Nuttall, Pat - University of Oxford - Department of Zoology

研究领域

Blood-feeding arthropods such as mosquitoes and ticks act as vectors, transmitting numerous viruses (arthropod-borne viruses = arboviruses), bacteria, protozoa and other pathogens to animals, including humans. My interest is in the role of vector saliva in pathogen transmission. I am trying to unravel the complexity of tick saliva, which contains 100s of molecules that help the tick to feed, including anticoagulants and immunomodulators. The remarkable activities of these molecules are exploited by vector-borne pathogens, promoting their transmission. We also can exploit these molecules to develop vaccines and new therapeutic drugs.

近期论文

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Valdés, J.J., Cabezas-Cruz, A., Sima, R., Butterill, P.T., Ruzek, P.T., and Nuttall, P.A. (2016). Substrate prediction of Ixodes ricinus salivary lipocalins differentially expressed during Borrelia afzelii infection. Scientific Reports 6:32372e Daniel, M., Malý, M., Danielová, V., Kriz, B. and Nuttall, P. (2015). Abiotic predictors and annual seasonal dynamics of Ixodes ricinus, the major disease vector of Central Europe. Parasites and Vectors 8:478. Slovák, M., Kazimírová, M., Siebenstichová, M., Ustaníková, K., Klempa, B., Gritsun, T., Gould, E.A., Nuttall, P.A. (2014). Survival dynamics of tick-borne encephalitis virus in Ixodes ricinus ticks. Ticks and Tick-borne Diseases 5: 962-969. Pekáriková, D., Rajská, P., Kazimírová, M., Pechánová, O., Takác, P., and Nuttall, P.A. (2015). Vasoconstriction induced by salivary gland extracts from ixodid ticks. International Journal of Parasitology 45: 879-883. Slovák, M., Štibrániová, I., Hajnická, V. and Nuttall, P.A. (2014). Antiplatelet-derived growth factor (PDGF) activity in the saliva of ixodid ticks is linked with their long mouthparts. Parasite Immunology 36, 32-42. Preston, S.G., Majtán, J., Kouremenou, C., Rysnik, O., Burger, L.F., Cruz, A.C., Guzman, M.C., Nunn, M.A., Paesen, G.C., Nuttall, P.A. and Austyn, J.A. (2013). Novel immunomodulators from hard ticks selectively reprogramme human dendritic cell responses. PLoS Pathogens 9, e1003450.