Harding, Rosalind - University of Oxford

研究领域

My research investigates the evolution of genetic diversity in human and bacterial populations, with a current focus on bacterial species that have high profile clinical significance in the UK. I use an interdisciplinary approach that combines statistical population genetics, medical microbiology and biological anthropology, and I collaborate with researchers located in the Oxford Departments of Zoology and Statistics and at the John Radcliffe Hospital. We want to understand how antibiotic resistance and pathogenicity emerges from benign human commensal species, and how rapidly can newly evolving lineages attain a global reach across human host populations.

近期论文

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Bisharat N,Cohen DI, Maiden MC, Crook DW, Peto T, Harding RM (2007) The evolution of genetic structure in the marine pathogen, Vibrio vulnificus. Infection, Genetics and Evolution 7:685-693. Juhas M, Power P, Harding RM, Ferguson DJP, Dimopoulou ID, Elamin ARE, Mohd-Zain Z, Hood DW, Crook DW (2007) Sequence and functional analyses of Haemophilus spp. Genomic islands. Genome Biology. Full text Van Holst Pellekaan SM, Ingman M, Roberts-Thomson J, Harding RM. (2006) Mitochondrial genomics identifies major haplogroups in Aboriginal Australians. Am J Phys Anthrop 131(2):282-294 Fearnhead P, Harding RM, Schneider JA, Myers S and Donnelly P (2004) Application of coalescent methods to reveal fine scale rate variation and recombination hotspots. Genetics 167:2067-2081 Webster MT, Clegg JB, Harding RM (2003) Common 5’ Β-globin RFLP haplotypes harbor a surprising level of ancestral sequence mosaicism. Hum. Genet. 113:123-139