个人简介

Dr. Tommas Ellender completed his D.Phil. in Integrative Physiology at the University of Oxford in 2009 under the supervision of Professor Ole Paulsen. He was then recruited as a postdoctoral fellow to work with Professor Paul Bolam in Oxford studying the complex circuitry of the basal ganglia. In 2010, Tommas was elected as a Biomedical Junior Research Fellow at Linacre College, Oxford. In 2012, he moved to the Department of Pharmacology to undertake postdoctoral work with Colin Akerman, where his research focused on the developmental processes underlying the construction of neural circuits. He concurrently held a Research Associate position at Corpus Christi College, Oxford. In 2015, Tommas was awarded a MRC Career Development Award, enabling him to pursue an independent research programme at the Department of Pharmacology.

研究领域

Development of the striatal neural circuitry. Neuromodulation of striatal circuit function. Cellular mechanisms underlying the generation of physiological and pathological neural network activity

Our current research efforts are focused on defining the early developmental processes controlling the formation of the striatum, with the aim of generating rationale and identifying targets for intervention in a range of neurodevelopmental disorders involving the basal ganglia.

近期论文

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Bocchio, M, Fisher, SP, Unal, G, Ellender, TJ, Vyazovskiy, VV, and Capogna, M (2016) Sleep and Serotonin Modulate Paracapsular Nitric Oxide Synthase Expressing Neurons of the Amygdala. Bolam, JP and Ellender, TJ (2015) Histamine and the striatum. Ellender, TJ, Raimondo, JV, Irkle, A, Lamsa, KP, and Akerman, CJ (2014) Excitatory effects of parvalbumin-expressing interneurons maintain hippocampal epileptiform activity via synchronous afterdischarges. Smith, Y, Galvan, A, Ellender, TJ, Doig, N, Villalba, RM, Huerta-Ocampo, I, Wichmann, T, and Bolam, JP (2014) The thalamostriatal system in normal and diseased states. Ellender, TJ, Harwood, J, Kosillo, P, Capogna, M, and Bolam, JP (2013) Heterogeneous properties of central lateral and parafascicular thalamic synapses in the striatum. Raimondo, JV, Kay, L, Ellender, TJ, and Akerman, CJ (2012) Optogenetic silencing strategies differ in their effects on inhibitory synaptic transmission. Ellender, TJ, Huerta-Ocampo, I, Deisseroth, K, Capogna, M, and Bolam, JP (2011) Differential modulation of excitatory and inhibitory striatal synaptic transmission by histamine. Ellender, TJ and Paulsen, O (2010) The many tunes of perisomatic targeting interneurons in the hippocampal network.