阎锡蕴 - 北京理工大学

个人简介

2013年首届中国科学院王宽诚优秀女科学家奖（两位获奖者之一）；现任中国科学院生物物理研究所研究员，蛋白质与多肽药物重点实验室主任，中国生物物理学会副理事长兼秘书长。主持基金、项目、课题等情况传染病检测新技术，主持，国家级，2013-01--2015-12 肝炎进展为肝癌的早期诊断标志物筛选，参与，国家级，2012-01--2015-12 纳米磁性颗粒生物活性研究，参与，国家级，2011-07--2015-07 CD146作为关键节点调控非可控性炎症恶性转化分子机制研究，主持，国家级，2011-01--2013-12 教育经历 1977–1982 河南医科大学，医学学士 1983–1989 中国科学院生物物理研究所，实研，助研 1989–1993 德国海德堡大学理论医学院，博士工作经历 1994–1996 美国Memorial Sloan-Kettering癌症研究中心，博士后 1994–至今中国科学院微生物研究所研究员、中国科学院生物物理研究所研究员, 博导

研究领域

科研方向主要涉及肿瘤新靶点的发现和鉴定，纳米探针与载体药物在肿瘤诊断和治疗的应用研究。她提出纳米酶新概念（Nature Nanotechnology 2007，单篇他引1000余次），并将其应用于肿瘤诊断及治疗（Nature Nanotechnoloy 2012，PNAS 2014）的系统性研究成果获国家自然科学奖二等奖。她发表研究论文140余篇，发明专利30项，部分专利已经进入美国、欧洲和日本并实现成果转化

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Gao L, Zhuang J, Nie L, Zhang JB, Zhang Y, Gu N, Wang TH, Feng J, Yang DL, Perrett S, Yan XY. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles and application in an immunoassay. Nature Nanotechnology, 2 (9) (2007), 577-83. Fan KL, Cao CQ, Pan YX, Lu D, Yang DL, Feng J, Song LN, Liang MM & Yan XY. Magnetoferritin nanoparticles for targeting and visualizing tumor tissues. Nature Nanotechnology, 7(7) (2012), 459-64. Minmin Liang, Kelong Fan, Meng Zhou, Demin Duan, Jiyan Zheng, Dongling Yang, Jing Feng and Xiyun Yan*. H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection. Proc Natl Acad Sci U S A. 2014;111(41) ,14900-5. Zeng QQ, Li WD, Lu D, Wu ZZ, Duan HX, Luo YT, Feng J, Yang DL, Fu L and Yan XY. CD146, an epithelial-mesenchyaml transition inducer, is associated with triple-negative breast cancer. Proc. Natl. Acad. Sci. USA, 109 (4) (2012), 1127-32. Zhongde Ye, Chunxia Zhang, Tao Tu, Min Sun, Dan Liu, Di Lu, Jing Feng, Dongling Yang,Feng Liu* & Xiyun Yan*. Wnt5a uses CD146 as a receptor to regulatecell motility and convergent extension. Nature Communications. 2013;4,2803. Tao Tu, Chunxia Zhang, Huiwen Yan, Yongting Luo, Ruirui Kong, Pushuai Wen, Zhongde Ye, Jianan Chen, Jing Feng, Feng Liu, Jane Y. Wu*, Xiyun Yan*. CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. Cell Research. 2015;25(3), 275-87. Yanzhao Zhao, Minmin Liang, Xiao Li, Kelong Fan, Jie Xiao, Yanli Li, Hongcheng Shi, Fei Wang, Hak Soo Choi,* Dengfeng Cheng,* and Xiyun Yan*. Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging. ACS Nano. 2016; 10 (4), 4184–4191 Demin Duan, Kelong Fan, Dexi Zhang, ShuguangTan, Mifang Liang, Yang Liu, Jianlin Zhang, PanheZhang, Wei Liu, Xiangguo Qiu, Gary P. Kobinger,George Fu Gao, Xiyun Yan*. Nanozyme-strip for rapid local diagnosis of Ebola. Biosensors and Bioelectronic. 2015;74(5),134-141. Yan XY, Lin Y, Yang DL, Shen Y, Yuan M, Zhang ZQ, Li PY, Xia HT, Li L, Luo DD, Liu Q, Mann K, Bader BL. A novel anti-CD146 monoclonal antibody, AA98, inhibits angiogenesis and tumor growth. Blood, 102 (1) (2003), 184-91. Jiang TX, Zhuang J, Duan HX, Luo YT, Zeng QQ, Fan KL, Yan HW, Lu D, Ye ZD, Hao JF, Feng J, Yang DL, Yan XY. CD146 is a co-receptor for VEGFR-2 in tumor angiogenesis. Blood, 120 (11) (2012), 2330-9. Yongting Luo,#, Hongxia Duan,#, Yining Qian,#, Liqun Feng, Zhenzhen Wu, Jing Feng, Dongling Yang, Zhihai Qin, Xiyun Yan. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis. Cell Research, 2017 Qian Gao, Junfeng Zhang, Xiumei Wang, Ying Liu, Rongqiao He, Xingfeng Liu, Fei Wang, Jing Feng, Dongling Yang, Zhaoqing Wang, Anming Meng, and Xiyun Yan. The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. Nature Communications. 2017 Jun 7;8:15279. Jianan Chen, Yongting Luo, Hui Hui, Tanxi Cai, Hongxin Huang, Fuquan Yang, Jing Feng, Jingjing Zhang, and Xiyun Yan. CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl Acad Sci U S A. 2017 Sep 5; 114(36): E7622–E7631.