个人简介
教育经历
March, 2014, Ph.D. in Pharmaceutical Sciences, Tohoku University, Japan, Advisor: Dr. Toshifumi Inada
Thesis title: Analysis of molecular mechanism of No-Go Decay and Dom34:Hbs1 targeting mRNA
March, 2011,Master of Science, Nagoya University, Japan;
Thesis title: Analysis of translational regulator Pab1p on non-translating mRNA
March, 2009, Bachelor of Science, Nagoya University, Japan
工作经历
September, 2021– present, Assistant Professor, Tsinghua Shenzhen International Graduate School, China
April, 2020–August, 2021, Assistant Project Scientist with Dr. Brian Zid, University of California San Diego
December, 2016–March, 2020, Postdoctoral Scholar with Dr. Brian Zid, University of California San Diego
April, 2016–May, 2016, Visiting researcher with Dr. Robert Singer, Albert Einstein School of Medicine
March, 2014–November, 2016, Postdoctoral Scholar with Dr. Susanne Rafelski (currently at Allen Institute for Cell Science), University of California Irvine
荣誉奖项
April, 2018 – March, 2021, Research Fellowship for Young Scientists (PD), Japan Society for the Promotion of Science (JSPS)
December, 2016 – November, 2017, Research Fellowship for Research Abroad, The Uehara Memorial Foundation
April, 2014 – March, 2016, Postdoctoral Fellowship for Research Abroad, Japan Society for the Promotion of Science (JSPS)
April, 2011 – March, 2014, Research Fellowship for Young Scientists (DC1), Japan Society for the Promotion of Science (JSPS)
September, 2019, 2019 National Postdoc Appreciation Week Nominee, University of California San Diego
December, 2015, 2015 Education Committee Travel Awards, American Society of Cell Biology 2015
November, 2013, 2014 Grant for Study Abroad, Mochida Memorial Foundation for Medical and Pharmaceutical Research
September, 2012, Poster Award (2012), EMBO | EMBL 2012 Symposia Quality Control – From Molecules to Organelles
September, 2010, Yeast genetics forum poster prize, The 43rd study meeting: Yeast Genetics Society of Japan
March, 2009, Graduate presentation award, Nagoya University Department of Science Division of Biological Science
研究领域
通过线粒体3D空间结构解码基因调控的原理机制
线粒体是参与ATP生产的关键细胞器，生物化学反应的枢纽，并调节细胞活动例如细胞老化，癌症和应激。线粒体也是一种非常动态的结构，随着细胞和环境的改变而发生形态的变化。尽管已有许多线粒体反应路径和形态改变的研究，但这些形态变化与基因表达调控之间的联系仍需深入探究。细胞衰老、癌症和应激期间线粒体形态的变化如何影响基因调控？线粒体是如何调节mRNA定位和控制翻译从而应对细胞的代谢需求？
近期论文
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Tsuboi T*, Viana MP, Xu F, Yu J, Chanchani R, Arceo XG, Tutucci E, Choi J, Chen YS, Singer RH, Rafelski SM*, Zid BM*. Mitochondrial volume fraction and translation duration impact mitochondrial mRNA localization and protein synthesis. (2020) Elife, 9, e57814. [*co-correspondence authors]
Tsuboi T*, Leff J, Zid BM*. Post-transcriptional control of mitochondrial protein composition in changing environmental conditions. (2020) Biochem Soc Trans. BST20200250. [*co-correspondence authors] Review
Tsuboi T, Yamazaki R, Nobuta R, Ikeuchi K, Makino S, Ohtaki A, Suzuki Y, Yoshihisa T, Trotta C, Inada T. The tRNA Splicing Endonuclease Complex Cleaves the Mitochondria-localized CBP1 mRNA. (2015) The Journal of Biological Chemistry, 290(26), 16021-16030.
Izawa T, Tsuboi T, Kuroha K, Inada T, Nishikawa S, Endo T. Roles of dom34:hbs1 in nonstop protein clearance from translocators for normal organelle protein influx. (2012) Cell Reports, 2(3), 447-453
Tsuboi T, Kuroha K, Kudo K, Makino S, Inoue E, Kashima I, Inada T. Dom34:hbs1 plays a general role in quality-control systems by dissociation of a stalled ribosome at the 3' end of aberrant mRNA. (2012) Molecular Cell, 46(4), 518-529.
Tsuboi T, Inada T. Tethering of poly(A)-binding protein interferes with non-translated mRNA decay from the 5' end in yeast. (2010) The Journal of Biological Chemistry, 285(44), 33589-33601.
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