陈增胜 - 北京航空航天大学 - 医学科学与工程学院 / 医工交叉创新研究院

个人简介

教育背景 2006.09-2012.01 北京航空航天大学生物医学工程博士学位（导师：邓小燕） 2002.09-2006.07 北京航空航天大学生物工程学士学位工作经历 2020.12-至今北京航空航天大学，医工交叉创新研究院，研究员/博导 2019.06-2020.12 北京航空航天大学，医工交叉创新研究院，副研究员/博导 2017.01-2019.04 美国马里兰大学医学院，外科系, 讲师（教职） 2015.09-2017.01 美国路易维尔大学医学院，心胸外科系, 讲师（教职） 2014.12-2015.09 美国路易维尔大学医学院，心胸外科系，博士后（合作导师：吴忠俊） 2014.03-2014.12 美国马里兰大学医学院，外科系，博士后（合作导师：吴忠俊） 2012.01-2014.03 清华大学，航天航空学院，工程力学系，博士后（合作导师：张锡文）代表性科研项目科技部“公共安全风险防控与应急技术装备”重点研发计划项目课题，ECMO 核心部件血泵、膜肺系统及插管研制，2021.02-2024.01，1716万元，在研，主持北京市科委新冠肺炎疫情科技防控项目课题，ECMO 核心部件血泵、膜肺和插管研发，2020.06-2022.12，500万，在研，主持企业合作项目，新型左心辅助血泵研制，60万，2020.10-2022.10，在研，主持北航“双一流”专项人才经费， ECMO核心部件离心血泵研发，31.5万元，2021.01-2021.12, 在研，主持北京航空航天大学“青年拔尖”人才项目，便携式人工心肺(ECMO)研发，25万元，2020.03-2021.12，在研，主持美国NIH RO1重点项目，Development and Pre-Clinical Trial Qualification of a Pediatric Pump-Lung System for Children (儿童人工心肺系统的研发和临床测试)，300万美元，2018.06-2023.06，在研，主要参与者美国NIH RO1重点项目，Shear-Induced Hemostatic Dysfunction and Bleeding in CF-VAD recipients(放置人工心脏病人中剪切力引起止血系统失调和出血并发症的机理研究)，2015.04-2019.03，198万美元，结题，主要参与者美国NIH RO1重点项目，First-In-Human Use of an Artificial Lung for Ambulatory Respiratory Support（首个用于呼吸支持的便携式人工肺的研发），2013.07-2018.03，495万美元，结题，主要参与者

研究领域

生物力学血流动力学仿真和实验研究血管支架和腔静脉滤器等值介入器械优化设计人工心脏，人工心肺，体外膜肺氧合 (ECMO) 等机械辅助循环医疗器械优化设计医疗器械血液相容性及血栓凝血机制研究医疗器械血液损伤模型建模研究医疗器械从概念到临床产品的研发

近期论文

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Zengsheng Chen, Anqiang Sun, Hongyu Wang, Yubo Fan, Xiaoyan Deng*. Non-physiological shear stress-induced blood damage in ventricular assist device. Medicine in Novel Technology and Devices. 3 2019;100024(3). Zengsheng Chen, Jiafeng Zhang, Tieluo Li, Douglas Tran, Bartley P. Griffith, Zhongjun Wu*. The impact of shear stress on device-induced platelet hemostatic dysfunction relevant to thrombosis and bleeding in mechanically assisted circulation. Artificial Organs. 2020;44(5):E201-E213. Zengsheng Chen, Douglas Tran, Tieluo Li, Katherin Arias, Bartley P. Griffith, Zhongjun J Wu*. The role of ADAM proteolysis and mechanical damage in non-physiological shear stress induced-platelet receptor shedding. ASAIO J. 2020;66(5):524-531. Zengsheng Chen, Tieluo Li, Kareem Kafayat, Xiaoyan Liu, Douglas Tran, Bartley P. Griffith, Zhongjun J. Wu*. The role of PI3K/AKT signaling pathway in Non-physiological shear stress-induced platelet activation. Artificial Organs. 2019 ;43(9):897-908. Zengsheng Chen, Jiafeng Zhang, Kareem Kafayat, Xiaoyan Liu, Douglas Tran, Gregory Conway, Bartley P. Griffith, Zhongjun J. Wu*. Device-Induced Opposite Effects on Platelet Hemostatic Function: Thrombosis and Bleeding. Artificial Organs. 2019;43(8):745-755. Zengsheng Chen, Sofen K Jena, Guruprasad A Giridharan, Michael A Sobieski, Steven C Koenig, Mark S Slaughter, Bartley P Griffith, and Zhongjun J Wu*. Shear Stress and Blood Trauma under Constant and Pulse-Modulated Speed CF-VAD Operations: CFD Analysis of the HVAD. Med Biol Eng Comput. 2019;57(4):807-818. Zengsheng Chen, Steven C Koenig, Mark S Slaughter, Bartley P. Griffith and Zhongjun J*. Wu Quantitative Characterization of Shear-Induced Platelet Receptor Shedding: Glycoprotein Ibα, Glycoprotein VI and Glycoprotein IIb/IIIa. ASAIO J. 2018;64(6):773-778. Zengsheng Chen, Mondal NK, Shirong Zheng, Steven C Koenig, Mark S Slaughter, Bartley P Griffith, and Zhongjun J Wu*. High Shear Induces Platelet Dysfunction Leading to Enhanced Thrombotic Propensity and Diminished Hemostatic Capacity. Platelets. 2019;30(1):112-119. Zengsheng Chen, Sofen K Jena, Guruprasad A Giridharan, Steven C Koenig, Mark S Slaughter, Bartley P Griffith, and Zhongjun J Wu*. Flow Features and Device-Induced Blood Trauma in CF-VADs under a pulsatile blood flow condition: A CFD Comparative Study. Int J Numer Method Biomed Eng. 2018 Feb;34(2):10.1002/cnm.2924. Zengsheng Chen, Nandan K Mondal, Jun Ding, Steven C. Koenig, Mark S. Slaughter and Zhongjun J. Wu*. Paradoxical Effect of Non-Physiological Shear Stress on Platelets and von Willebrand factor. Artificial Organs 2016 Jul;40 (7):659-68. Zengsheng Chen, Nandan K. Mondal, Jun Ding, Steven C. Koenig, Mark S. Slaughter, Bartley P. Griffith, and Zhongjun J. Wu*. Activation and shedding of platelet glycoprotein IIb/IIIa under non-physiological shear stress. Mol Cell Biochem. 2015; 409(1-2):93-101. Zengsheng Chen, Nandan K. Mondal, Jun Ding, Jingya Gao, Bartley P. Griffith and Zhongjun J. Wu*. Shear-induced platelet receptor shedding by non-physiological high shear stress with short exposure time: glycoprotein Ibα and glycoprotein VI. Thromb Res. 2015;135(4):692-8. Chen Zengsheng, Zhan F, Ding J, Zhang X, Deng X*. A new stent with streamlined cross-section can suppress monocyte cell adhesion in the flow disturbance zones of the endovascular stent. Comput Methods Biomech Biomed Engin. 2014; 1:1-7.