Gupta, Sunetra - University of Oxford

研究领域

My main area of interest is the evolution of diversity in pathogens, with particular reference to the infectious disease agents that are responsible for malaria, influenza and bacterial meningitis. I use simple mathematical models to generate new hypotheses regarding the processes that determine the population structure of these pathogens. I work closely with laboratory and field scientists both to develop these hypotheses and to test them.

近期论文

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Watkins ER, Penman BS, J, Buckee CO, Maiden MCJ & Gupta S (2015) Vaccination drives changes in metabolic and virulence profiles of Streptococcus pneumoniae. PLOS Pathogens 11:e1005034. doi:10.1371/journal.ppat.1005034 Wikramaratna PS, Lourenço J, Klenerman P, Pybus OG & Gupta S (2015) Effects of neutralising antibodies on escape from CD8+ T cell responses in HIV-1 infection. Phil. Trans. R. Soc. B 370:20140290. doi: 10.1098/rstb.2014.0290 Wikramaratna PS, Pybus OG & Gupta S (2014). Contact between bird species of different lifespans can promote the emergence of highly pathogenic avian influenza strains. Proc Natl Acad Sci 111:10767-72. doi: 10.1073/pnas.1401849111 Buckee CO, Recker M, Watkins ER & Gupta S (2011) Role of stochastic processes in maintaining discrete strain structure in antigenically diverse pathogen populations. Proc Natl Acad Sci 108:15504-9. doi: 10.1073/pnas.1102445108 Penman B, Pybus OG, Weatherall DJ & Gupta S (2009) Epistatic interactions between genetic disorders of hemoglobin can explain why the sickle cell gene is uncommon in the Mediterranean. Proc Natl Acad Sci 106: 21242-6 Recker, M., Pybus, O.G., Nee, S. & Gupta, S. (2007) The generation of influenza outbreaks by a network of host immune responses against a limited set of antigenic types. Proc Natl Acad Sci U S A. 104:7711-6.