Uesugi, Motonari - Kyoto University - Institute for Chemical Research

研究领域

As biological processes all stem from chemical events, it should be possible to understand or manipulate biological events by using chemistry. As chemical biologists our challenge is to discover or design unique organic molecules, 'super tools' that modulate fundamental processes in human cells. Using these 21st century super tools we can explore complex cellular events. Our job is creation: designing a new world of bioactive synthetic molecules, with unique and novel uses, forms and sizes. The future for small-molecule applications is open before us, in a range of fields, including future drug discovery and cell therapy. Our 21st century technology and skills will revolutionize the fight against the most difficult diseases and medical challenges of the age.

近期论文

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Small-Molecule Drug Repurposing for Counteracting Phototoxic A2E Aggregation Perron, A., Mandal, S., Chuba, T., Mao, D., Singh, V., Noda, N., Tan, R., Vu, H., Abo, M., Uesugi, M. ACS Chem. Biol. (in press) (2023) Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile Zhuo, S., Noda, N., Hioki, K., Jin, S., Hayashi, T., Hiraga, K., Momose, H., Li, W., Zhao, L., Mizukami, T., Ishii, K., Li, Y., Uesugi, M. J. Med. Chem. (in press) (2023) Chemoproteomic Identification of Blue-Light-Damaged Proteins Toh, K., Nishio, K., Nakagawa, R., Egoshi, S., Abo, M., Perron, A., Sato, S., Okumura, N., Koizumi, N., Dodo, K., Sodeoka, M., Uesugi, M. J. Am. Chem. Soc. 144(44), 20171–20176 (2022) Self-assembling small-molecule adjuvants as antigen nano-carriers Jin, S., Zhuo, S., Takemoto, Y., Li, Y., Uesugi, M. Chem. Comm. 58, 12228-12231 (2022) Magnetic Control of Cells by Chemical Fabrication of Melanin Nishio, K., Toh, K., Perron, A., Goto, M., Abo, M., Shimakawa, Y., Uesugi, M. J. Am. Chem. Soc. 144(37), 16720–16725 (2022) Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells Ado, G., Noda, N., Vu, H., Perron, A., Mahapatra, A., Arista, K., Yoshimura, H., Packwood, D., Ishidate, F., Sato, S., Ozawa, T., Uesugi, M. Chemical Science 13, 5760-5766 (2022) Glucose as a Protein-Condensing Cellular Solute Noda, N., Jung, Y., Ado, G., Mizuhata, Y., Higuchi, M., Ogawa, T., Ishidate, F., Sato, S., Kurata, H., Tokitoh, N., Uesugi, M. ACS Chem. Biol. 17(3), 567–575 (2022) Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe Jung, Y., Noda, N., Takaya, J., Abo, M., Toh, K., Tajiri, K., Cui, C., Zhou, L., Sato, S., Uesugi, M. ACS Chem. Biol. 17(2), 340–347 (2022) Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite. Mendoza, A., Takemoto, Y., Cruzado, K., Masoud, S., Nagata, A., Tantipanjaporn, A., Okuda, S., Kawagoe, F., Sakamoto, R., Odagi, M., Mototani, S., Togashi, M., Kawatani, M., Aono, H., Osada, H., Nakagawa, H., Higashi, T., Kittaka, A., Nagasawa, K., Uesugi, M. Cell Chemical Biology 29(4), 660-669 (2022) Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis Takemoto, Y., Kadota, S., Minami, I., Otsuka, S., Okuda, S., Abo, M., Punzalan, L., Shen, Y., Shiba, Y., Uesugi, M. Angew. Chem. Int. Ed. 60(40), 21824-21831 (2021) Non-genetic cell-surface modification with a self-assembling molecular glue. Hakariya, H., Takashima, I., Takemoto, M., Noda, N., Sato, S., Uesugi, M. Chem. Comm. 57(12), 1470-1473 (2021) Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants. Jin, S., Vu, H., Hioki, K., Noda, N., Yoshida, H., Shimane, T., Ishizuka, S., Takashima, I., Mizuhata, Y., Pe, K., Ogawa, T., Nishimura, N., Packwood, D., Tokitoh, N., Kurata, H., Yamasaki, S., Ishii, K., Uesugi, M. Angew. Chem. Int. Ed. 60(2), 961-969 (2021) Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library. Punzalan, L., Jiang, L., Mao, D., Mahapatra, A., Sato, S., Takemoto, Y., Tsujimura, M., Kusamori, K., Nishikawa, M., Zhou, L., Uesugi, M. Cell Chemical Biology 27(6), 708–718 (2020) Discovery of a Small-Molecule-Dependent Photolytic Peptide. Takemoto, Y., Mao, Di., Punzalan, L., Götze, S., Sato, S., Uesugi, M. J. Am. Chem. Soc. 142(3), 1142-1146 (2020) Synthetic Chemical Probes That Dissect Vitamin D Activities. Nagata, A., Akagi, Y., Asano, L., Kotake, K., Kawagoe, F., Mendoza, A., Masoud, S., Usuda, K., Yasui, K., Takemoto, Y., Kittaka, A., Nagasawa, K., Uesugi, M. ACS Chem. Biol. 14(12), 2851–2858 (2019) Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators. Furuta,T., Mizukami, Y., Asano, L., Kotake, K., Ziegler, S., Yoshida, H., Watanabe, M., Sato, S., Waldmann, H., Nishikawa, M., Uesugi, M. ACS Chem. Biol. 14(9), 1860-1865 (2019) Multifunctionalization of cells with a self-assembling molecule to enhance cell engraftment. Takashima, I., Kusamori, K., Hakariya, H., Takashima, M., Vu, TH., Mizukami, Y., Noda, N., Takayama, Y., Katsuda, Y., Sato, S., Takakura, Y., Nishikawa, M., Uesugi, M. ACS Chem. Biol., 14(4), 775–783 (2019) Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. Perron, A., Nishikawa, Y., Iwata, J., Shimojo, H., Takaya, J., Kobayashi, K., Imayoshi, I., Mbenza, N. M,, Takenoya, M., Kageyama, R., Kodama, Y., Uesugi, M. J. Biol. Chem. 293(21), 8285-8294 (2018) Chemical decontamination of iPS cell-derived neural cell mixtures. Mao, D., Chung, X. K. W., Andoh-Noda, T., Qin, Y., Sato, S., Takemoto, Y., Akamatsu, W., Okano, H., Uesugi, M. Chem. Commun. 54, 1355-1358 (2018)