Jefferys, John - University of Oxford - Department of Pharmacology

个人简介

Professor Jefferys was educated in the Department of Physiology at University College London, where he received his BSc and PhD, which was on dendritic action potentials and neuronal sensitivity to electric fields. His first postdoctoral post was with P. K. Thomas and John Newsom-Davis at the Royal Free Hospital (Department of Neurology) on peripheral neuropathies. He moved to the Sobell Department of Neurophysiology at the Institute of Neurology, Queen Square, London, which was led by Prof Tom Sears, who encouraged him to develop his work on the hippocampus and on chronic models of epilepsy. He was awarded a Wellcome Senior Lecturship in Physiology and Biophysics in Imperial College of Science Technology and Medicine at St Mary’s Medical School (which was led by Prof Charles Michel), where he developed his work on the pathophysiology of chronic epilepsy and prion diseases, and also on the physiology of cortical “gamma” oscillations. His first tenured faculty position was as Professor of Neuroscience at the University of Birmingham, initially in the Department of Physiology (led by Prof John Coote), then the Division of Neuroscience (including 4 years as Head of Division) and finally in the School of Clinical and Experimental Medicine. During his time in Birmingham he was elected to the Academy of Medical Sciences. His recent move to Oxford is primarily to promote translational research in epilepsy.

研究领域

Professor Jefferys’ expertise is in the cellular physiology of neurons of the hippocampus and cortex, their organisation into functional networks, and especially how they can malfunction in chronic epilepsy. His research has led to insights into: network mechanisms of acute seizures and chronic epileptic foci, (patho)physiology of prion protein and prion diseases, network mechanisms of cortical oscillations, and sensitivities of brain tissue to electric fields. His group currently is working on how repeated epileptic seizures can impact on the functioning of the heart and other bodily systems that may provide explanations for the low, but real, risk of sudden death in epilepsy (SUDEP). Finding out mechanisms that could cause SUDEP is an important step towards predicting and preventing this lethal event

近期论文

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Rombo, DM, Newton, K, Nissen, W, Badurek, S, Horn, JM, Minichiello, L, Jefferys, JGR, Sebastiao, AM, and Lamsa, KP (2014) Synaptic mechanisms of adenosine A receptor-mediated hyperexcitability in the hippocampus. Jefferys, JGR (2014) How does epileptic activity spread? Jefferys, JGR (2014) Do seizures in the pilocarpine model start in the hippocampal formation? Janca, R, Jezdik, P, Cmejla, R, Tomasek, M, Worrell, GA, Stead, M, Wagenaar, J, Jefferys, JGR, Krsek, P, Komarek, V, Jiruska, P, and Marusic, P (2014) Detection of Interictal Epileptiform Discharges Using Signal Envelope Distribution Modelling: Application to Epileptic and Non-Epileptic Intracranial Recordings.