姜云耀 - 清华大学

个人简介

姜云耀博士于2010年获延边大学农学学士学位，2015年获韩国江原大学医学生命工程博士学位。曾在中国中医科学院西苑医院开展中药药理学博士后研究工作。先后在Carbohydrate Polymers、Bioinorganic Chemistry and Applications和International Journal of Molecular Sciences等领域内高水平期刊以第一作者身份发表研究论文20余篇，在国际学术会议中发表数十篇研究成果。曾获得韩国Nutraceutical Bio BK21优秀青年学者奖学金，获得2020年度中国商业联合会科学技术奖一等奖及2021年产学研合作创新成果奖优秀奖。先后主持及参与国家重点基础研究发展计划（973计划）、国家重大研发计划匹配项目、国家自然科学基金项目、中国博士后科学基金项目及韩国农林部项目等。在中药及其复方物质基础和作用机制研究中具有丰富的经验和较高的科研水平。科研经历姜云耀博士在攻读硕士及博士学位期间主要从事天然产物的研究工作，主要针对具有药用价值的植物开展提取、分离、活性评价和作用机制等相关研究。先后对中药木贼、刺五加、山牛蒡、当归和细辛进行了相关研究。2016年回国后进入中国中医科学院国家中医药管理局和北京市中药药理重点实验室从事中药药理方向博士后研究工作。在此期间，主要参与973计划“基于病证结合的气血相关理论研究”项目的科研工作，并入选“中国中医科学院博士后培优计划”。2019年加入清华大学药学院中药研究院开展研究工作，主要负责了中药材黄芩和淫羊藿国际标准的研究和申报工作，作为项目负责人开展了中药材黄芪、麦冬的药学研究和植物代谢组学数据库研究，并独立开展了益气通络颗粒治疗脑梗死的物质基础和作用机制研究，以及中医“气”的生物学基础研究和中药人参、黄芪补气功效的生物学基础研究等工作。学术兼职世界中医药学会联合会血液病专业委员会理事中国中药协会中药产品开发与培育专业委员会委员中国生物工程学会生物科学支撑技术专业委员会专家委员 Frontiers in Pharmacology，Topic Editor and Review Editor Frontiers in Immunology，Review Editor Frontiers in Nutrition，Review Editor Frontiers in Chemistry，Review Editor 荣誉和奖励产学研合作创新成果奖优秀奖，2021 中国商业联合会科学技术奖一等奖，2020 中国中医科学院博士后培优计划，2018 韩国Nutraceutical Bio BK21优秀青年学者，2015 韩国Nutraceutical Bio BK21 奖学金，2010—2013

研究领域

中药物质基础和作用机制，以及中药功效的生物学基础研究。中药是一个极其复杂的体系，具有多组分、多靶点、多作用途径的特点，其发挥作用的药效物质基础不清楚，作用机制不明确，极大地限制了中药的应用和国际化进程。利用系统生物学和组学等现代生命科学的研究方法和技术，结合传统中医药研究理论，建立全面阐述中药物质基础和作用机制的研究思路和方法，阐明中药作用机理。中药功效是在传统中医理论的基础上对中药临床作用的系统总结，是多种特定化学成分在特定病理条件下对机体进行整体调节作用的生物学效应，代表了中药的整体效应。对中药的功效研究更符合传统的中医药理论，更有利于以中医理论为指导的临床应用和评价。用现代生命科学的方法和语言对中药的功效进行表征和解释。

