Schubert, Frank - The University of Portsmouth - School of Biological Sciences

个人简介

Inspired by the fascinating insight that biological research gives into the living world, I studied Biology in Germany at the Universities of Kiel and Heidelberg, graduating in 1989. I spent one year at the European Molecular Biology Laboratory, studying gene transfer methods with Dr Erwin Wagner (1988-1989), before starting my postgraduate studies at the Max-Planck-Institute of Biophysical Chemistry in Göttingen (1989-1994). During my PhD project in the group of Prof Peter Gruss I investigated the evolution of the Hox cluster in vertebrates and insects. My isolation and characterisation of a novel vertebrate homeobox gene expressed in the embryonic brain set the focus for my career – investigating the molecular mechanisms of brain development. Having obtained the doctorate from the University of Heidelberg, I joined the laboratory of Prof Andrew Lumsden at King's College London as an EMBO research fellow (1994-2003). My postdoctoral studies resulted in the isolation and characterisation of a number of developmental control genes, two successful PhD projects (Susan Chapman and Robin Gogoi), a collaboration with lab of Antonio Simeone, and a highly productive partnership with Susanne Dietrich whose work on paraxial mesoderm patterning is now a textbook-cited classic. Appointed to a faculty position at the University of Portsmouth in 2003, I am leading a lab working on vertebrate brain development. We focus on two main topics: neurone formation in the early brain, and brain vascularisation. During term the lab is buzzing with undergraduate project students joining the regular research team, while in the summer we often host 6th form students. A number of my former undergraduate students went on to careers in research, while several of the 6th form students have successfully applied for Oxbridge.

研究领域

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Gene regulatory networks controlling neurogenesis and cell fate in the early brain Axon guidance of early axon tracts in the embryonic brain Vascularisation of the embryonic brain Novel vector systems for gene expression in chick embryos