Edwards, Alexander - University of Reading

研究领域

With a background in fundamental immunology combined with expertise in biochemical engineering, I am an interdisciplinary researcher focussed on solving current and future healthcare challenges using an engineering science approach that combines a range of fields from biology, biochemistry, chemistry and physics. I work at the interface between academic technology discovery and industrial development and have experience of both fundamental research and the commercialisation of new technology. The two main challenges I currently work on are the development of affordable microfluidics for clinical diagnostics and microbiology, and the engineering science of complex biologic therapeutics such as vaccines.

近期论文

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Reis, N. M., Pivetal, J., Loo-Zazueta, A. L., Barros, J. M. S. and Edwards, A. D. (2016) Lab on a stick: multi-analyte cellular assays in a microfluidic dipstick. Lab on a Chip, 16 (15). pp. 2891-2899. ISSN 1473-0189 doi: 10.1039/C6LC00332J de Barros, J. M.S., Costabile, A., Charalampopoulos, D., Khutoryanskiy, V. V. and Edwards, A. D. (2016) Evaluating and optimizing oral formulations of live bacterial vaccines using a gastro-small intestine model. European Journal of Pharmaceutics and Biopharmaceutics, 102. pp. 115-122. ISSN 0939-6411 doi: 10.1016/j.ejpb.2016.03.010 Loughborough University (2016) Capillary assay device with internal hydrophilic coating. WO2016012778. doi: WO2016012778 de Barros, J. M.S., Lechner, T., Charalampopoulos, D., Khutoryanskiy, V. V. and Edwards, A. D. (2015) Enteric coated spheres produced by extrusion/spheronization provide effective gastric protection and efficient release of live therapeutic bacteria. International Journal of Pharmaceutics, 493 (1-2). pp. 483-494. ISSN 0378-5173 doi: 10.1016/j.ijpharm.2015.06.051 Barbosa, A. I., Gehlot, P., Sidapra, K., Edwards, A. D. and Reis, N. M. (2015) Portable smartphone quantitation of prostate specific antigen (PSA) in a fluoropolymer microfluidic device. Biosensors and Bioelectronics, 70. pp. 5-14. ISSN 0956-5663 doi: 10.1016/j.bios.2015.03.006 Castanheira, A. P., Barbosa, A. I., Edwards, A. D. and Reis, N. M. (2015) Multiplexed femtomolar quantitation of human cytokines in a fluoropolymer microcapillary film. Analyst, 140 (16). pp. 5609-5618. ISSN 0003-2654 doi: 10.1039/C5AN00238A Gadd, A. J. R., Greco, F., Cobb, A. J. A. and Edwards, A. D. (2015) Targeted activation of toll-like receptors: conjugation of a toll-like receptor 7 agonist to a monoclonal antibody maintains antigen binding and specificity. Bioconjugate Chemistry, 26 (8). pp. 1743-1752. ISSN 1043-1802 doi: 10.1021/acs.bioconjchem.5b00302