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教育及工作经历 工作经历 - 学术 2019.04 – 至今 教授 北京航空航天大学 生物与医学工程学院 所长 北京市生物医学工程高精尖研究中心 单细胞工程研究所 2017.08– 2019.03 助理教授 北德克萨斯大学 (美国) (TenureTrack) 生物医学工程系 2016.09– 2017.06 博士后 西北大学(美国) 机械工程系 PI: Horacio Espinosa? ?美国工程院院士 CCNE国家纳米科学中心 PI: Chad Mirkin 美国科学院、工程院、AAAS、医学院院士 工作经历 - 产业化 2021.06— 至今 创始人 北京载愈生物技术公司(Pre-A轮,估值1.5亿) 教育背景 2011.09– 2016.06 博士 俄亥俄州立大学 - 生物医学工程 导师:L. James Lee (Helen Kurtz讲席教授) Wu Lu (ECE Professor) 2008.09– 2011.06 硕士 中国科学院电子学研究所?传感技术国家重点实验室 - 生物电子学 导师:蔡新霞(国家杰青) 2004.08–2008.07 学士 大连理工大学 科研经费与获奖 主持科研经费 2022.10 - 2025.10 负责人 十四五’重点研发计划课题 科技部 419 万 “教育部人才奖励计划” 教育部 国家高层次海外人才项目 ZZB 2019.04-2021.12 负责人 北京市生物医学工程高精尖中心——单细胞工程研究所 北京市教委 600万 2021.06- 2023.06 主持 载愈-北航联合研发项目 载愈生物 460 万 2021.01– 2024.12 主持 面上项目 国家自然科学基金 62 万 2021.01– 2023.12 主持 青年项目 国家自然科学基金 24 万 2021.01– 2023.12 主持 面上项目 北京市自然科学基金 20 万 2020.08– 2021.01 主持 概念验证项目 北京市海淀区 60 万 2020.01– 2021.12 共同主持 重点研发专项 四川省科技厅 60 万 2019.12- 2020.12 主持 精科-北航联合研发项目(横向) 广州精科 114 万 2020.06– 2021.06 主持 无创可穿戴传感器研发项目(横向) 京东方(BOE) 广州仁康 120 万 获奖和荣誉 2022 科技新锐人物奖 中国科协/知社 2022 青年科学家奖? ? Micro and Nano Engineering (Elsevier) 2022 科技创新大赛三等奖 HICOOL 2021 Emerging Investigator Nanoscale (RSC) 2018 青年科学家 Microsystemand Nanoengineering (Nature) 2018 RSG Award 美国北德克萨斯大学 2016 研究生奖 EIPBN?InternationalConference 2016 校长奖(博士最高奖) 美国俄亥俄州立大学 2013 NSEC Fellowship 美国国家科学委员会(NSF) 2011 University Fellowship 美国俄亥俄州立大学 2008 研究生院奖学金 中国科学院 2008 优秀毕业生 大连理工大学 社会兼职 学术期刊兼职 2022 Editorial Board Micro and Nano Engineering (IF:5.6) 2022 Editorial Board VIEW (IF:10) 2021 Editorial Board Biosensors and Bioelectronics X (IF:4) 2021 Editorial Board Biosensors (IF:5.7) 2021 Editorial Board Medicine in Novel Technology and Devices 2019 Editorial Board Nanotechnology and Precision Engineering 2018 Associate Editor BioMedical Engineering Online (IF:3.2) 2014 Editorial Board Computers in Biology and Medicine (IF: 6) 学会、国际学术组织任职 2023 中国微纳技术学会 生物微机电系统分会 理事、委员 2021 国家十四五‘前沿生物技术’重点研发专项指南组 成员 2023 中国生物医学工程学会,纳米医药分会 委员 2023 中国医药教育学会智能心血管病学分会 委员 2022 国际科学组织Vebleo协会 Fellow 2021 中国微纳技术学会,青委会 委员 2021 中国抗肿瘤学会 肿瘤标记专委会 单细胞协作组 委员 2019 中国生物医学工程学会,纳米医药分会 青年委员 学术会议任职 2022 中国生物物理学会纳米医药分会年会组委会 委员 2022 中国微纳技术学会年会组委会 委员 2021 中国微纳技术学会年会组委会 委员 2019 第二届细胞信息学研讨会 主席(共同主席:顾宁院士) 2019 Microsystem and Nanoengineering 年会组委会 委员 2018 Second Texas Symposium on Computing with EmergingTechnologies (Dallas, Texas) Session Chair 期刊审稿人 2012– 至今 50多个SCI检索期刊的审稿人,包括Nature, AAAS,ACS, WILEY, RSC, Elsevier, IEEE,ASME等,例如:Nature Biomedical Engineering, Science Advances, Advanced FunctionalMaterials, ACS Nano, Small, Research 2017 AnnualDistinguished Reviewer Journals of Micromechanics and Microengineering 2015 AnnualDistinguished Reviewer Materials Science and Engineering C 2014 AnnualDistinguished Reviewer Computers in Biology and Medicine

研究领域

纳米电穿孔(Nano-electroporation)、细胞诊疗、生物芯片、生物传感

近期论文

