王润铭 - 清华大学 - 深圳国际研究生院

个人简介

教育经历 2014年01月-2018年02月，香港大学，生物无机化学专业，博士（导师：孙红哲教授，高一村副教授） 2012年09月-2013年12月，武汉工程大学，分析化学，其他（导师：陈嵘教授） 2008年09月-2012年07月，武汉工程大学，食品科学与工程专业，学士工作经历 2022年02月-至今，清华大学深圳国际研究生院，助理教授 2018年10月-2021年10月，香港大学，博士后 2018年4月-2018年9月，香港大学，研究助理学术兼职 Infectious Diseases Reviews 杂志编辑委员会委员 Frontiers in Environmental Chemistry 杂志客座编辑 Frontiers in Chemistry 杂志客座编辑荣誉奖项 2022年《麻省理工科技评论》“35岁以下科技创新35人” 亚太区, 麻省理工科技评论（MIT Technology Review） 2022年国家海外高层次人才（青年）项目 2022年“鹏城孔雀计划”特聘岗位B类人才 2021年香港十大创科新闻 2021年 Faculty Knowledge Exchange (KE) Award (Team)，The University of Hong Kong 2021年 Global Young Scientists Summit 2021，Singapore（virtual meeting） 2021年 1st HKU-Pasteur Research Pole Fellowship, Hong Kong， (declined) 2018年 Best Oral Presentation Award，9th Asian Biological Inorganic Chemistry Conference, Singapore 2016年 Royal Society of Chemistry Books Awards of 8th Asian Biological, Auckland, New Zealand 2015年 Outstanding Teaching Assistant, The University of Hong Kong, Hong Kong

研究领域

王润铭博士长期从事生物无机化学、生物学和微生物学等交叉科学领域的研究。王润铭课题组的研究重点主要落脚于金属组相关的化学生物学、系统生物学、与合成生物学。前期通过研发创新药物及相关的（纳米）化学/生物学工具，对病原细菌、病毒和真核细胞中关键金属蛋白（酶）的结构和功能进行调控，在攻克新发传染性疾病（抗菌素耐药菌感染和COVID-19）、恶性肿瘤及衰老等重大科学问题的研究中取得一定的成绩。主要研究方向：（1）无机系统生物学的研究。旨在发展高通量组学技术和生物信息分析技术，揭示新发传染性疾病和重大慢病中与金属组相关的网络调控、表观遗传等分子机制（2）AI驱动金属蛋白质理性从头设计、结构预测及计算病理学研究（3）金属生物大分子的合成生物学研究。聚焦金属蛋白质/多肽的合成生物学元器件、分子线路和生命系统的设计、构建与优化，实现功能性食品与药品的高效的生物制造（4）小分子治疗药物与疫苗（及佐剂）的创制。以生物体内关键的金属蛋白质为直接作用靶点，或非必需元素干预细胞生命过程的方式，设计与合成新药，并完成药理及药剂研究

近期论文

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Metallo-sideromycin as a dual functional complex for combating antimicrobial resistance Gut lumen-targeted oral delivery system for bioactive agents to regulate gut microbiome Current and Perspective Sensing Methods for Monkeypox Virus Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver Orally administered bismuth drug together with N-acetyl cysteine as a broad-spectrum anti-coronavirus cocktail therapy Clofazimine broadly inhibits coronaviruses including SARS-CoV-2 Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms Deciphering molecular mechanism of silver by integrated omic approaches enables enhancing its antimicrobial efficacy in E. coli Combination of gallium(III) with acetate for combating antibiotic resistant Pseudomonas aeruginosa A Novel Synthetic Compound, Bismuth Zinc Citrate, Could Potentially Reduce Cisplatin-Induced Toxicity Without Compromising the Anticancer Effect Through Enhanced Expression of Antioxidant Protein Systems Approaches for Unveiling the Mechanism of Action of Bismuth Drugs: New Medicinal Applications beyond Helicobacter Pylori Infection Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials Identification of Catabolite Control Protein A from Staphylococcus aureus as a Target of Silver Ions Ionic liquid-employed synthesis of Bi 2 E 3 (E = S, Se, and Te) hierarchitectures: The case of Bi 2 S 3 with superior visible-light-driven Cr(VI) photoreduction capacity Size-tunable fabrication of multifunctional Bi2O3 porous nanospheres for photocatalysis, bacteria inactivation and template-synthesis A Review on Bismuth-Related Nanomaterials for Photocatalysis Highly efficient photocatalytic reduction of Cr(VI) by bismuth hollow nanospheres BiOX (X = Cl, Br, I) nanostructures: Mannitol-mediated microwave synthesis, visible light photocatalytic performance, and Cr(VI) removal capacity Controllable microwave and ultrasonic wave combined synthesis of ZnO micro-/nanostructures in HEPES solution and their shape-dependent photocatalytic activities Solvothermal Synthesis of Layered BiOCl Nanosheets and Their Efficient VisibleLight-Induced Photocatalytic Activities Tunable BiOCl hierarchical nanostructures for high-efficient photocatalysis under visible light irradiation Template-Free Fabrication of Bi 2 O 3 and (BiO) 2 CO 3 Nanotubes and Their Application in Water Treatment One-pot solvothermal synthesis of Pd/Fe3O4 nanocomposite and its magnetically recyclable and efficient catalysis for Suzuki reactions