个人简介
Education
2010-2015 PhD, Medicinal Chemistry, Peking University (advisor: Prof. Ning JIAO)
2006-2010 BS, Applied Chemistry, China Agricultural University
Professional Experience
2022- Vice Dean, Marine Biomedical Research Institute of Qingdao
2019- Professor, Ocean University of China, School of Medicine and Pharmacy
2016-2019 Postdoctoral Fellow, College of Pharmacy, University of Michigan (advisor: Prof. Shaomeng WANG)
Academic Services
Reviewer of J. Med. Chem., etc.
Honors and Awards
2019 The First Class Prize of the Beijing Science and Technology Award
2014 May 4th Medals for Students, Peking University
Projects
2022-2025 Young Scientist Project, the National Key Research and Development Program of China, hosting
2022-2024 Youth Project, National High-level Talents Program, hosting
2022-2024 Youth Fund, the National Natural Science Foundation of China, hosting
2022-2024 Excellent Young Scientists Fund, Natural Science Foundation of Shandong, hosting
2020-2024 Youth Taishan Scholar, Shandong Government, hosting
研究领域
PROTAC
Discovery and development of Proteolysis Targeting Chimera (PROTAC)-based lead compounds and drugs
CRPC
Research on therapeutic drugs for Castration-Resistant Prostate Cancer
MBS
Discovery and development of medicinal properties and improvement of druggability of
近期论文
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Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis.Zhuoyue Li+, Yiming Chen+, Xiaolin Jiang+, Penghui Lu, Chengli Wang, Zhimin Li, Xinyue Yu, Zixuan Yang, Shumin Ma, Shanshan Du, Zhengfu Tai, Xiaoyang Li*, Siqi Zhang*, Yuqi Jiang*, Chong Qin* J. Med. Chem.2023, ASAP. DOI:10.1021/acs.jmedchem.3c00894
Discovery of BWA-522, a First-in-Class and Orally Bioavailable PROTAC Degrader of the Androgen Receptor Targeting N-Terminal Domain for the Treatment of Prostate Cancer. Bowen Zhang+, Chang Liu+, Zhenqian Yang+, Sai Zhang+, Xiaolin Hu, Baohu Li, Mei Mao, Xiao Wang, Zhuoyue Li, Shumin Ma, Siqi Zhang, Chong Qin* J. Med. Chem.2023, 66, 11158
Design, Synthesis and Biological Evaluation of Androgen Receptor (AR) Antagonist-Heat Shock Protein 90 (Hsp90) Inhibitor Conjugates for Targeted Therapy of Castration-Resistant Prostate Cancer. Siqi Zhang+, Xiaolei Meng+, Sai Zhang+, Baohu Li, WencongJin, Chengwei Zhang, Zhaojuan Liu, Xiaolin Hu, Ling Ge, Zhonghao Yu, Zhuoyue Li, Shumin Ma, Xiao Wang, Liming Li, Chong Qin* J. Med. Chem.2023, 66, 4784
Inhibition of Astrocytic Carbohydrate Sulfotransferase 15 Promotes Nerve Repair After Spinal Cord Injury via Mitigation of CSPG Mediated Axonal Inhibition. Liming Li+*, Heping Zheng+, Xuepei Ma, Jie Bai, Shumin Ma, Zhuoyue Li, Chong Qin*. Cell. Mol. Neurobiol. 2023, doi: 10.1007/s10571-023-01333-9
Lethal Activity of BRD4 PROTAC Degrader QCA570 Against Bladder Cancer Cells. Qiang Wang, Baohu Li, Wenkai Zhang, Zhuoyue Li, Bo Jiang*, Sichuan Hou*, Shumin Ma*, Chong Qin* Front. Chem. 2023, 11, 1121724
PROTAC Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration. Ruxuan Wang, Tengjiang Zhong, QiongBian, Sai Zhang, Xiaolu Ma, Liming Li, Yihua Xu, Yueting Gu, Anran Yuan, Weitong Hu, Chong Qin*, Jianqing Gao* Small Methods. 2023, 7, 2201293
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. Chong Qin,+Yang Hu,+ Bing Zhou,+... Shaomeng Wang* J. Med. Chem. 2018, 61, 6685–6704
Splitting a Substrate into Three Parts: Gold-Catalyzed Nitrogenation of Alkynes by C-C and C≡C Bond Cleavage. Chong Qin+, Yijin Su+, Xiaodong Shi, Ning Jiao* Angew. Chem. Int. Ed. 2016, 55, 350-354
Highly Selective Csp2-Csp Bond Cleavage: The Nitrogenation of Alkynes to Amides. Chong Qin, Peng Feng, Yang Ou, Tao Shen, Teng Wang, Ning Jiao* Angew. Chem. Int. Ed. 2013, 52, 7850-7854
FeCl2-promoted Unactivated C-C Bond Cleavage of Alkylarenes and Polystyrene: Direct Synthesis of Versatile Arylamines. Chong Qin, Tao Shen, Conghui Tang, Ning Jiao* Angew. Chem. Int. Ed. 2012, 51, 6971-6975
Iron-catalyzed C-H and C-C Bond Cleavage: A Direct Approach to Amides from Simple Hydrocarbon Molecules. Chong Qin, Wang Zhou, Feng Chen, Yang Ou, Ning Jiao* Angew. Chem. Int. Ed. 2011, 50, 12595-12599
Iron-Facilitated Direct Oxidative C−H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles. Chong Qin, Ning Jiao* J. Am. Chem. Soc. 2010, 132, 15893-15895
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