Dallas, Mark - University of Reading

研究领域

Neurodegenerative diseases include a number of disorders that have different symptoms and effects, all of which act through the mechanism of compromising the brain's capacity to control itself or the body by damaging cells known as neurons that facilitate normal brain function. Various cellular proteins are involved in regulating normal physiological function including ion channels and neurotransmitter transporters. These complex proteins are expressed in various cell types within the central nervous system and are influenced by a host of endogenous and exogenous signalling molecules. Active research into these proteins is important as they underlie a host of pathological conditions, including neurodegenerative diseases. My research primarily uses electrophysiological techniques coupled with molecular biology experiments to further our understanding of ion channel and transporter physiology within the central nervous system. One family of transporter proteins that I am currently interested in is the glutamate transporters expressed in both neurones and astrocytes. It is widely reported that the astrocytes specific transporters become dysfunctional in neurological disorders, so by understanding more about how they are regulated, I aim to unravel new therapeutic targets for a host of neurodegenerative diseases. Current research focuses on the astrocyte transporters and how their activity is regulated by oxidative and nitrosative stress, both implicated in Alzheimer's disease pathogenesis. As part of my research into Alzheimer's disease I am a member of the Oxford Alzheimer's Research UK network I am also interested in the so called gasotransmitters and their actions as key signalling molecules in both the cardiovascular and nervous systems. These molecules (nitric oxide, carbon monoxide and hydrogen sulfide) are generated throughout the body and can either be toxic or protective to cells. A growing body of evidence suggests that these gasotransmitters regulate cellular signalling cascades by targeting specific ion channels and that this can dictate toxicity vs protection. My focus here is to understand how these gasotransmitters influence a range of cellular functions and be potentially used as cardioprotective or neuroprotective agents.

近期论文

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Ugbode, C., Yuhan, H., Whalley, B., Peers, C., Rattray, M. and Dallas, M. (2016) Astrocyte transporters in Alzheimer's disease. Biochemical Journal. ISSN 1470-8728 (In Press) Hover, S., King, B., Hall, B., Loundras, E.-A., Taqi, H., Daly, J., Dallas, M., Peers, C., Schnettler, E., McKimmie, C., Kohl, A., Barr, J. N. and Mankouri, J. (2016) Modulation of potassium channels inhibits bunyavirus infection. The Journal of Biological Chemistry, 291 (7). pp. 3411-3422. ISSN 1083-351X doi: 10.1074/jbc.M115.692673 Ibeas Bih, C., Chen, T., Nunn, A. V. W., Bazelot, M., Dallas, M. and Whalley, B. J. (2015) Molecular targets of cannabidiol in neurological disorders. Neurotherapeutics, 12 (4). pp. 699-730. ISSN 1933-7213 doi: 10.1007/s13311-015-0377-3 Peers, C., Boyle, J. P., Scragg , J. L., Dallas, M., Al-Owais, M. M., Hettiarachichi , N. T., Elies, J., Johnson, E., Gamper, N. and Steele, D. (2015) Diverse mechanisms underlying the regulation of ion channels by carbon monoxide. British Journal of Pharmacology, 172 (6). pp. 1546-1556. ISSN 0007-1188 doi: 10.1111/bph.12760 Duckles, H., Boycott, H. E., Al-Owais, M. M., Elies, J., Johnson, E., Dallas, M. L., Porter, K. E., Giuntini, F., Boyle, J. P., Scragg, J. L. and Peers, C. (2015) Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels. Pflugers Archive: European Journal of Physiology, 467 (2). pp. 415-427. ISSN 1432-2013 doi: 10.1007/s00424-014-1503-5 Karttunen, S., Duffield, M., Scrimgeour, N. R., Squires, L., Lim, W. L., Dallas, M. L., Scragg, J. L., Chicher, J., Dave, K. A., Whitelaw, M. L., Peers, C., Gorman, J. J., Gleadle, J. M., Rychkov, G. Y. and Peet, D. J. (2015) Oxygen-dependent hydroxylation by Factor Inhibiting HIF (FIH) regulates the TRPV3 ion channel. Journal of Cell Science, 128 (2). pp. 225-231. ISSN 0021-9533 doi: 10.1242/jcs.158451