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个人简介

张灿阳,清华大学深圳国际研究生院助理教授、博士生导师、特别研究员。2014年博士毕业于华南理工大学化学工程专业(导师:章莉娟教授、钱宇教授),期间于德国慕尼黑大学联合培养(导师:Ernst Wagner院士),先后于华盛顿州立大学(合作导师:Zhenjia Wang教授)、麻省理工学院(新加坡科研中心,合作导师:Paula Hammond院士)从事博士后研究。主要从事功能生物医用材料设计与开发,靶向递送与控缓释技术研发,免疫调控,生物医用器件研发,面向肿瘤诊疗、抗菌抗感染、炎症免疫调控等应用的制剂工程研究等。迄今已发表学术论文40余篇,其中第一/通讯作者文章30余篇,包括Sci. Adv.、Adv. Mater.、Biomaterials、Bioact. Mater.、Chem. Eng. J.、J. Control. Release、Biomaterials、AIChE J.等国际高水平期刊,H-因子24。 教育经历 2009年09月-2014年12月,华南理工大学,化学工程专业,博士 2012年10月-2013年10月,慕尼黑大学,药学科技专业,联合培养 2005年09月-2009年06月,西南民族大学,化学工程与工艺专业,学士 工作经历 2021年5月-至今,清华大学深圳国际研究生院,助理教授 2019年06月-2020年12月,麻省理工学院-新加坡科研中心,博士后 2016年08月-2019年06月,华盛顿州立大学,博士后 2015年03月-2016年08月,国家纳米科学中心,助理研究员 学术兼职 Pharmaceutics、International Journal of Polymer Science杂志客座编辑;Journal of Future Foods编委 荣誉奖项 深圳市海外高层次人才,2021 山东省泰山学者,2020

研究领域

研究方向重点是面向生物医药与生命健康领域重大需求与问题,设计和开发多功能工程化生物材料载体和递送(剂型)策略,用于疾病诊断与治疗,如癌症、感染、自身免疫性疾病。主要有四个研究方向: 1) 刺激-响应型(聚β-氨基酯)材料库的设计(计算机辅助和模拟)与建立 2) 细胞介导的免疫调控靶向系统的开发 3) 基于产品工程与制剂工程的生物医药与健康工程研究 4) 微针相关技术与产品开发

