蒯锐 - 清华大学

个人简介

蒯锐博士于2008年和2011年在四川大学华西药学院获得学士和硕士学位。他于2017年博士毕业于美国密歇根大学药学院。博士期间他在James Moon和Anna Schwendeman教授的实验室从事药物制剂和免疫治疗的交叉研究。2018年初他加入了美国哈佛医学院教授Jeffrey Karp的实验室从事博士后研究工作。博士后期间的工作主要是通过仿生学及工程学的手段开发高效的药物递送系统。蒯锐博士已于本领域权威期刊如Nature Materials、Science Advances、Nature Communications、ACS Nano、 Biomaterials、Journal of Controlled Release等发表多篇论文。2020年9月蒯锐博士加入清华大学药学院开展独立研究。荣誉和奖励 2018 中国教育部留学基金委“优秀自费留学生” 2017 美国密歇根大学Norman Weiner 奖学金 2017 戈登会议(GRC)优秀海报奖 2017 美国药物科学家协会(AAPS)生物技术创新奖 2016 美国密歇根大学PSTP Annual Symposium海报奖 2015-2017 美国心脏协会 (AHA) 奖学金 2013 美国密歇根大学Broomfield 国际留学生奖 2013 四川省优秀硕士论文奖 2011 石药集团优秀学生奖

研究领域

多种新颖的免疫信号传导通路及相应调节药物的发现为通过调控免疫系统来治疗疾病带来了新的机遇，但是药物分子自身理化性质导致的不稳定性以及存在于组织、细胞、亚细胞层面的生理屏障严重妨碍了这些药物分子有效作用于靶点从而制约疗效。另一方面，非特异性的脱靶效应也会带来严重的毒副作用。本课题组将致力于在药物制剂和免疫治疗的交叉领域展开系列研究来克服上述挑战以便充分发挥免疫治疗的潜能。主要研究方向包括：（1）设计开发可克服药物不稳定性及有关生理屏障的制剂；（2）调节制剂在多尺度（如组织、细胞、亚细胞）的时空分布并研究其与免疫应答的相互关系；（3）探索制剂在不同疾病（如肿瘤、感染性疾病、自身免疫疾病）治疗中的应用并阐明其作用机制。

近期论文

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Levy O#, Kuai R#, Siren EM#, Bhere D, Milton Y, Nissar N, Biasia MD, Heinelt M, Reeve B, Abdi R, Alturki M, Fallatah M, Almalik A, Alhansan AH, Shah K, Karp JM. Shattering barriers towards clinically meaningful mesenchymal stromal cell (MSC) therapies. Science Advances, 2020; 6: eaba6884 Kuai R#, Singh PB#, Sun X#, Xu C, Najafabadi AH, Scheetz L, Yuan W, Xu Y, Hong H, Keskin DB, Wu CJ, Jain R, Schwendeman A, Moon JJ. Robust anti-tumor T cell response with efficient intratumoral infiltration by nanodisc cancer immunotherapy. Advanced Therapeutics, 2020, (In press) Kadiyala P, Li D, Nunez F, Altshuler D, Doherty R, Kuai R, Yu M, Kamran N, Edwards M, Moon JJ, Lowenstein P, Castro M, Schwendeman A. High density lipoprotein-mimicking nanodiscs for chemo-immunotherapy against glioblastoma multiforme. ACS Nano, 2019, 13, 2, 1365-1384. Kuai R#, Yuan W#, Son S, Nam J, Xu Y, Fan Y, Schwendeman A, Moon JJ. Elimination of established tumors with nanodisc-based combination chemoimmunotherapy. Science Advances, 2018; 4: eaao1736. Featured by ecancer, News Medical, ScienceNewsline, Newswise, Medical Press, EurekAlert. Kuai R#, Sun X#, Yuan W, Xu Y, Schwendeman A, Moon JJ. Subcutaneous nanodisc vaccination with neo-antigens for combination cancer immunotherapy. Bioconjugate Chemistry, 2018, 29 (3), 771-775. Nam J, Son S, Ochyl LJ, Kuai R, Schwendeman A and Moon JJ. Combination chemo-photothermal therapy elicits potent anti-tumor immunity and eliminates distal tumors. Nature Communications, 9, 1074 (2018). Ochyl LJ, Bazzill JD, Park C, Xu Y, Kuai R, Moon JJ. PEGylated tumor cell membrane vesicles as a new vaccine platform for cancer immunotherapy. Biomaterials, 2018, 182, 157-166. Park H#, Kuai R# , Jeon JE, Seo Y, Jung Y, Moon JJ, Schwendeman A, Cho S. Dual effective high-density lipoprotein-mimicking substance P nanodiscs for enhanced therapeutic angiogenesis in diabetic hindlimb ischemia. Biomaterials, 2018, 161, 69-80. Kuai R, Sun X, Yuan W, Ochyl LJ, Xu Y, Najafabadi AH, Scheetz L, Yu M, Balwani I, Schwendeman A, Moon JJ. Dual TLR agonist nanodiscs as a strong adjuvant system for vaccines and immunotherapy. Journal of Controlled Release, 2018, 282, 131-139. Kuai R#, Subramanian C#, White P#, Timmermann BN, Moon JJ, Cohen MS, Schwendeman A. Synthetic high density lipoprotein nanodiscs for targeted delivery to adrenocortical carcinoma. International Journal of Nanomedicine. 2017, 12, 6581-7594. Kuai R, Ochyl LJ, Bahjat KS, Schwendeman A, Moon JJ. Designer vaccine nanodiscs for personalized cancer immunotherapy. Nature Materials, 2017, 16 (4), 489-496. Featured by Nature World News, Science Daily, Fierce Biotech, Yahoo! News, R&D, eCancer, Medical Physics Web, Nanotechweb, Technology Networks, Technology.org, C2W.nl, La Stampa, Scientias, Controlled Environments, Tech Times, STRF.ru, Business Standard, CanIndia, La Razon, Health Canal, E! Informador, My Science, Azonano, Nanowerk, Health Medicine, The Medical News, Health Medicinet. Fan Y, Kuai R, Xu Y, Ochyl LJ, Irvine DJ, Moon JJ. Immunogenic cell death amplified by co-localized adjuvant delivery for cancer immunotherapy. Nano Letters, 2017, 17, 7387-7393. Kuai R, Li D, Chen YE, Moon JJ, Schwendeman A. High-density lipoproteins: nature’s multifunctional nanoparticles. ACS Nano, 2016, 10 (3), 3015–3041. Kuai R#, Yuan W#, Li W, Qin Y, Tang J, Yuan M, Fu L, Ran R, Zhang Z, He Q. Targeted delivery of cargoes into a murine solid tumor by a cell-penetrating peptide and cleavable poly(ethylene glycol) comodified liposomal delivery system via systemic administration. Molecular Pharmaceutics, 2011, 8 (6), 2151-2161. Kuai R#, Yuan W#, Qin Y, Chen H, Tang J, Yuan M, Zhang Z, He Q. Efficient delivery of payload into tumor cells in a controlled manner by TAT and thiolytic cleavable PEG co-modified liposomes. Molecular Pharmaceutics, 2010, 7(5), 1816-1826. 书的章节 Kuai R#, Ochyl LJ#, Schwendeman A, Moon JJ. (2016) Lipid-Based Nanoparticles for Vaccine Applications. In: Jo H., Jun HW., Shin J., Lee S. (eds) Biomedical Engineering: Frontier Research and Converging Technologies. Biosystems & Biorobotics, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-319-21813-7_8