近期论文

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Han L., Yuan Y., Chen X., Huang J., Wang G., Zhou C., Dong J., Zhang N., Zhang Y., Yin H., Jiang Y.* A candidate drug screen strategy: the discovery of oroxylin A in Scutellariae Radix against aepsis via the correlation analysis between plant metabolomics and pharmacodynamics. Frontiers in Pharmacology. 2022, 13:861105. 张雅娟, 姜云耀*. “十四五”时期中医药现代化主要研究方向的探讨. 世界科学技术-中医药现代. 2022, 24:1309-1314. 俞磊明, 张娜, 李琦, 朱光明, 黄维, 王卫华, 姜云耀*. UPLC-MS/MS 法快速测定多效唑在麦冬中的残留及其对麦冬化学成分的影响. 中南药学. 2022, 20:1569-1578. Jiang Y.#, Luo Y.#, Chen X.#, Liu N., Hou J., Piao J., Song C., Si C.*, Hu W.*, Li X.* Senkyunolide H protects PC12 cells from OGD/R-induced injury via cAMP-PI3K/AKT signaling pathway. Journal of Ethnopharmacology. 2022, 282:114659. 张雅娟, 姜云耀*. 中药材质量的研究方法和进展. 中医药学报. 2021, 49:106-112. Zhang J.#, Jiang Y.#, Li Y., Li W., Zhou J., Chen J., Shang Z., Gu Q., Wang W., Shen T.*, Hu W.* Micelles modified with a chitosan-derived homing peptide for targeted intracellular delivery of ginsenoside compound K to liver cancer cells. Carbohydrate Polymers. 2020, 230:115576. Jiang Y., Piao J., Liu N., Hou J., Liu J.*, Hu W.* Effect of ultrafine powderization and solid dispersion formation via hot-melt extrusion on antioxidant, anti-Inflammatory, and the human Kv1.3 channel inhibitory activities of Angelica gigas Nakai. Bioinorganic Chemistry and Applications. 2020, 2020: 7846176. 姜云耀, 刘楠, 胡晓梅, 侯金才, 刘建勋*. 基于网络药理学方法探讨八珍汤治疗ITP 的作用机制. 世界科学技术-中医药现代. 2020, 22:1-8. 姜云耀*, 刘楠. 关于古代经典名方中“粗末”的考证. 世界科学技术-中医药现代. 2020, 22:1740-1744. Jiang Y.#, Liu N.#, Zhu S., Hu X.*, Chang D.*, Liu J.* Elucidation of the mechanisms and molecular targets of Yiqi Shexue Formula for treatment of primary immune thrombocytopenia based on network pharmacology. Frontiers in Pharmacology. 2019, 10:1136. Hu W.#, Jiang Y.#, Xue Q., Sun F., Zhang j., Zhou J., Niu Z., Li Q., Li F.*, Shen T.* Structural characterisation and immunomodulatory activity of a polysaccharide isolated from lotus (Nelumbo nucifera Gaertn.) root residues. Journal of Functional Foods. 2019, 2019:103457. Bai Y.#, Jiang Y.#, Liu T., Li F., Zhang J., Luo Y., Zhang L., Yan G., Feng Z., Li X.*, Wang X.*, Hu W.* Xinjiang herbal tea exerts immunomodulatory activity via TLR2/4-mediated MAPK signaling pathways in RAW264.7 cells and prevents cyclophosphamide-induced immunosuppression in mice. Journal of Ethnopharmacology. 2019, 228:179-187. Zhang J.#, Jiang Y.#, Liu N., Shen T., Jung H.W., Liu J.*, Yan B.C.* A network-based method for mechanistic investigation and neuroprotective effect on post-treatment of senkyunolid-H against cerebral ischemic stroke in mouse. Frontiers in Neurology. 2019, 10:1299. Luo Y. #, Li X. #, Liu T. #, Cao Y., Zhang J., Yaseen A., Sun F., Zheng W., Jiang Y.*, Si C.L.*, Hu W.* Senkyunolide H protects against MPP+-induced apoptosis via the ROS mediated mitogen-activated protein kinase pathway in PC12 cells. Environmental Toxicology and Pharmacology. 2019, 65:73-81. 姜云耀, 刘楠, 刘建勋*. 基于入脑成分的网络药理学方法探讨益气通络颗粒保护脑缺血再灌注损伤的作用机制. 中国药理学与毒理学杂志. 2019, 33:740. Zhang J.#, Wang Y.#, Jiang Y.#, Liu T., Luo Y., Diao E., Cao Y., Chen L., Zhang L., Gu Q., Zhou J., Sun F., Zheng W., Liu J.