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Yan Wang #, Juan Li#, Jinping Shi, Junyu Liu, Can Yang Zhang*, Graphene-based nanomaterials for cancer therapy and anti-infections, Bioactive Materials. 2022, 14, 335-349. Wen Xuan Li, Xiao Peng Zhang, Bo Zhi Chen, Wen Min Fei, Yong Cui*, Can Yang Zhang*, Xin Dong Guo*, An update on microneedle-based systems for diabetes, Drug Delivery and Translational Research. 2022, 1-12. Yun Hao Feng, Bo Zhi Chen, Wen Min Fei, Yong Cui, Can Yang Zhang*, Xin Dong Guo*, Mechanism studies on the cellular internalization of nanoparticles using computer simulations: A review, AIChE Journal, 2022, e17507. Jinping Shi#, Juan Li#, Yan Wang, Xiaobin Li, Can Yang Zhang*, TiO2-based Nanosystem for Cancer Therapy and Antimicrobial Treatment: A Review. Chemical Engineering Journal. 2021, 431, 133714. 黄龙;曾文;徐冰;张灿阳;马少华;张翀;王怡*;邢新会*, 口服多糖靶向药物递送体系在结肠疾病治疗中的应用研究进展, 药学学报, 2021, 1073. Yan Wang,Yuanjun Ma,Jinping Shi,Xianyu Yan,Jun Luo, Huilong Zhu, Kunpeng Jia*, Juan Li*,Can Yang Zhang*, Surface modification of monolayer MoS2 by baking for biomedical application, Frontiers in Chemistry, 2020, 8:741. Shuguang Zhang,Peiyao Zhu,Jiayuan He,Siyuan Dong,Peiwen Li,Can Yang Zhang*, Teng Ma*,TME-Responsive Polyprodrug Micelles for Multistage Delivery of Doxorubicin with Improved Cancer Therapeutic Efficacy in Rodents, Advanced Healthcare Materials, 2020, 9(18), 2000387. Jinping Shi, Juan Li*, Yan Wang, Jingjing Cheng, Can Yang Zhang*, Recent advances in MoS2-based photothermal therapy for cancer and infectious disease treatment, Journal of Materials Chemistry B, 2020, 8, 5793-5807. Can Yang Zhang, Xinyue Dong, Jin Gao, Wenjing Lin, Ze Liu, Zhenjia Wang*, Nanoparticle-induced neutrophil apoptosis increases survival in sepsis and alleviates neurological damage in stroke, Science Advances, 2019, 5(11), eaax7964. Can Yang Zhang, Wenjing Lin, Jin Gao, Xutong Shi, Maryam Davaritouchaee, Amy Nielsen, Rock Mancini, Zhenjia Wang*. pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury, ACS Applied Materials & Interfaces, 2019, 11(18), 16380-16390. Mengzhen Xu#, Can Yang Zhang#, Junguang Wu, Huige Zhou, Ru Bai, Ziyi Shen, Ying Liu*, and Jing Liu*, PEG-Detachable Polymeric Micelles Self-Assembled from Amphiphilic Copolymers for Tumor-Acidity-Triggered Drug Delivery and Controlled Release, ACS Applied Materials & Interfaces, 2019,11(6), 5701-5713. Xutong Shi, Can Yang Zhang*, Jin Gao, Zhenjia Wang*, Recent Advances in Photodynamic Therapy for Cancer and Infectious Diseases, Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology, 2019, e1560. Yongle Luo, Xujun Yin, Xi Yin, Anqi Chen, Lili Zhao, Gang Zhang, Wenbo Liao, Xiangxuan Huang*, Juan Li and Can Yang Zhang*, Dual pH/Redox-Responsive Mixed Polymeric Micelles for Anticancer Drug Delivery and Controlled Release, Pharmaceutics, 2019, 11(4), 176. Wen Yao Hu, Zhi Min Wu*, Qian Qian Yang, Yue Jin Liu, Juan Li, Can Yang Zhang*, Smart pH-responsive cationic polymeric micelles for programmed oral delivery of insulin, Colloids and Surfaces B: Biointerfaces, 2019, 183:110443-11-453. Zhimin Wu*, Manzhen Duan, Di Xiong, Can Yang Zhang*, Mesoscale Simulations of pH-Responsive Polymeric Micelles for Oral Drug Delivery, Pharmaceutics, 2019, 11, 620. Can Yang Zhang, Jin Gao, Zhenjia Wang*. Bioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management. Advanced Materials, 2018, 30(43), 1803618. Juan Li, Yuan Jun Ma, Yan Wang, Bo Zhi Chen, Xin Dong Guo*, Can Yang Zhang*. Dual redox/pH-responsive hybrid polymer-lipid composites: Synthesis, preparation, characterization and application in drug delivery with enhanced therapeutic efficacy. Chemical Engineering Journal, 2018, 341, 450-461. Qi Lei Wang, Jia Wei Ren, Bo Zhi Chen, Xuan Jin, Can Yang Zhang*, Xin Dong Guo*. Effect of humidity on mechanical properties of dissolving microneedles for transdermal drug delivery. Journal of Industrial and Engineering Chemistry, 2018, 59, 251-258. Xiangxuan Huang, Wenbo Liao, Zhihao Xie, Deshi Chen, Can Yang Zhang*. A pH-responsive prodrug delivery system self-assembled from acid-labile doxorubicin-conjugated amphiphilic pH-sensitive block copolymers. Materials Science & Engineering C-Materials for Biological Applications. 2018, 90, 27-37. Can Yang Zhang, Shiyuan Peng, Bin Zhao, Wenji Luo, Lijuan Zhang*. Polymeric micelles self-assembled from amphiphilic polymers with twin disulfides used as siRNA carriers to enhance the transfection. Materials Science & Engineering C-Materials for Biological Applications, 2017, 546-552. Can Yang Zhang, Quan Chen, Wen Sheng Wu, Xin Dong Guo, Cheng Zhi Cai, Li Juan Zhang*. Synthesis and evaluation of cholesterol-grafted PEGylated peptides with pH-triggered property as novel drug carriers for cancer chemotherapy. Colloids and Surfaces B: Biointerfaces, 2016, 11 (142): 55-64. Can Yang Zhang, Petra Kos, Katharina Müller, Waldemar Schrimpf, Christina Troiber, Ulrich L?chelt, Claudia Scholz, Don C. Lamb, Ernst Wagner*. Native chemical ligation for conversion of sequence-defined oligomers into targeted pDNA and siRNA carriers. Journal of Controlled Release, 2014, 180, 42-50. Can Yang Zhang, You Qiang Yang, Tu Xiong Huang, Bin Zhao, Xin Dong Guo, Ju Fang Wang, Li Juan Zhang*. Self-assembled pH-responsive MPEG-b-(PLA-co-PAE) block copolymer micelles for anticancer drug delivery. Biomaterials, 2012, 33, 6273-6283.

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