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Equal Contribution;* Correspondence) X. Jiang, ... L. Chang, Recent Advances in Bioelectronics for Localized Drug Delivery, Small Methods, 2023. X.W. Xiang, et al. Revolutionizing wound healing: Ultrashort pulse electric fields in seconds for highly aligned extracellular matrix and efficient cell migration, Chemical Engineering Journal, 2023. LiyingJiang, Xianghao Lan, Linjiao Ren, ZhiyuanJin, Xuchen Shan, Mingzhu Yang, Lingqian Chang*, Single-moleculeRNA capture assisted droplet digital LAMP for ultrasensitive and rapid detectionof infectious pathogens, Microsystem & Nanoengineering, 2023. Fenqi Wan, Zaizai Dong, Bin Liu, Shi Yan, Minzhu Yang, Lingqian Chang*, Sensitive Interrogation of Enhancer Activity in Living Cells on Nanoelectroporation-Probing Platform, ACS Sensors, 2022. Yuqiong Wang, Anan Sheng, Xinran Jiang, Shanshan Yang, Long Lin, Mingzhu Yang, Fengshuo Zhu, Yongyan Hu, Jian Li, Lingqian Chang*, Multi-drug Dissovable Microneedle Patch for the Treatment of Recurrent Oral Ulcer, Bio-Design and Manufacturing, 2022. ChaohaoChen, Lei Ding, Baolei Liu*, Ziqing Du, Yongtao Liu, Xiangjun Di, XuchenShan, Chenxiao Lin, Min Zhang, Xiaoxue Xu, Xiaolan Zhong, JianfengWang, Lingqian Chang, Benjamin Halkon, Xin Chen, FaliangCheng*, Fan Wang*, Exploiting Dynamic Nonlinearity in Upconversion Nanoparticles for Super-Resolution Imaging, Nano Letters, 2022. X. Wang et al. Fast Solidification of Pure Gallium at Room Temperature and its Micromechanical Properties, Advanced Material Interface, 2022. Chi-Ling Chiang, Eileen Y. Hu, Lingqian Chang, Jadwiga Labanowska, Kevan Zapolnik, Xiaokui Mo, Junfeng Shi, Tzyy-Jye Doong, ArlettaLozanski, Pearlly S. Yan, Ralf Bundschuh, Logan A. Walker, DanielGallego-Perez, Wu Lu, Meixiao Long, Sanggu Kim, Nyla A. Heerema, GerardLozanski, Jennifer A. Woyach, John C. Byrd, Ly James Lee, Natarajan Muthusamy*. Leukemia-initiating HSCs in chronic lymphocytic leukemiareveal clonal leukemogenesis and differential drug sensitivity. Cell Reports, 2022, Vol40(3), 111115. Yang Wang, Hong Sun,Gaolian Xu, Mengdi Guan, Qingyang Zhang, Zhiying Wang,Zaizai Dong, Wenhui Chen , Xiaoxiao Yang , Anbang Qiao , Yubo Fan, Xinxia Cai, Zhou Chen, Lingqian Chang* , Bo Wei, A multiplexed electrochemical quantitative polymerase chain reaction platform for single-base mutation analysis, Biosensors and Bioelectronics. 2022, Vol214, 114496. Hu Li, Tianrui Chang, Yansong Gai, Kui Liang, Yanli Jiao, Dengfeng Li, XinranJiang, Yang Wang, Xingcan Huang, Han Wu, Yiming Liu, Jian Li, Yiming Bai, KaiGeng, Nianrong Zhang, Hua Meng, Dongsheng Huang*, Zhou Li*, Xinge Yu*, Lingqian Chang*. Human joint enabled flexible self-sustainable sweat sensors. Nano Energy, 2022, Vol192. Y. Liu, X. Huang, J. Zhou, C. Yiu, Z. Song, W. Huang, SK. Nejad, H. Li, T. Wong,K. Yao, L. Zhao, W. Yoo, L. Park, Y. Huang, HR. Lam, E. Song, X. Guo, Y. Wang, Z. Dai*, Lingqian Chang*. W. L*, Z. Xie*, X. Yu*, Stretchable Sweat-activated Battery in Skin-Integrated Electronics for Continuous WirelessSweat Monitoring, Advanced Science, 2022, Vol9. Yan Sheng,# Zena Huang,# Tenghua Zhang,# Feiyang Qian, Yuqing Zhu, Zaizai Dong,Qingyang Zhang, Qi Lei, Fanhui Kong, Yuqiong Wang, Maddie Walden, StefanWuttke, Lingqian Chang,* Wei Zhu,* Jiaming Hu*,Living Cell Nanoporationand Exosomal RNA Analysis Platform for Real-Time Assessment of Cellular Therapies,Journal of the American Chemical Society. 