ISHII, Ken J - The University of Tokyo - The Institute of Medical Science

个人简介

Research History Apr, 2022 - PresentDirector, International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo Jan, 2019 - PresentProfessor, Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo Apr, 2010 - PresentVisiting Professor, Lab. Vaccine Science, WPI Immunology Frontier Research Center (iFREC), Osaka University Apr, 2019 - Mar, 2022Director, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo Apr, 2017 - Dec, 2018Director, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition Oct, 2015 - Mar, 2017Managing Director, Department of Research Promotion, Japan Agency for Medical Research and Development Apr, 2015 - Sep, 2015Director, Center for Drug Design Research, Natioanl Institutes of Biomedical Innvation, Health and Nutrition Apr, 2010 - Mar, 2015Project Leader, Lab. Adjuvant Innovation,, National institute of Biomedical innovation (NIBIO) Oct, 2007 - Mar, 2010Associate Professor, WPI immunology Frontier Rsearch Center (iFREC), Osaka University Dec, 2006 - Mar, 2010Associate Professor, Research Institute for Microbial Diseases, Osaka University Sep, 2003 - Oct, 2007Group Leader, JST ERATO AKIRA innate immunity project Mar, 2000 - Aug, 2003IND reviewer, Division of Viral Products, CBER, OVRR, FDA Sep, 1996 - Feb, 2000Visiting Scientist, CBER, OVRR, FDA,, US. Gov Apr, 1995 - Aug, 1996Dep. of Anesthesiology Apr, 1995 - Mar, 1996Anesthesiologist, Yokoyama City municipal hospital Apr, 1993 - Mar, 1995Resident, Yokohama City University Hospital Education 1993 Yokohama City University Yokohama City University

研究领域

Clinical trial アジュバント核酸医薬ワクチン感染症免疫学（自然免疫） Nucleic Acids Influenza virus Malaria Infectious Diseases Innate immunity Adjuvant Vaccine Immunology

近期论文

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Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome. Hachiro Konaka, Yasuhiro Kato, Toru Hirano, Kohei Tsujimoto, JeongHoon Park, Taro Koba, Wataru Aoki, Yusei Matsuzaki, Masayasu Taki, Shohei Koyama, Eri Itotagawa, Tatsunori Jo, Takehiro Hirayama, Taro Kawai, Ken J Ishii, Mitsuyoshi Ueda, Shigehiro Yamaguchi, Shizuo Akira, Takayoshi Morita, Yuichi Maeda, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Hyota Takamatsu, Atsushi Kumanogoh The EMBO journal, e112573, Sep 4, 2023 A stress sensor IRE1α is required for bacterial exotoxin-induced inflammasome activation in tissue-resident macrophages Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Takashi Orimo, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta, Hiroaki Hemmi, Takashi Kato, Asumi Yamamoto, Takashi Tanaka, Katsuaki Hoshino, Shinji Fukuda, Kensuke Miyake, Etsushi Kuroda, Ken J Ishii, Takao Iwawaki, Koichi Furukawa, Tsuneyasu Kaisho bioRxiv, Jul 7, 2023 TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells Xiao Sun, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Huangwenxian Lan, Yunru Wang, Haruki Yamaura, Takahiro Nagatake, Ken J. Ishii, Shizuo Akira, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa International Immunopharmacology, 117 