Cardin, Christine - University of Reading

研究领域

Professor Christine Cardin has been an X-ray Nature Chemistry Covercrystallographer for many years, with many longstanding collaborations. Recently she has very research active in the area of nucleic acid structure, with a focus on the precise details of small molecule interactions, including the ruthenium polypyridyl 'light-switch' and related metal complexes. The purposes of the work included an understanding of the molecular basis of the 'light switch' effect, and the development of new complexes. This work has featured on journal covers and is now funded by the BBSRC, the Royal Society, and Diamond Light Source, now also including programme access to the lasers for Science facility (CruX programme).Her current projects are strongly collaborative, being both interdisciplinary and interinstitutional. Within the University she works extensively with Dr John Brazier (School of Pharmacy), whose interest in the DNA i-motif lends itself to a range of joint initiatives

近期论文

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Hall, J. P., Keane, P. M., Beer, H., Buchner, K., Winter, G., Sorensen, T. L., Cardin, D. J., Brazier, J. A. and Cardin, C. J. (2016) Delta chirality ruthenium ‘light-switch’ complexes can bind in the minor groove of DNA with five different binding modes. Nucleic Acids Research, 44 (19). pp. 9472-9482. ISSN 1362-4962 doi: 10.1093/nar/gkw753 Keane, P. M., Baptista, F. R., Gurung, S. P., Devereux, S. J., Sazanovich , I. V., Towrie, M., Brazier, J. A., Cardin, C. J., Kelly, J. M. and Quinn, S. J. (2016) Long-lived excited-state dynamics of i-motif structures probed by time-resolved infrared spectroscopy. ChemPhysChem, 17 (9). pp. 1281-1287. ISSN 1439-7641 doi: 10.1002/cphc.201501183 Poynton, F. E., Hall, J. P., Keane, P. M., Schwarz, C., Sazanovich, I. V., Towrie, M., Gunnlaugsson, T., Cardin, C. J., Cardin, D. J., Quinn, S. J., Long, C. and Kelly, J. M. (2016) Direct observation by time-resolved infrared spectroscopy of the bright and the dark excited states of the [Ru(phen)2(dppz)]2+ light-switch compound in solution and when bound to DNA. Chemical Science. ISSN 1478-6524 doi: 10.1039/C5SC04514B Keane, P. M., Poynton, F. E., Hall, J. P., Clark, I. P., Sazanovich, I. V., Towrie, M., Gunnlaugsson, T., Quinn, S. J., Cardin, C. J. and Kelly, J. M. (2015) Monitoring guanine photo-oxidation by enantiomerically resolved Ru(II) dipyridophenazine complexes using inosine-substituted oligonucleotides. Faraday Discussions, 185. pp. 455-469. ISSN 1364-5498 doi: 10.1039/c5fd00085h Hall, J. P., Poynton, F. E., Keane, P. M., Gurung, S. P., Brazier, J. A., Cardin, D. J. , Winter, G., Gunnlaugsson, T., Sazanovich, I. V., Towrie, M., Cardin, C. J., Kelly, J. M. and Quinn, S. J. (2015) Monitoring one-electron photo-oxidation of guanine in DNA crystals using ultrafast infrared spectroscopy. Nature Chemistry, 7. pp. 961-967. ISSN 1755-4330 doi: 10.1038/nchem.2369