Bithell, Angela - University of Reading

研究领域

My interests are in the molecular and cellular mechanisms that underlie normal developmental of the central nervous system (CNS) and CNS-related disorders. My research uses model systems and 'omics technologies to determine the gene regulatory networks and role of the epigenome in embryonic stem cells, neural stem cells, neurons and glia. The goal of my research group is to increasingly exploit the power of combining these tools with current bioinformatics and novel computational approaches towards a systems level understanding underpinning two central research themes: Understanding the molecular and cellular basis of neurodegenerative, neurodevelopmental and psychiatric disorders Investigating the regenerative potential of endogenous glial cell populations for adult central nervous system repair

近期论文

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Michelucci, A., Bithell, A., Burney, M. J., Johnston, C. E., Wong, K.-Y., Teng, S.-W., Desai, J., Gumbleton, N., Anderson, G., Stanton, L. W., Williams, B. P. and Buckley, N. J. (2016) The neurogenic potential of astrocytes is regulated by inflammatory signals. Molecular Neurobiology, 53 (6). pp. 3724-3739. ISSN 1559-1182 doi: 10.1007/s12035-015-9296-x Bhinge, A., Namboori, S. C., Bithell, A., Soldati, C., Buckley, N. J. and Stanton, L. W. (2016) MiR-375 is essential for human spinal motor neuron development and may be involved in motor neuron degeneration. Stem Cells, 34 (1). pp. 124-134. ISSN 1066-5099 doi: 10.1002/stem.2233 Smith, I., Haag, M., Ugbode, C., Tams, D., Rattray, M., Przyborski, S., Bithell, A. and Whalley, B. J. (2015) Neuronal-glial populations form functional networks in a biocompatible 3D scaffold. Neuroscience Letters, 609. pp. 198-202. ISSN 0304-3940 doi: 10.1016/j.neulet.2015.10.044 Soldati, C., Caramanica, P., Burney, M. J., Toselli, C., Bithell, A., Augusti-Tocco, G., Stanton, L. W., Biagioni, S., Buckley, N. J. and Cacci, E. (2015) RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro. Journal of Neuroscience Research, 93 (8). pp. 1203-1214. ISSN 1097-4547 doi: 10.1002/jnr.23572