109852-109852, Apr, 2023 Roles of TRPM4 in immune responses in keratinocytes and identification of a novel TRPM4-activating agent Kaori (Otsuka) Saito, Fumitaka Fujita, Manami Toriyama, Ratna Annisa Utami, Zhihan Guo, Masato Murakami, Hiroko Kato, Yoshiro Suzuki, Fumihiro Okada, Makoto Tominaga, Ken J. Ishii Biochemical and Biophysical Research Communications, Feb, 2023 A-910823, a squalene-based emulsion adjuvant, induces T follicular helper cells and humoral immune responses via α-tocopherol component. Yuya Yoshioka, Kouji Kobiyama, Tomoya Hayashi, Motoyasu Onishi, Yosuke Yanagida, Takayuki Nakagawa, Masayuki Hashimoto, Anri Nishinaka, Jun Hirose, Yoshiji Asaoka, Minako Tajiri, Atsushi Hayata, Satoru Ishida, Shinya Omoto, Morio Nagira, Ken J Ishii Frontiers in immunology, 14 1116238-1116238, 2023 Dendritic cell proliferation by primary cilium in atopic dermatitis. Manami Toriyama, Defri Rizaldy, Motoki Nakamura, Yukiko Atsumi, Michinori Toriyama, Fumitaka Fujita, Fumihiro Okada, Akimichi Morita, Hiroshi Itoh, Ken J Ishii Frontiers in molecular biosciences, 10 1149828-1149828, 2023 Anti-Inflammatory Role of TRPV4 in Human Macrophages Yukiko Atsumi, Manami Toriyama, Hiroko Kato, Motoki Nakamura, Akimichi Morita, Masayuki Takaishi, Kaori Saito, Miku Tanaka, Fumihiro Okada, Makoto Tominaga, Ken J. Ishii, Fumitaka Fujita ImmunoHorizons, 7(1) 81-96, Jan 1, 2023 Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung. Takumi Kawasaki, Moe Ikegawa, Kosuke Yunoki, Hifumi Otani, Daisuke Ori, Ken J Ishii, Etsushi Kuroda, Shiki Takamura, Masahiro Kitabatake, Toshihiro Ito, Ayako Isotani, Taro Kawai Cell reports, 41(11) 111828-111828, Dec 13, 2022 Proposal for the revision of guidelines for clinical trials of vaccines to prevent infectious diseases in Japan. Yumiko Nomura, Kiyohito Noda, Yuusuke Oohashi, Shin Okuda, Jun Matsumoto, Takashi Nakano, Nao Tsuchida, Ken J Ishii, Kunihiko Hayashi, Tatsuo Iiyama, Hiroshi Onodera, Koji Ishii, Mayumi Shikano, Nobuhiko Okabe Vaccine, 40(43) 6295-6304, Oct 12, 2022 Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen Ayaka Washizaki, Asako Murayama, Megumi Murata, Tomoko Kiyohara, Keigo Yato, Norie Yamada, Hussein Hassan Aly, Tomohisa Tanaka, Kohji Moriishi, Hironori Nishitsuji, Kunitada Shimotohno, Yasumasa Goh, Ken J. Ishii, Hiroshi Yotsuyanagi, Masamichi Muramatsu, Koji Ishii, Yoshimasa Takahashi, Ryosuke Suzuki, Hirofumi Akari, Takanobu Kato Nature Communications, 13(1), Sep 5, 2022 Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants including BA.4 and BA.5 Izumi Kimura, Daichi Yamasoba, Tomokazu Tamura, Naganori Nao, Tateki Suzuki, Yoshitaka Oda, Shuya Mitoma, Jumpei Ito, Hesham Nasser, Jiri Zahradnik, Keiya Uriu, Shigeru Fujita, Yusuke Kosugi, Lei Wang, Masumi Tsuda, Mai Kishimoto, Hayato Ito, Rigel Suzuki, Ryo Shimizu, M.S.T. Monira Begum, Kumiko Yoshimatsu, Kanako Terakado Kimura, Jiei Sasaki, Kaori Sasaki-Tabata, Yuki Yamamoto, Tetsuharu Nagamoto, Jun Kanamune, Kouji Kobiyama, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Kotaro Shirakawa, Akifumi Takaori-Kondo, Jin Kuramochi, Gideon