Harwood, Laurence - University of Reading - The Chemical Analysis Facility

研究领域

Work in the group revolves around the development of new synthetic methods and their application to the synthesis of natural and unnatural products. There are projects underway with the aims of developing synthetic approaches towards amino acids and peptides with an increasing emphasis on chemistry at the biological interface. This work has led to a spin out company TechnoPep (http://www.technopep.com/). At the same the group also has interests in the materials area, working closely with academic institutes and industrial centres throughout Europe in the area of nuclear reprocessing, developing ligands that selectively remove the minor actinides to reduce the long term nuclear legacy of stored waste. This work is also being applied to soil remediation for removal of radionucleides and heavy metals.

近期论文

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L. M. Harwood and F. W. Lewis, “Recent Applications of the Intramolecular Diels-Alder Reaction of Furan (IMDAF) Reaction in Natural Product Synthesis”, Targets in Heterocyclic Synthesis, Editors O. A. Attanasi and D. Spinelli, Italian Society of Chemistry, 2013, 16, 1 L. M. Harwood and R. J. Vickers “Ultra–High Pressure as a Mild Synthetic Tool”, New Perspectives in the Frontiers of Chemical Research, Editor S. S. Chakravorti, Golden Jubilee Commemorative Scientific Monograph, R.S.C. (E. I. S.), 2005, pp 118-141. Y. Gan, L. M. Harwood, S. C. Richards, I. E. D. Smith and V. Vinader,“Cycloadditions of chiral carbonyl ylides with imine dipolarophiles as a route to enantiomerically pure -amino--hydroxy acids”. Tetrahedron Asymmetry, 2009, 20, 723. L. M. Harwood, D. A. Wellings and D. J. Moody, “Chemical Ligation by Ring Opening of Oxo-Thiomorpholines”, February 2012, International PCT application number WO2012/020231 A1. F. W. Lewis, M. J. Hudson, L. M. Harwood, “Development of Highly Selective Ligands for Separations of Actinides from Lanthanides in the Nuclear Fuel Cycle”, Synlett, 2011, 2609.