2022, Vol144:21, 9443-9450. Xinxin Hang#, Shiqi He#, Zaizai Dong#, Yun Li, Zheng Huang, Yanruo Zhang, Hong Sun,Long Lin, Hu Li, Yang Wang, Bing Liu, Nan Wu, Tianling Ren, Yubo Fan, JizhongLou, Ruiguo Yang, Lan Jiang*, Lingqian Chang*. High-throughputDNA Tensioner Platform for Interrogating Mechanical Heterogeneity of SingleLiving Cell. Small. 2022, Vol18:12. Zhiying Wang, Yang Wang*, Long Lin, Tao Wu, Zhenzhen Zhao, Binwu Ying*, LingqianChang*. A finger-driven disposable micro-platform based on isothermalamplification for the application of multiplexed and point-of-care diagnosis oftuberculosis. Biosensors and Bioelectronics, 2022, Vol195. Hong Sun #, Zaizai Dong #, *, Qingyang Zhang #, Bing Liu , Shi Yan , YusenWang , Dedong Yin , Yang Wang , Peigen Ren, Nan Wu , Lingqian Chang *.Companion-Probe & Race Platform for Interrogating Nuclear Protein andMigration of Living Cells. Biosensors and Bioelectronics, 2022,Vol210. Tianrui Chang #, Hu Li #, Nianrong Zhang #, Xinran Jiang , Xinge Yu ,Qingde Yang , Zhiyuan Jin , Hua Meng*, Lingqian Chang *.Highly Integrated Watch for Noninvasive Continual Glucose Monitoring. Microsystems& Nanoengineering. 2022, Vol8:1. Yang Wang, Huiren Xu, Zaizai Dong, Zhiying Wang , Zhugen Yang, XingeYu*, Lingqian Chang *. Micro/nano biomedical devices forpoint-of-care diagnosis of infectious respiratory diseases. Medicine in Novel Technology and Devices, 2022,Vol14 ZaizaiDong#, Yu Wang#, Dedong Yin, Xinxin Hang, Lei Pu, Jianfu Zhang, Jia Geng*, LingqianChang*. Advanced Techniques for Gene Heterogeneity Research:Single-cell Sequencing and On-chip Gene Analysis Systems. VIEW. 2022, Vol3:1. Jiahui He, Zhaoqian Xie, Kuanming Yao, Dengfeng Li, Yiming Liu, Zhan Gao ,Wei Lu , Lingqian Chang, Xinge Yu*. Trampolineinspiredstretchable triboelectric nanogenerators as tactile sensors for epidermalelectronics. Nano Energy. 2021, Vol81, 105590. Long Lin#, Yuqiong Wang#, Minkun Cai#, Xinran Jiang, Yongyan Hu, Zaizai Dong, DedongYin, Yilin Liu, Shaohua Yang, Zhiguang Liu, Jian Zhuang,* Ye Xu, Chuan FeiGuo,* Lingqian Chang*, Multimicrochannel Microneedle MicroporationPlatform for Enhanced Intracellular Drug Delivery. Advanced Functional Materials, 2021, Vol32(21). Zaizai Dong#, Shi Yan#, Bing Liu, Yongcun Hao, Long Lin, Tianrui Chang, Hong Sun,Yusen Wang, Hu Li, Han Wu, Xinxin Hang, Shiqi He, Jiaming Hu, Xinying Xue*, NanWu*, Lingqian Chang*. Single Living Cell Analysis Nano-platformfor High-Throughput Interrogation of Gene Mutation and Cellular Behavior. Nano Letters. 2021, 21(11): 4878-4886. XinxinHang#, Shiqi He#, Zaizai Dong, Grayson Minnick, Jordan Rosenbohm, Zhou Chen,Ruiguo Yang*, Lingqian Chang*. Nanosensors for single cellmechanical interrogation. Biosensors and Bioelectronics. 