Gibbins, Jon - University of Reading - School of Biological Sciences

研究领域

Funding from British Heart Foundation, MRC, BBSRC, Heart Research UK, and pharmaceutical companies Programme grants from British Heart Foundation and MRC Understanding of the molecular mechanisms that regulate the function of platelets in haemostasis and thrombosis Development of new strategies for the prevent of thrombosis Cell signalling, specialist assays of haematological function, in vivo analysis of thrombosis and its prevention Development of a mathematical model of platelet signalling and function - the Virtual Platelet - for in silico experimentation, drug discovery and diagnosis. Founding director of the ICMR, which brings together the distinctive range of research expertise across the University to enable us impact on reducing the burden of cardiovascular diseases and the metabolic conditions from which they develop, through disease prevention and treatment.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Moraes, L. A., Unsworth, A. J., Vaiyapuri, S., Ali, M. S., Sasikumar, P., Sage, T., Flora, G. D., Bye, A. P., Kriek, N., Dorchies, E., Molendi-Coste, O., Dombrowicz, D., Staels, B., Bishop-Bailey, D. and Gibbins, J. M. (2016) FXR and its ligands inhibit the function of platelets. Arteriosclerosis Thrombosis and Vascular Biology, 36 (12). pp. 2324-2333. ISSN 1524-4636 doi: 10.1161/ATVBAHA.116.308093 Unsworth, A. J., Kriek, N., Bye, A. P., Naran, K., Sage, T., Flora, G. D. and Gibbins, J. M. (2016) PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signalling and platelet function through upregulation of protein kinase A activity. Journal of Thrombosis and Haemostasis. ISSN 1538-7933 doi: 10.1111/jth.13578 (In Press) Crescente, M., Pluthero , F. G., Li, L., Lo, R. W., Walsh, T. G., Schenk, M. P., Holbrook, L. M., Loureiro, S., Ali, M. S., Vaiyapuri, S., Falet, H., Jones, I. M., Poole, A. W., Kahr, W. H. A. and Gibbins, J. M. (2016) Intracellular trafficking, localization, and mobilization of platelet-borne thiol isomerases. Arteriosclerosis Thrombosis and Vascular Biology, 36 (6). pp. 1164-1173. ISSN 1079-5642 doi: 10.1161/ATVBAHA.116.307461 Bye, A. P., Unsworth, A. J. and Gibbins, J. M. (2016) Platelet signaling: a complex interplay between inhibitory and activatory networks. Journal of Thrombosis and Haemostasis, 14 (5). pp. 918-930. ISSN 1538-7933 doi: 10.1111/jth.13302 Gibbins, J. M. (2016) Platelets stop us leaking. Blood, 127 (12). pp. 1528-1529. ISSN 0006-4971 doi: 10.1182/blood-2016-01-692186