*, Li X.*, Hu W.* Enhanced cytotoxic and apoptotic potential in hepatic carcinoma cells of chitosan nanoparticles loaded with ginsenoside compound K. Carbohydrate Polymers. 2018, 198:537-545. Liu N.#, Jiang Y.#, Xing M., Zhao B., Hou J., Lim M., Huang J., Luo X., Han L.* Digital gene expression profiling analysis of aged mice under moxibustion treatment. Evidence-Based Complementary and Alternative. 2018, 2018: 4767328. 姜云耀, 孙明谦, 马博, 陈进成, 刘楠, 刘华, 刘建勋*. 组学技术在现代中药药理研究中的应用与思考. 世界科学技术-中医药现代. 2018, 20:1287-1295. Jiang Y., Liu N., Xue B., Hou J., Lin C., Ren J., Liu J.* Circulating microRNA profiles differ between hyperglycemia and euglycemia in coronary heart disease patients. BioMed Research International. 2017, 2017: 9192575. Li X.#, Shen J.#, Jiang Y.#, Shen T., You L., Sun X., Xu X., Hu W.*, Wu H.*, Wang G.* Anti-inflammatory effects of Chloranthalactone B in LPS-stimulated RAW264.7 cells. International Journal of Molecular Sciences. 2016, 17:1938. Jeong S.H.#, Jiang Y.#, Guo H., Wang M.H.*, Park J.B.* Anti-inflammatory and anticancer effects of methanol, ethanol and water extracts of Asiasarum heterotropoide. Biomedical Research. 2016, 27:103-109. Jiang Y., Yu L.*, Wang M.H.* N-trans-feruloyltyramine inhibits LPS-induced NO and PGE2 production in RAW 264.7 macrophages: involvement of AP-1 and MAP kinase signalling pathways. Chemico-Biological Interactions. 2015, 235:56-62. Jiang Y., Piao J., Cho H.J., Kang W.S.*, Kim H. Y.* Improvement in antiproliferative activity of Angelica gigas Nakai by solid dispersion formation via hot melting extrusion and induction of cell cycle arrest and apoptosis in HeLa cells. Bioscience, Biotechnology, and Biochemistry, 2015, 79:1635-1643. Jiang Y., Wang M.H.* Different solvent fractions of Acanthopanax senticosus Harms exert antioxidant and anti-Inflammatory activities and inhibit the human Kv1.3 channel. Journal of Medicinal Food. 2015, 18: 468-475. Guo H.#, Jiang Y.#, Wang M.H.* Synergistic anti-diabetic effect of Cirsium setidens combined with other plants in vitro and in vivo. Korean Journal of Plant Resources. 2015, 28:752-758. Jiang Y., Wang M.H.* Ethanol extract of Synurus deltoides (Aiton) Nakai suppresses in vitro LPS-induced cytokine production in RAW 264.7 macrophages and in vivo acute inflammatory symptoms. Nutrition Research and Practice. 2014, 8:11-19. Jiang Y., Hu W., Lee K.C., Wang M.H.* Antioxidant and anti-inflammatory activities of different solvent fractions from ethanol extract of Synurus deltoides (Aiton) Nakai leaves. Food Science and Biotechnology. 2013, 22:215-223. Jiang Y., Noh H., Wang M.H.* Comparison of biological activities of Synurus deltoides (Aiton) Nakai under different shading Cconditions. Korean Journal of Plant Resources. 2013, 26:686-694. Jiang Y., Hu W., Han W., Yeo J.H., Wang M.H.* Antioxidant and nitric oxide production inhibitory activities of scouring rush (Equisetum hyemale L.). Food Science and Biotechnology. 2012, 21:1037-1044. Jiang Y., Han W., Shen T., Wang M.H.* Antioxidant activity and protection from DNA damage by water extract from pine (Pinus densiflora) bark. Preventive Nutrition and Food Science. 2012, 17:116-121.