Schreiber, Ken J. Ishii, Takao Hashiguchi, Terumasa Ikeda, Akatsuki Saito, Takasuke Fukuhara, Shinya Tanaka, Keita Matsuno, Kei Sato Cell, Sep, 2022 Safety and immunogenicity of a quadrivalent seasonal influenza vaccine adjuvanted with hydroxypropyl-β-cyclodextrin: A phase 1 clinical trial. Akane Watanabe, Sumiyuki Nishida, Temizöz Burcu, Takayuki Shibahara, Takato Kusakabe, Etsushi Kuroda, Ken J Ishii, Atsushi Kumanogoh Vaccine, 40(31) 4150-4159, Jul 29, 2022 CpG ODN (K3)-toll-like receptor 9 agonist-induces Th1-type immune response and enhances cytotoxic activity in advanced lung cancer patients: a phase I study. Tomoyuki Otsuka, Sumiyuki Nishida, Takayuki Shibahara, Burcu Temizoz, Masanari Hamaguchi, Takayuki Shiroyama, Keiko Kimura, Kotaro Miyake, Haruhiko Hirata, Yumiko Mizuno, Mayu Yagita, Yusuke Manabe, Etsushi Kuroda, Yoshito Takeda, Hiroshi Kida, Ken J Ishii, Atsushi Kumanogoh BMC cancer, 22(1) 744-744, Jul 7, 2022 Identification of RPL15 60S Ribosomal Protein as a Novel Topotecan Target Protein That Correlates with DAMP Secretion and Antitumor Immune Activation. Shunsuke Yamada, Yuichi Kitai, Takashi Tadokoro, Runa Takahashi, Haruka Shoji, Taiga Maemoto, Marie Ishiura, Ryuta Muromoto, Jun-Ichi Kashiwakura, Ken J Ishii, Katsumi Maenaka, Taro Kawai, Tadashi Matsuda Journal of immunology (Baltimore, Md. : 1950), 209(1) 171-179, Jun 20, 2022 Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike. Daichi Yamasoba, Izumi Kimura, Hesham Nasser, Yuhei Morioka, Naganori Nao, Jumpei Ito, Keiya Uriu, Masumi Tsuda, Jiri Zahradnik, Kotaro Shirakawa, Rigel Suzuki, Mai Kishimoto, Yusuke Kosugi, Kouji Kobiyama, Teppei Hara, Mako Toyoda, Yuri L Tanaka, Erika P Butlertanaka, Ryo Shimizu, Hayato Ito, Lei Wang, Yoshitaka Oda, Yasuko Orba, Michihito Sasaki, Kayoko Nagata, Kumiko Yoshimatsu, Hiroyuki Asakura, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Jin Kuramochi, Motoaki Seki, Ryoji Fujiki, Atsushi Kaneda, Tadanaga Shimada, Taka-Aki Nakada, Seiichiro Sakao, Takuji Suzuki, Takamasa Ueno, Akifumi Takaori-Kondo, Ken J Ishii, Gideon Schreiber, Hirofumi Sawa, Akatsuki Saito, Takashi Irie, Shinya Tanaka, Keita Matsuno, Takasuke Fukuhara, Terumasa Ikeda, Kei Sato Cell, 185(12) 2103-2115, Jun 9, 2022 Proposal for the revision of the guidelines for Non-clinical studies of vaccines for the prevention of infectious diseases in Japan. Yumiko Nomura, Kiyohito Noda, Yuusuke Oohashi, Shin Okuda, Kazushige Maki, Takashi Ogawa, Takashi Nakano, Nao Tsuchida, Ken J Ishii, Kunihiko Hayashi, Tatsuo Iiyama, Hiroshi Onodera, Koji Ishii, Mayumi Shikano, Nobuhiko Okabe Vaccine, 40(19) 2810-2818, Apr 26, 2022 Anti-tumor immunity by transcriptional synergy between TLR9 and STING activation. Burcu Temizoz, Kou Hioki, Shingo Kobari, Nao Jounai, Takato Kusakabe, Michelle S J Lee, Cevayir Coban, Etsushi Kuroda, Ken J Ishii International immunology, Apr 14, 2022 Making innate sense of mRNA vaccine adjuvanticity. Kouji Kobiyama, Ken J Ishii Nature immunology, 23(4) 474-476, Apr, 2022 In situ vaccination using unique TLR9 ligand K3-SPG induces long-lasting