2021, Vol179 Yang Wang#, Kaiju Li, Gaolian Xu, Chuan Chen, Guiqin Song, Zaizai Dong, Long Lin, YuWang, Zhiyong Xu, Mingxia Yu, Xinge Yu, Binwu Ying*, Yubo Fan*, Lingqian Chang*, Jia Geng*. Low-Cost and Scalable Platform with MultiplexedMicrowell Array Biochip for Rapid Diagnosis of COVID-19. Research, 2021. ZaizaiDong, Lingqian Chang*. Recent Electroporation-based Systems forIntracellular Molecule Delivery. Nanotechnology and Precision Engineering.2021, Vol4: 045001. (邀请综述) Hu Li, Shaochun Gu, Qianmin Zhang, Enming Song, Tairong Kuang, Feng Chen*, XingeYu*, Lingqian Chang*. Recent advances in biofluid detection withmicro/nanostructured bio-electronic devices. Nanoscale, 2021,Vol13(6): 3436-3453. An’an Sheng, Long Lin, Jia Zhu, Jian Zhuang, Jian Li*, Lingqian Chang*, Huanyu Cheng*. Micro/nanodevices for assessment and treatment in stomatologyand ophthalmology. Microsystems & Nanoengineering, 2021,Vol7(1). ZaizaiDong#, Xinying Xue#, Hailun Liang*, Jingjiao Guan*, Lingqian Chang*. DNA Nanomachines forIdentifying Cancer Biomarkers in Body Fluids and Cells. Analytical Chemistry. 2021, 93(4): 1855-1865. J.Brook, G. Minnick, P. Mukherjee, A. Jaberi, L. Chang*, H.Espinosa*, R. Yang*, High Throughput and Highly Controllable Methods for In VitroIntracellular Delivery. Small, 2020, Vol16(51). DOI: 10.1002/smll.202004917. J. He, Z.Xie, K.Yao, D.Li, Y.Liu, Z.Gao, W.Lu, L.Chang, X.Yu, Trampoline Inspired Stretchable Triboelectric Nanogenerators as Tactile Sensors for Epidermal Electronics, Nano Energy, 2020. DOI: 10.1016/j.nanoen.2020.105590 Y. Liu, H. Zheng, L. Zhao, S. Liu, K. Yao, D. Li, C. Yiu, S. Gao, R. Avila, C. Pakpong,L. Chang*, Z. Wang*, X. Huang*, Z. Xie*, Z. Yang*, X. Yu*, Electronic Skin from High-throughput Fabrication of Intrinsically Stretchable Lead ZirconateTitanate Elastomer, Research, 2020. DOI: 10.34133/2020/1085417 P.Mukherjee, E.J. Berns, C.A. Patino, E.M. Moully, L. Chang, S.S.P.Nathamgari, J. Kessler, M. Mrksich, H.D. Espinosa, Temporal Sampling of Enzymes from Live Cells by Localized Electroporation and Quantification of Activity by SAMDI Mass Spectrometry, Small, 2020, Vol16(26), DOI: 10.1002/smll.202000584 Q.Zhang, X. Wei, Y. Li, Z. Dong, F. Chen, M. Zhong, J. Shen, Z. Liu, L. Chang*, Adjustable and ultrafast light-cure hyaluronic acid hydrogel:promoting biocompatibility and cell growth, Journal of Material Chemistry B, 2020, Vol8(25): 5441-5450. DOI: 10.1039/c9tb02796c. P.Chen, J. Guo, M. Nouri, Q. Tao, Z. Li, Q. Li, L. Du, H. Chen, Z. Dong, L. Chang*, Y. Liu, L. Liao and Y. Hu*,Microfluidic Solution-Processed Organic and Perovskite Nanowires Fabricated for Field-Effect Transistors and Photodetectors, Journal of Material Chemistry C, 2020, Vol8(7): 2353-2362. DOI:10.1039/C9TC05628A. Z. Dong, Y. Jiao, Y. Hao, P. Wang, J. Shi, W. An, C. Chichtrakar, S. Black, L.J. Lee, M. Li, Y. Fan, L. Chang*, On-Chip Multiplexed Single-cell