个人简介
教育背景
2006.9-2011.7 中国科学院北京基因组研究所 遗传学 博士（导师，曾长青）
2002.9-2006.7 北京航空航天大学 生物工程 学士
工作经历
2020.4-至今 北京航空航天大学 医工交叉创新研究院 副研究员
2016.1-2020.4 中国科学院北京基因组研究所 副研究员
2011.7-2015.12 中国科学院北京基因组研究所 助理研究员
代表性科研项目
国际自然科学基金青年项目，人类胚胎发育过程中体细胞突变特征、热点及组织特异性分析，2018.01-2020.12，25万元，结题，主持
国家自然科学基金重大研究计划集成项目，大规模多态信息的细胞溯祖理论和统计分析方法，2017.01-2019.12，114.6万元，结题，参加
国家自然科学基金应急管理项目，体细胞点突变在健康个体基因组中的分布模式及组织特异性研究，2015.01-2015.12，15万元，结题，主持
国家重点基础研究发展计划，近视发生相关视觉信息处理异常的遗传因素研究，2011.01-2015.12，697万元，结题，参加
研究领域
遗传学、基因组学、生物信息学。
1、分子细胞遗传学
a. 体细胞突变的发生、演进、分布特性、功能影响的系统性研究
b. 单细胞组学解析组织细胞异质性与复杂表型的关联
2、群体遗传学
a. 复杂疾病的遗传易感性
b. 人类微进化及适应性表型的遗传基础解析
近期论文
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Deng Wu#, Yunao Liu#, Wei Chen*, Jianming Shao, Pubu Zhuoma, Dexiong Zhao, Yang Yu, Tianzi Liu, Ruoxuan Yu, Yongna Gan, Baima Yuzheng, Yongshu Huang, Haikun Zhang, Xiaoman Bi, Chengcheng Tao, Shujuan Lai, Qiaoxia Luo, Dake Zhang, Hongmei Wang, Pingcuo Zhaxi, Jianqing Zhang, Jie Qiao, Changqing Zeng*, How placenta promotes the successful reproduction in high-altitude populations: a transcriptome comparison between adaptation and acclimatization, Molecular Biology and Evolution, 2022;, msac120,
Yaqiang Hong#, Dake Zhang#, Xiangtian Zhou#, Aili Chen#, Amir Abliz#, Jian Bai, Liang Wang, Qingtao Hu, Kenan Gong, Xiaonan Guan, Mengfei Liu, Xinchang Zheng, Shujuan Lai, Hongzhu Qu, Fuxin Zhao, Shuang Hao, Zhen Wu, Hong Cai, Shaoyan Hu, Yue Ma, Junting Zhang, Yang Ke, Qianfei Wang, Wei Chen*, Changqing Zeng*; Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia, Genomics, Proteomics & Bioinformatics. 2021. doi: 10.1016/j.gpb.2021.09.005
Fuxin Zhao#; Hui Zhou#; Wei Chen#; Chenchen Zhao; Yangyang Zheng; Yijin Tao; Miaozhen Pan; Peter S.Reinach; Jiadi Zhua; Jianhong An; Runxia Lu; Jiang-fan Chen; Huifang Tang; Changqing Zeng; Jia Qu; Xiangtian Zhou*; Declines in PDE4B activity promote myopia progression through downregulation of scleral collagen expression, Experimental Eye Research. 2021.11(212)
Liang Wang#; Xiaonan Guan#; Qingtao Hu#; ZhenWu#; Wei Chen#; Lairong Song; Ke Wang; Kaibing Tian; Chunwei Cao; Dake Zhang; Junpneg Ma; Xiangjun Tong; Bo Zhang; Juting Zhang*; Changqing Zeng C*; TGFB3 downregulation causing chordomagenesis and its tumor suppression role maintained by Smad7. Carcinogenesis. 2021.04(42):913-923.
Wei Chen#; Ke Zhang#; Peiling Dong#; Gregory Fanning; Chengcheng Tao; Haikun Zhang; Shicheng Guo; Zheng Wang; Yaqiang Hong; Xiaobo Yang; Shujuan Lai; Huiguo Ding; Haitao Zhao; Changqing Zeng*; Ulrike Protzer*; Dake Zhang*; Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer, Hepatology International, 2020.05 (14):326-337.
Zhenglin Du#; Liang Ma#; Hongzhu Qu#; Wei Chen#; Bing Zhang#; Xi Lu; Weibo Zhai; Xin Sheng; Yongqiao Sun; Wenjie Li; Meng Lei; Qiuhui Qi; Na Yuan; Shuo Shi; Jingyao Zeng; Jinyue Wang; Yadong Yang; Qi Liu; Yaqiang Hong; Lili Dong; Zhewen Zhang; Dong Zou; Yanqing Wang; Shuhui Song; Fan Liu; Xiangdong Fang; Hua Chen; Xin Liu; Jingfa Xiao*; Changqing Zeng*; Whole genome analysis of Chinese population and de novo assembly of a northern Han genome, Genomics Proteomics & Bioinformatics,2019.09.17(3):229-247.
Hao Wu#; Wei Chen#; Fei Zhao#; Qingyi Zhou; Reinach Peter S; Lili Deng; Li Ma; Shumeng Luo; Srinivasalu Nethrajeith; Miaozhen Pan; Yang Hu; Xiaomeng Pei; Jing Sun; Ran Ren; Yinghui Xiong; Zhonglou Zhou; Sen Zhang; Geng Tian; Jianhuo Fang; Lina Zhang; Jidong Lang; Deng Wu; Changqing Zeng*; Jia Qu J*; Xiangtian Zhou*; Scleral hypoxia is a target for myopia control, Proceedings of the National Academy of Sciences of the United States of America, 2018.07.24;115(30):E7091-E7100.
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