systemic immune response and synergizes with systemic and local immunotherapy. Hirokazu Okada, Ken Takahashi, Hiroaki Yaku, Kouji Kobiyama, Keiko Iwaisako, Xiangdong Zhao, Masahiro Shiokawa, Norimitsu Uza, Yuzo Kodama, Ken J Ishii, Hiroshi Seno Scientific reports, 12(1) 2132-2132, Feb 8, 2022 B cell-intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice. Michelle S J Lee, Takeshi Inoue, Wataru Ise, Julia Matsuo-Dapaah, James B Wing, Burcu Temizoz, Kouji Kobiyama, Tomoya Hayashi, Ashwini Patil, Shimon Sakaguchi, A Katharina Simon, Jelena S Bezbradica, Satoru Nagatoishi, Kouhei Tsumoto, Jun-Ichiro Inoue, Shizuo Akira, Tomohiro Kurosaki, Ken J Ishii, Cevayir Coban The Journal of experimental medicine, 219(2), Feb 7, 2022 Machine Learning-Assisted Screening of Herbal Medicine Extracts as Vaccine Adjuvants. Kou Hioki, Tomoya Hayashi, Yayoi Natsume-Kitatani, Kouji Kobiyama, Burcu Temizoz, Hideo Negishi, Hitomi Kawakami, Hiroyuki Fuchino, Etsushi Kuroda, Cevayir Coban, Nobuo Kawahara, Ken J Ishii Frontiers in immunology, 13 847616-847616, 2022 Using a new three-dimensional CUBIC tissue-clearing method to examine the brain during experimental cerebral malaria. Julia Matsuo-Dapaah, Michelle Sue Jann Lee, Ken J Ishii, Kazuki Tainaka, Cevayir Coban International immunology, Aug 29, 2021 Type I and II interferons toward ideal vaccine and immunotherapy. Burcu Temizoz, Ken J Ishii Expert review of vaccines, 1-18, Jun 9, 2021 Increase in primary cilia in the epidermis of patients with atopic dermatitis and psoriasis. Defri Rizaldy, Manami Toriyama, Hiroko Kato, Runa Fukui, Fumitaka Fujita, Motoki Nakamura, Fumihiro Okada, Akimichi Morita, Ken J Ishii Experimental dermatology, 30(6) 792-803, Jun, 2021 Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants Shuyu Jin, Hue Thi Vu, Kou Hioki, Naotaka Noda, Hiroki Yoshida, Toru Shimane, Shigenari Ishizuka, Ippei Takashima, Yoshiyuki Mizuhata, Kathleen Beverly Pe, Tetsuya Ogawa, Naoya Nishimura, Daniel Packwood, Norihiro Tokitoh, Hiroki Kurata, Sho Yamasaki, Ken J. Ishii, Motonari Uesugi Angewandte Chemie, 133(2) 974-982, Jan 11, 2021 S-540956, a CpG Oligonucleotide Annealed to a Complementary Strand With an Amphiphilic Chain Unit, Acts as a Potent Cancer Vaccine Adjuvant by Targeting Draining Lymph Nodes. Takayuki Nakagawa, Tetsuya Tanino, Motoyasu Onishi, Soichi Tofukuji, Takayuki Kanazawa, Yukichi Ishioka, Takeshi Itoh, Akira Kugimiya, Kazufumi Katayama, Takuya Yamamoto, Morio Nagira, Ken J Ishii Frontiers in immunology, 12 803090-803090, 2021 Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential. Manami Toriyama, Ken J Ishii Frontiers in cell and developmental biology, 9 621318-621318, 2021 First-in-human randomised trial and follow-up study of Plasmodium falciparum blood-stage malaria vaccine BK-SE36 with CpG-ODN(K3). Sachiko Ezoe, Nirianne Marie Q Palacpac, Kohhei Tetsutani, Kouji Yamamoto, Kiyoshi Okada, Masaki Taira, Sumiyuki Nishida, Haruhiko Hirata, Atsushi Ogata, Tomomi Yamada, Masanori Yagi, Jyotheeswara R Edula, Yuko Oishi, Takahiro Tougan, Ken J Ishii, Akira Myoui, Toshihiro