Pattern and Controllable Intracellular Delivery. Microsystem and Nanoengineering, 2020, Vol6(1). DOI:10.1138/s41378-019-0112-z. L. Chang, Y. Wang, F. Ershad, R. Yang, C. Yu, Y. Fan, Wearable Devices for Single Cell Sensing and Transfection. Trends in Biotechnology, 2019, Vol37(11):1175-1188. DOI: 10.1016/j.tibtech.2019.04.001 Y. Zhu, J. Shen, L.Yin, X. Wei, F. Chen*, M. Zhong, Z. Gu, Y. Xie, W. Jin, Z. Liu, C. Chitrakar, L. Chang,Directly photopatterning of polycaprolactone-derived photocured resin by UV-initiated thiol-ene “click” reaction: Enhanced mechanical property and excellent biocompatibility. Chemical Engineering Journal, 2019, 366, 112-122.DOI:10.1016/j.cej.2019.02.045 F. Chen, Y. Zhu, W.Li, J. Yang, P. Fan, M. Zhong, L. Chang*, Tairong Kuang*, Light-triggeredpH/Thermal Multi-Sensitive Polyelectrolyte/ITO Glass Hybrid Electrode. Applied Surface Science. 2019, 464, 273-279. DOI: 10.1016/j.apsusc.2018.09.083 J. Ju, X. Peng, K. Huang, L. Li, X. Liu, C. Chitrakar, L. Chang, Z. Gu,T. Kuang, High-performance porous PLLA-based scaffolds for bone tissue engineering: Preparation, characterization, and in vitro and in vivo evaluation. Polymer, 2019, 180, 121-707. DOI: 10.1016/j.polymer. 2019.121707 Su, YC, Cockerill, I, Y Wang,YX Qin, L Chang*, Y Zheng*, D Zhu*, Zinc-based biomaterials for regeneration and therapy.? Trends in Biotechnology, 2019, Vol37(4): 428-441. DOI: 10.1016/j.tibtech.2018.10.009 X. Wei, J. Shen, Z. Gu, Y. Zhu, F. Chen*, M. Zhong, L. Yin, Y. Xie, Z. Liu, W. Jin, M. Nouri, L.Chang*, Bioinspired pH-Sensitive Surface on Bioinert Substrate, ACS Applied BioMaterials. 2018, 1, 2167-2175. W. Bai, T. Kuang*, C. Chitrakar, R. Yang, S. Li, D. Zhu, L. Chang*, Patchable Micro/nanodevice Interacting With Skin. Biosensors and Bioelectronics. 2018, 122, 189-204. DOI: 10.1016/j.bios.2018.09.035 H. Suo, Z. Wang, G. Dai, J. Fu, J. Yin*, L. Chang*, Polyacrylonitrile Nerve Conduits with Inner Longitudinal Micro-Grooves Enhance Neuron Directional Outgrowth.? IEEE Journal of Microelectromechanical Systems. 2018, Vol27(3): 457 – 463. DOI: 10.1109/JMEMS.2018.2810097 Z. Zhou, F. Chen, T. Kuang, L. Chang, J. Yang, P. Fan, Z. Zhao, M. Zhong, Lignin-derived mesoporous carbon and NiOhybrid nanosphere with exceptional Li-ion battery and pseudo capacitive properties, Electrochimica Acta, 2018, 274, 288 -297. DOI: 10.1016/j.electacta.2018.04.111 D. Li, Z. Wan, Y. Jiao, X. Ouyang, L. Chang*, X. Wang*, Bifunctional MoS2 coatedmelamine-formaldehyde Sponges for Efficient Oil-Water Separation and Water-Soluble Dye Removal. Applied Materials Today, 2017, 9, 551 -559. DOI: 10.1016/j.apmt.2017.09.013 W. Li, T. Kuang, X. Jiang, J. Yang, P. Fan, Z. Zhao, Z. Fei, M. Zhong, L. Chang*, F. Chen*, Photoresponsive Polyelectrolyte/Mesoporous Silica Hybrid Materials with Remote-Controllable Ionic Transportation. Chemical Engineering Journal. 