Lythgoe, Katrina - University of Oxford

个人简介

I am a strong supporter of people who have had ‘alternative’ scientific career paths, and believe a good support network is vital: I returned to research with the help of a Wellcome Trust Career Re-Entry Fellowship, during which I worked part-time, and I was also awarded a L'Oreal UNESCO Fellowship for Women in Science. Before that, I was the Editor of Trends in Ecology & Evolution for seven years and had two children.

研究领域

I apply ecological and evolutionary theory to better predict the evolutionary dynamics of infectious disease in humans and other species, with the ultimate aim of informing public health decisions. In particular, I am interested in disentangling the, often conflicting, selection pressures acting on pathogens at different ecological levels, and to assess the impact this has on the evolutionary epidemiology of infectious disease. My approach is inter-disciplinary in nature, including the application and development of evolutionary theory, incorporating immunology into within-host models, using and making sense of next generation sequence data, and applying epidemiological theory. The current focus of my research is on HIV and hepatitis C virus, but the theory I develop has implications for our understanding of infectious disease more widely.

近期论文

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Lythgoe, K.A., F. Blanquart, L. Pellis, C. Fraser (2016) Large variations in HIV-1 viral load explained by shifting-mosaic metapopulation dynamics. PLoS Biology 14(10): e1002567 Fraser, C., K. Lythgoe*, G.E. Leventhal, G.Shirreff, T.D. Hollingsworth, S. Alizon, S. Bonhoeffer* (2014) Virulence and pathogenesis of HIV-1 infection: an evolutionary perspective. Science 343:124372 (*indicates equal contribution). Lythgoe, K.A.*, L.Pellis* & C. Fraser (2013) Is HIV short-sighted? Insights from a multi-strain nested model. Evolution 67:2769-82 (*indicates joint first authorship) Lythgoe, K.A. & C. Fraser (2012) New insights into the evolutionary rate of HIV-1 at the within- and between-host levels. Proc. Roy. Soc. B 279:3367-75 Lythgoe, K.A., L.J. Morrison, A.F. Read & J.D. Barry (2007) Parasite-intrinsic factors can explain ordered progression of trypanosome antigenic variation. Proc. Nat. Acad. Sci. USA 104:8095-8100 Lythgoe, K.A. (2000) The coevolution of parasites with host-acquired immunity and the evolution of sex. Evolution 54:1142-1156