howlin, B.J. and Frazier, R. (2014) Size and molecular flexibility affect the binding of ellagitannins to bovine serum albumin. Journal of Agricultural and Food Chemistry, 62 (37). pp. 9186-9194. ISSN 0021-8561 doi: 10.1021/jf502174r