罗赛 - 清华大学

个人简介

罗赛博士2011年获得厦门大学生物学学士学位，2016年取得清华大学生物学博士学位，随后加入哈佛大学医学院和波士顿儿童医院进行博士后研究，2023年全职任教于清华大学，现为清华大学医学院助理教授。

研究领域

病毒疫苗和广谱中和抗体的研究；B细胞受体多样化和等位基因排除的机制研究。目前的研究兴趣包括通过人源化小鼠模型探究病毒感染过程中引发的免疫反应，研究和重塑高突变RNA病毒的广谱中和抗体的产生过程，从而开发新型疫苗和治疗性抗体。同时，进一步研究B细胞受体在发育过程中多样化的产生机制以及可能由非编码RNA介导的等位基因排除的分子机制。获奖信息 2021年第九届Norman L. Letvin青年学者奖 2016年吴瑞奖学金

近期论文

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S. Luo*?, J. Zhang?, A. J. B. Kreutzberger?, A. Eaton, R. J. Edwards, C. Jing, H. Q. Dai, G. D. Sempowski, K. Cronin, R. Parks, A. Y. Ye, K. Mansouri, M. Barr, N. Pishesha, A. C. Williams, L. Vieira Francisco, A. Saminathan, H. Peng, H. Batra, L. Bellusci, S. Khurana, S. M. Alam, D. C. Montefiori, K. O. Saunders, M. Tian, H. Ploegh, T. Kirchhausen*, B. Chen*, B. F. Haynes*, F. W. Alt*, An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusion. Sci Immunol 7, eadd5446 (2022). (*co-corresponding author) (?co-first author) S. Luo?, C. Jing?, A. Y. Ye?, S. Kratochvil, C. A. Cottrell, J. Koo, A. C. Williams, L. V. Francisco, H. Batra, E. Lamperti, O. Kalyuzhniy, Y. Zhang, A. Barbieri, J. P. Manis, B. F. Haynes, W. R. Schief, F. D. Batista, M. Tian, F. W. Alt, Humanized V(D)J-rearranging and TdT-expressing Mouse Vaccine Models with Physiological HIV-1 Broadly Neutralizing Antibody Precursors. Proc Natl Acad Sci, U S A 120, e2217883120 (2023) (?co-first author) X. Han, J. Zhang, Y. Liu, X. Fan, S. Ai, Y. Luo, X. Li, H. Jin, S. Luo, H. Zheng, Y. Yue, Z. Chang, Z. Yang, F. Tang, A. He, X. Shen, The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2. Development 146, (2019). X. Han?, S. Luo?, G. Peng, J. Y. Lu, G. Cui, L. Liu, P. Yan, Y. Yin, W. Liu, R. Wang, J. Zhang, S. Ai, Z. Chang, J. Na, A. He, N. Jing, X. Shen, Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development. J Mol Cell Biol 10, 175-178 (2018). (?co-first author) S. Luo, J. Y. Lu, L. Liu, Y. Yin, C. Chen, X. Han, B. Wu, R. Xu, W. Liu, P. Yan, W. Shao, Z. Lu, H. Li, J. Na, F. Tang, J. Wang, Y. E. Zhang, X. Shen, Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells. Cell Stem Cell 18, 637-652 (2016). N. Mi, Y. Chen, S. Wang, M. Chen, M. Zhao, G. Yang, M. Ma, Q. Su, S. Luo, J. Shi, J. Xu, Q. Guo, N. Gao, Y. Sun, Z. Chen, L. Yu, CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane. Nat Cell Biol 17, 1112-1123 (2015)