2017.322, 445- 453. DOI: 10.1016/j.cej.2017.04.048 D. Gallego-Perez, D.Pal, S. Ghatak, V. Malkoc, N. Higuita-Castro, S. Gnyawali, L. Chang, W. Liao, J. Shi, M. Sinha, K. Singh, E. Steen, A. Sunyecz, R. Stewart, J. Moore, T. Ziebro, R. Northcutt, M. Homsy, P. Bertani, W. Lu, S. Roy, S. Khanna, C. Rink,V.B. Sundaresan, J. Otero, L.J. Lee*, C. K. Sen*, Topical tissue nano-transfectionmediates non-viral stroma reprogramming and rescue. Nature Nanotechnology. 2017, Vol12(10): 974-979. DOI: 10.1038/NNANO.2017.134 L. Chang, F. Chen, X. Zhang, T. Kuang, M. Li, J. Hu, J. Shi, L. J. Lee, H. Chen, Y. Li, Synthetic Melanin E-ink. ACS Applied Materials & Interfaces. 2017, Vol9(19): 16553-16560. DOI: 10.1021/acsami.7b03890 T. Kuang#, L. Chang#*, X. Peng, X. Hu, D. Gallego-perez, Molecular beacon nano-sensorsprobing living cancer cells. Trends in Biotechnology. 2017, Vol35(4): 347-359. DOI: 10.1016/j.tibtech. 2016.09.003 F. Chen, Z. Zhou, L. Chang, T. Kuang, Z. Zhao, P. Fan, J. Yang, M. Zhong, Synthesis and Characterization of Lignosulfonate-Derived Hierarchical Porous Graphitic Carbons for Electrochemical Performances. Microporous and Mesoporous Materials. 2017, 247, 184-189. DOI: 10.1016/j.micromeso. 2017.03.010 T.Kuang, F. Chen, L. Chang, X.Peng, X. Gong, Facile Preparation of Open-cellular Porous Poly (L-lactic acid) Scaffold by Supercritical Carbon Dioxide Foaming for Tissue EngineeringApplications.? Chemical Engineering Journal. 2017, 307, 1017-1025. DOI: 10.1016/j.cej.2016.09.023 T.Kuang, L. Chang, D. Fu, J.Yang, M. Zhong, F. Chen, X. Peng, Improved Crystallizability and Process abilityof Ultrahigh Molecular Weight Polyethylene Modified by Poly (amido amine) Dendrimers, Polymer Engineering & Science. 2017, Vol57(2): 153-160. DOI: 10.1002/pen.24396 L. Chang, L. Li, J. Shi, Y. Sheng, W. Lu, D. Gallego-Perez, L. J. Lee. Micro-/nano-scale electroporation.Lab Chip. 2016, Vol16(21): 4047-4062. DOI: 10.1039/c6lc00840b L. Chang, D. Gallego-perez, C. Chiang, P. Bertani, T. Kuang, F. Chen, Y. Sheng, Z. Chen, J.Shi, H. Yang, V. Malkoc, W. Lu, L. J. Lee, Controllable Large-scale Transfectionof Primary Mammalian Cardiomyocytes on a Nanochannel Array Platform. Small. 2016, Vol12(43):5971-5980. DOI: 10.1002/smll.201601465 (Cover Story) D. Gallego-Perez#, L. Chang#, J. Shi, J. Ma, S.H. Kim, X. Zhao, V. Malkoc, X. Wang, M. Minata, K. J. Kwak, Y. Wu, G. Lafyatis, W. Lu, D. J. Hansford, I. Nakano, L. J. Lee, On-chip clonal analysis of glioma stem cells motility and therapy resistance.? ?Nano Letters. 2016, Vol16(9): 5326-5332. DOI: 10.1021/acs.nanolett.6b00902 L. Chang, P. Bertani, D. Gallego-Perez, Z. Yang, C. L. Chiang, V. Malkoc, L. J. Lee, W. Lu. 3D nanochannel electroporation for high-throughput cell transfection with high uniformity and dosage control. Nanoscale. 2016, Vol8(1): 243-252. DOI: 10.1039/c5nr03187g (ESI Highly cited paper) (Cover Story) (Annual HOT Article) L. Chang, J. Hu, F. Chen, J. Shi, Z. Yang, Y. Li, L. J. Lee, Nanoscale bio-platforms for living cell interrogation: current status and future perspectives. Nanoscale. 