Sharp, Trevor - University of Oxford - Department of Pharmacology

个人简介

Trevor Sharp graduated in Biochemistry at the University of Birmingham in 1979. He established his interest inneuropharmacology of CNS transmitters in the Department of Physiology and Pharmacology at the University of Nottingham where he obtained his PhD in 1983. He spent the next three years in the Department of Pharmacology at the Karolinska Institute, Stockholm with Urban Ungerstedt as a SERC and Karolinska Institute Overseas Fellow. In 1986 he joined the MRC Unit of Clinical Pharmacology in Oxford, and was appointed to the MRC External Scientific Staff in 1993. Following a further six years in the Department of Clinical Pharmacology, he joined the Department of Pharmacology at the start of the new millennium. Throughout his time in Oxford, Trevor Sharp’s research has focused on the pharmacology and physiology of monoamine transmitters, particularly in relation to the treatment and cause of psychiatric disorder. He holds visiting Professorships with the Universities of Maastricht and Hokkaido, and is currently a member of the executive committee of the Serotonin Club.

研究领域

Physiology and pharmacology of midbrain monoamine systems. • Neuropharmacology of antidepressants. • Neural mechanisms of mood and anxiety.

近期论文

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Bocchio, M, McHugh, SB, Bannerman, DM, Sharp, T, and Capogna, M (2016) Serotonin, Amygdala and Fear: Assembling the Puzzle. Bocchio, M, Fucsina, G, Oikonomidis, L, McHugh, SB, Bannerman, DM, Sharp, T, and Capogna, M (2015) Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala. Brouard, JT, Schweimer, JV, Houlton, R, Burnham, KE, Queree, P, and Sharp, T (2015) Pharmacological Evidence for 5-HT6 Receptor Modulation of 5-HT Neuron Firing in Vivo. McHugh, SB, Barkus, C, Lima, J, Glover, LR, Sharp, T, and Bannerman, DM (2015) SERT and uncertainty: serotonin transporter expression influences information processing biases for ambiguous aversive cues in mice. Schweimer, JV, Coullon, GSL, Betts, JF, Burnet, PWJ, Engle, SJ, Brandon, NJ, Harrison, PJ, and Sharp, T (2014) Increased burst-firing of ventral tegmental area dopaminergic neurons in D-amino acid oxidase knockout mice in vivo. Sharp, T (2013) Molecular and cellular mechanisms of antidepressant action. Le Masurier, M, Zetterstrom, T, Cowen, P, and Sharp, T (2013) Tyrosine-free amino acid mixtures reduce physiologically-evoked release of dopamine in a selective and activity-dependent manner. Singh, N, Halliday, AC, Thomas, JM, Kuznetsova, OV, Baldwin, R, Woon, ECY, Aley, PK, Antoniadou, I, Sharp, T, Vasudevan, SR, and Churchill, GC (2013) A safe lithium mimetic for bipolar disorder. Barkus, C, Line, SJ, Huber, A, Capitao, L, Lima, J, Jennings, K, Lowry, J, Sharp, T, Bannerman, DM, and McHugh, SB (2013) Variation in Serotonin Transporter Expression Modulates Fear-Evoked Hemodynamic Responses and Theta-Frequency Neuronal Oscillations in the Amygdala. Jennings, KA, Licht, CL, Bruce, A, Lesch, K, Knudsen, GM, and Sharp, T (2012) Genetic variation in 5-hydroxytryptamine transporter expression causes adaptive changes in 5-HT(4) receptor levels. Tan, SKH, Hartung, H, Sharp, T, and Temel, Y (2011) Serotonin-dependent depression in Parkinson's disease: a role for the subthalamic nucleus?