Tsibouklis, John - The University of Portsmouth - School of Pharmacy and Biomedical Sciences

个人简介

Controlled and targeted drug delivery: design and development of specific retentive delivery systems aimed at mucosal surfaces; nanomaterials for the transport of chemotherapeutant; stimuli-responsive polymer conjugates for the release of therapeutic agents. Low-surface-energy materials: synthesis, surface characterisation of polymeric materials with ultra-low-surface-energy characteristics. Bioadhesion/mucoadhesion: bioadhesive materials for therapeutic use in the eye, mouth, stomach and colon. Biomolecular recognition: receptor molecules with potential applications as either binding agents or controlled release systems; support matrices for in vitro toxicology. Bioadhesion control: development of materials that inhibit bacterial binding to biological surfaces and biomaterials; use of responsive ('smart') polymers displaying hydrophilic-hydrophobic transitions. Therapeutic agents for targeting cancer tumours: boronated cages for cancer therapy; delivery vehicles for the transport of chemotherapeutants across the blood-brain barrier. Surface science research: the use of contact angle goniometry, atomic force microscopy, X-ray photoelectron spectroscopy, infrared spectroscopy and other techniques as means of quantifying surface heterogeneity.

研究领域

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Biomaterials with inherent resistance to bacterial colonisation, Bioadhesion/mucoadhesion, Surface Science Research, Colonic drug delivery, Ocular drug delivery, Boron neutron-capture therapy.