2016, Vol8(6): 3138-3206. DOI: 10.1039/c5nr06694h T. Kuang#, L. Chang#, F. Chen, Y. Sheng, D. Fu, X. Peng, Facile preparation of light weight high-strength biodegradable polymer nanocomposite foams for electro magnetic interference shielding.? Carbon. 2016, 105, 305-313. DOI: 10.1016/j.carbon.2016.04.052 (ESI Highly cited paper) Y. Sheng, L. Chang*, J. Hu, T. Kuang, PEG/heparin decorated lipid-polymer hybrid nanoparticles for long-circulating drug delivery.? RSC Advances. 2016. Vol6(28): 23279-23287. DOI: 10.1039/c5ra26215a T. Kuang, F. Chen, D. Fu, L. Chang, X. Peng, L. J. Lee, Enhanced Strength and Foamability of High-Density Polyethylene Prepared by Pressure-Induced Flow and Low-Temperature Crosslinking. RSC Advance. 2016, Vol6(41):34422-24427. DOI:10.1039/c6ra05238j K. Gao, X. Huang, C. L. Chiang, X. Wang, L. Chang, P. Boukany, G. Marcucci, R. Lee, L. J. Lee, Induced Apoptosis Investigation in Wild–Type and FLT3-ITD Acute Myeloid Leukemia Cells by Nanochannel Electroporation and Single Cell qRT-PCR, Molecular Therapy, 2016, Vol24(5): 956-964. DOI: 10.1038/mt.2016.6 Z. Chen, A. Zhang, Z. Yang, X. Wang, L. Chang, Z. Chen, L. J. Lee, Application of DODMA and Derivatives in Cationic Nanocarriers for Gene Delivery, Current Organic Chemistry, 2016, Vol20(17):1813-1819. DOI: 10.2174/1385272820666160202004348 T. Kuang, D. Fu, L. Chang, Z.Yang, J. Yang, P. Fan, M. Zhong, F. Chen, X. Peng, Enhanced Photocatalysis of Yittium-doped TiO2/D-PVA Composites: Degradation of Methyl Orange (MO) and PVCFilm. Science of Advanced Materials. 2016, Vol8(6): 1286-1292. DOI: 10.1166/sam.2016.2667 M. Li, B. Li, X. Zhang, Y. Song, L. Chang, Y. Chen, Investigation of the phase fluctuation effect on the BER performance of DPSK space downlink optical communication system onfluctuation channel, Optics Communications, 2016, 366,248-252. DOI: 10.1016/j.optcom.2016.01.003 L. Chang, M. Howdyshell, W. Liao, C. Chiang, D. Gallego-Perez, Z. Yang, J. Byrd, L. Wu, N. Muthusamy, L.J. Lee. R. Sooryakumar. Magnetic tweezer based 3D micro-electroporation system for high throughput transfection in living cells. Small. 2015, Vol11(15): 1818-1828. DOI: 10.1002/smll.201402564(ESI Highly cited paper) L. Chang, D. Gallego-Perez, X. Zhao, P. Bertani, Z. Yang, C. L. Chiang, V. Malkoc, C. K. Sen, L. Odonnell, J. Yu, W. Lu, L.J. Lee. Dielectrophoresis-assisted 3D Nanoelectroporation for Non-viral Cell Transfection in Adoptive Immunotherapy. Lab Chip. 2015, Vol15(15): 3147 – 3153. DOI: 10.1039/c5lc00553a(Annual HOT Article) Z. Yang#, L. Chang#, C. Chiang, L. J. Lee. Micro-/nano-electroporation for active gene delivery. Current Pharmaceutical Design, 2015, Vol21(42): 6081-6088. DOI: 10.2174/1381612821666151027152121 P. Bertani#, L. Chang#, D. Gallego-Perez, C. Chiang, R. Muthusamy, L. J. Lee, W. Lu, Boschetching for the creation of a 3D nano-electroporation system.Journal of Vacuum Science & Technology B. 2015. Vol33(6): 06F903. DOI: 10.1116/1.4932157 V. Malkoc, L. 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