Horii Vaccine, 38(46) 7246-7257, Oct 27, 2020 Strategic Outlook toward 2030: Japan's research for allergy and immunology - Secondary publication. Takeya Adachi, Keigo Kainuma, Koichiro Asano, Masayuki Amagai, Hiroyuki Arai, Ken J Ishii, Komei Ito, Eiichi Uchio, Motohiro Ebisawa, Mitsuhiro Okano, Kenji Kabashima, Kenji Kondo, Satoshi Konno, Hidehisa Saeki, Mariko Sonobe, Mizuho Nagao, Nobuyuki Hizawa, Atsuki Fukushima, Shigeharu Fujieda, Kenji Matsumoto, Hideaki Morita, Kazuhiko Yamamoto, Akemi Yoshimoto, Mayumi Tamari Allergology international : official journal of the Japanese Society of Allergology, 69(4) 561-570, Oct, 2020 The Ca2+-dependent pathway contributes to changes in the subcellular localization and extracellular release of interleukin-33. Masatoshi Momota, Mizuka Nagayama, Haruna Okude, Ken J Ishii, Daisuke Ori, Takumi Kawasaki, Taro Kawai Biochemical and biophysical research communications, 530(4) 699-705, Oct 1, 2020 Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2. Takumi Adachi, Koubun Yasuda, Taichiro Muto, Satoshi Serada, Tomohiro Yoshimoto, Ken J Ishii, Etsushi Kuroda, Kimi Araki, Masaki Ohmuraya, Tetsuji Naka, Kenji Nakanishi International immunology, 32(10) 637-652, Sep 30, 2020 Introduction: Memory and Vaccination Special Issue Ken J. Ishii, Tomohiro Kurosaki INTERNATIONAL IMMUNOLOGY, 32(9) 569-570, Sep, 2020 Heparin induces neutrophil elastase-dependent vital and lytic NET formation. Patrick M Lelliott, Masatoshi Momota, Takayuki Shibahara, Michelle S J Lee, Nicholas I Smith, Ken J Ishii, Cevayir Coban International immunology, 32(5) 359-368, May 8, 2020 IN SITU VACCINE IMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS USING NOVEL NANOPARTICULATE TLR9 AGONIST K3-SPG Hirokazu Okada, Ken Takahashi, Kouji Kobiyama, Yoshihiro Nishikawa, Masahiro Shiokawa, Norimitsu Uza, Yuzo Kodama, Hiroshi Seno, Ken J. Ishii GASTROENTEROLOGY, 158(6) S195-S195, May, 2020 Characteristic of K3 (CpG-ODN) as a Transcutaneous Vaccine Formulation Adjuvant. Sayami Ito, Sachiko Hirobe, Takuto Kawakita, Mio Saito, Ying-Shu Quan, Fumio Kamiyama, Ken J Ishii, Mizuho Nagao, Takao Fujisawa, Masashi Tachibana, Naoki Okada Pharmaceutics, 12(3), Mar 15, 2020 ZBP1 governs the inflammasome-independent IL-1α and neutrophil inflammation that play a dual role in anti-influenza virus immunity. Masatoshi Momota, Patrick Lelliott, Atsuko Kubo, Takato Kusakabe, Kouji Kobiyama, Etsushi Kuroda, Yumiko Imai, Shizuo Akira, Cevayir Coban, Ken J Ishii International immunology, 32(3) 203-212, Mar 7, 2020 Immunological role of primary cilia of dendritic cells in human skin disease Manami Toriyama, Defri Rizaldy, Motoki Nakamura, Fumitaka Fujita, Fumihiro Okada, Akimichi Morita, Ken J. Ishii Feb 4, 2020 IL-33 Is Essential for Adjuvant Effect of Hydroxypropyl-β-Cyclodexrin on the Protective Intranasal Influenza Vaccination. Shingo Kobari, Takato Kusakabe, Masatoshi Momota, Takayuki Shibahara, Tomoya Hayashi, Koji Ozasa, Hideaki Morita, Kenji Matsumoto, Hirohisa Saito, Shuichi Ito, Etsushi Kuroda, Ken J Ishii Frontiers in immunology, 11 360-360, 2020